Numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism
Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyro...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1984 |
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| Umfang: |
2 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Fresenius' Zeitschrift für analytische Chemie - 1947, 317(1984) vom: Juni, Seite 712-713 |
| Übergeordnetes Werk: |
volume:317 ; year:1984 ; month:06 ; pages:712-713 ; extent:2 |
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NLEJ201749521 |
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| 245 | 1 | 0 | |a Numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism |
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| 520 | |a Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man. | ||
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| 700 | 1 | |a Wisser, H. |4 oth | |
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(DE-627)NLEJ201749521 DE-627 ger DE-627 rakwb eng Numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism 1984 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man. Springer Online Journal Archives 1860-2002 Ratge, D. oth Hansel, S. oth Wisser, H. oth in Fresenius' Zeitschrift für analytische Chemie 1947 317(1984) vom: Juni, Seite 712-713 (DE-627)NLEJ188989293 (DE-600)2235442-6 1618-2650 nnns volume:317 year:1984 month:06 pages:712-713 extent:2 http://dx.doi.org/10.1007/BF00593868 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 317 1984 6 712-713 2 |
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(DE-627)NLEJ201749521 DE-627 ger DE-627 rakwb eng Numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism 1984 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man. Springer Online Journal Archives 1860-2002 Ratge, D. oth Hansel, S. oth Wisser, H. oth in Fresenius' Zeitschrift für analytische Chemie 1947 317(1984) vom: Juni, Seite 712-713 (DE-627)NLEJ188989293 (DE-600)2235442-6 1618-2650 nnns volume:317 year:1984 month:06 pages:712-713 extent:2 http://dx.doi.org/10.1007/BF00593868 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 317 1984 6 712-713 2 |
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(DE-627)NLEJ201749521 DE-627 ger DE-627 rakwb eng Numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism 1984 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man. Springer Online Journal Archives 1860-2002 Ratge, D. oth Hansel, S. oth Wisser, H. oth in Fresenius' Zeitschrift für analytische Chemie 1947 317(1984) vom: Juni, Seite 712-713 (DE-627)NLEJ188989293 (DE-600)2235442-6 1618-2650 nnns volume:317 year:1984 month:06 pages:712-713 extent:2 http://dx.doi.org/10.1007/BF00593868 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 317 1984 6 712-713 2 |
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(DE-627)NLEJ201749521 DE-627 ger DE-627 rakwb eng Numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism 1984 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man. Springer Online Journal Archives 1860-2002 Ratge, D. oth Hansel, S. oth Wisser, H. oth in Fresenius' Zeitschrift für analytische Chemie 1947 317(1984) vom: Juni, Seite 712-713 (DE-627)NLEJ188989293 (DE-600)2235442-6 1618-2650 nnns volume:317 year:1984 month:06 pages:712-713 extent:2 http://dx.doi.org/10.1007/BF00593868 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 317 1984 6 712-713 2 |
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(DE-627)NLEJ201749521 DE-627 ger DE-627 rakwb eng Numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism 1984 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man. Springer Online Journal Archives 1860-2002 Ratge, D. oth Hansel, S. oth Wisser, H. oth in Fresenius' Zeitschrift für analytische Chemie 1947 317(1984) vom: Juni, Seite 712-713 (DE-627)NLEJ188989293 (DE-600)2235442-6 1618-2650 nnns volume:317 year:1984 month:06 pages:712-713 extent:2 http://dx.doi.org/10.1007/BF00593868 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 317 1984 6 712-713 2 |
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numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism |
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Numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism |
| abstract |
Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man. |
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Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man. |
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Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ201749521</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505193801.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1984 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ201749521</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Numbers ofα- andβ-adrenergic receptors in platelets and lymphocytes are altered in patients with hyper- and hypothyroidism</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1984</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">2</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Conclusions The assumption that receptors in human blood cells reflect the status of receptors outside the circulation is supported by similar receptor numbers in animal and human tissues [4,8]. The increase inβ-adrenergic receptors and the tendentiously higher activity of adenylate cyclase in thyrotoxic patients compared to euthyroid controls may represent a plausible mechanism for the reputed catecholamine supersensitivity in hyperthyroidism. Higher increases inβ-adrenergic receptor numbers induced by short-term administration of exogenous thyroid hormones compared to long-term endogenous overproduction of thyroid hormones may be due to adaption of human cells to thyroid hormone excess. As in animals [4] it is suggested that the balance ofα- andβ-adrenergic receptors in humans is dependent on the thyroid state. The decrease inβ-receptor numbers in the hypothyroid state may be associated with high catecholamine release in these patients. High variations in adrenergic receptor density suggest that adrenergic receptors are distinctly modulated in man.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ratge, D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hansel, S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wisser, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Fresenius' Zeitschrift für analytische Chemie</subfield><subfield code="d">1947</subfield><subfield code="g">317(1984) vom: Juni, Seite 712-713</subfield><subfield code="w">(DE-627)NLEJ188989293</subfield><subfield code="w">(DE-600)2235442-6</subfield><subfield code="x">1618-2650</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:317</subfield><subfield code="g">year:1984</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:712-713</subfield><subfield code="g">extent:2</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00593868</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">317</subfield><subfield code="j">1984</subfield><subfield code="c">6</subfield><subfield code="h">712-713</subfield><subfield code="g">2</subfield></datafield></record></collection>
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