Analysis of early fetal T-cell receptor δ chain in humans
Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain i...
Ausführliche Beschreibung
Autor*in: |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
1990 |
---|
Umfang: |
6 |
---|
Reproduktion: |
Springer Online Journal Archives 1860-2002 |
---|---|
Übergeordnetes Werk: |
in: Immunogenetics - 1974, 32(1990) vom: Mai, Seite 331-336 |
Übergeordnetes Werk: |
volume:32 ; year:1990 ; month:05 ; pages:331-336 ; extent:6 |
Links: |
---|
Katalog-ID: |
NLEJ202686132 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLEJ202686132 | ||
003 | DE-627 | ||
005 | 20210706105317.0 | ||
007 | cr uuu---uuuuu | ||
008 | 070528s1990 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)NLEJ202686132 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
245 | 1 | 0 | |a Analysis of early fetal T-cell receptor δ chain in humans |
264 | 1 | |c 1990 | |
300 | |a 6 | ||
336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
337 | |a nicht spezifiziert |b z |2 rdamedia | ||
338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
520 | |a Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment. | ||
533 | |f Springer Online Journal Archives 1860-2002 | ||
700 | 1 | |a Stoep, Nienke |4 oth | |
700 | 1 | |a Krijger, Ronald |4 oth | |
700 | 1 | |a Bruining, Jan |4 oth | |
700 | 1 | |a Koning, Frits |4 oth | |
700 | 1 | |a Elsen, Peter |4 oth | |
773 | 0 | 8 | |i in |t Immunogenetics |d 1974 |g 32(1990) vom: Mai, Seite 331-336 |w (DE-627)NLEJ188990437 |w (DE-600)1398344-1 |x 1432-1211 |7 nnns |
773 | 1 | 8 | |g volume:32 |g year:1990 |g month:05 |g pages:331-336 |g extent:6 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF00211647 |
912 | |a GBV_USEFLAG_U | ||
912 | |a ZDB-1-SOJ | ||
912 | |a GBV_NL_ARTICLE | ||
951 | |a AR | ||
952 | |d 32 |j 1990 |c 5 |h 331-336 |g 6 |
matchkey_str |
article:14321211:1990----::nlssfalftlclrcpo |
---|---|
hierarchy_sort_str |
1990 |
publishDate |
1990 |
allfields |
(DE-627)NLEJ202686132 DE-627 ger DE-627 rakwb eng Analysis of early fetal T-cell receptor δ chain in humans 1990 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment. Springer Online Journal Archives 1860-2002 Stoep, Nienke oth Krijger, Ronald oth Bruining, Jan oth Koning, Frits oth Elsen, Peter oth in Immunogenetics 1974 32(1990) vom: Mai, Seite 331-336 (DE-627)NLEJ188990437 (DE-600)1398344-1 1432-1211 nnns volume:32 year:1990 month:05 pages:331-336 extent:6 http://dx.doi.org/10.1007/BF00211647 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 32 1990 5 331-336 6 |
spelling |
(DE-627)NLEJ202686132 DE-627 ger DE-627 rakwb eng Analysis of early fetal T-cell receptor δ chain in humans 1990 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment. Springer Online Journal Archives 1860-2002 Stoep, Nienke oth Krijger, Ronald oth Bruining, Jan oth Koning, Frits oth Elsen, Peter oth in Immunogenetics 1974 32(1990) vom: Mai, Seite 331-336 (DE-627)NLEJ188990437 (DE-600)1398344-1 1432-1211 nnns volume:32 year:1990 month:05 pages:331-336 extent:6 http://dx.doi.org/10.1007/BF00211647 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 32 1990 5 331-336 6 |
allfields_unstemmed |
(DE-627)NLEJ202686132 DE-627 ger DE-627 rakwb eng Analysis of early fetal T-cell receptor δ chain in humans 1990 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment. Springer Online Journal Archives 1860-2002 Stoep, Nienke oth Krijger, Ronald oth Bruining, Jan oth Koning, Frits oth Elsen, Peter oth in Immunogenetics 1974 32(1990) vom: Mai, Seite 331-336 (DE-627)NLEJ188990437 (DE-600)1398344-1 1432-1211 nnns volume:32 year:1990 month:05 pages:331-336 extent:6 http://dx.doi.org/10.1007/BF00211647 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 32 1990 5 331-336 6 |
allfieldsGer |
(DE-627)NLEJ202686132 DE-627 ger DE-627 rakwb eng Analysis of early fetal T-cell receptor δ chain in humans 1990 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment. Springer Online Journal Archives 1860-2002 Stoep, Nienke oth Krijger, Ronald oth Bruining, Jan oth Koning, Frits oth Elsen, Peter oth in Immunogenetics 1974 32(1990) vom: Mai, Seite 331-336 (DE-627)NLEJ188990437 (DE-600)1398344-1 1432-1211 nnns volume:32 year:1990 month:05 pages:331-336 extent:6 http://dx.doi.org/10.1007/BF00211647 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 32 1990 5 331-336 6 |
allfieldsSound |
(DE-627)NLEJ202686132 DE-627 ger DE-627 rakwb eng Analysis of early fetal T-cell receptor δ chain in humans 1990 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment. Springer Online Journal Archives 1860-2002 Stoep, Nienke oth Krijger, Ronald oth Bruining, Jan oth Koning, Frits oth Elsen, Peter oth in Immunogenetics 1974 32(1990) vom: Mai, Seite 331-336 (DE-627)NLEJ188990437 (DE-600)1398344-1 1432-1211 nnns volume:32 year:1990 month:05 pages:331-336 extent:6 http://dx.doi.org/10.1007/BF00211647 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 32 1990 5 331-336 6 |
language |
English |
source |
in Immunogenetics 32(1990) vom: Mai, Seite 331-336 volume:32 year:1990 month:05 pages:331-336 extent:6 |
sourceStr |
in Immunogenetics 32(1990) vom: Mai, Seite 331-336 volume:32 year:1990 month:05 pages:331-336 extent:6 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
isfreeaccess_bool |
false |
container_title |
Immunogenetics |
authorswithroles_txt_mv |
Stoep, Nienke @@oth@@ Krijger, Ronald @@oth@@ Bruining, Jan @@oth@@ Koning, Frits @@oth@@ Elsen, Peter @@oth@@ |
publishDateDaySort_date |
1990-05-01T00:00:00Z |
hierarchy_top_id |
NLEJ188990437 |
id |
NLEJ202686132 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ202686132</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706105317.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1990 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ202686132</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Analysis of early fetal T-cell receptor δ chain in humans</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1990</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Stoep, Nienke</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Krijger, Ronald</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bruining, Jan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Koning, Frits</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Elsen, Peter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Immunogenetics</subfield><subfield code="d">1974</subfield><subfield code="g">32(1990) vom: Mai, Seite 331-336</subfield><subfield code="w">(DE-627)NLEJ188990437</subfield><subfield code="w">(DE-600)1398344-1</subfield><subfield code="x">1432-1211</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:32</subfield><subfield code="g">year:1990</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:331-336</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00211647</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">32</subfield><subfield code="j">1990</subfield><subfield code="c">5</subfield><subfield code="h">331-336</subfield><subfield code="g">6</subfield></datafield></record></collection>
|
series2 |
Springer Online Journal Archives 1860-2002 |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188990437 |
format |
electronic Article |
delete_txt_mv |
keep |
collection |
NL |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
1432-1211 |
topic_title |
Analysis of early fetal T-cell receptor δ chain in humans |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
zu |
author2_variant |
n s ns r k rk j b jb f k fk p e pe |
hierarchy_parent_title |
Immunogenetics |
hierarchy_parent_id |
NLEJ188990437 |
hierarchy_top_title |
Immunogenetics |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)NLEJ188990437 (DE-600)1398344-1 |
title |
Analysis of early fetal T-cell receptor δ chain in humans |
spellingShingle |
Analysis of early fetal T-cell receptor δ chain in humans |
ctrlnum |
(DE-627)NLEJ202686132 |
title_full |
Analysis of early fetal T-cell receptor δ chain in humans |
journal |
Immunogenetics |
journalStr |
Immunogenetics |
lang_code |
eng |
isOA_bool |
false |
recordtype |
marc |
publishDateSort |
1990 |
contenttype_str_mv |
zzz |
container_start_page |
331 |
container_volume |
32 |
physical |
6 |
format_se |
Elektronische Aufsätze |
title_sort |
analysis of early fetal t-cell receptor δ chain in humans |
title_auth |
Analysis of early fetal T-cell receptor δ chain in humans |
abstract |
Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment. |
abstractGer |
Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment. |
abstract_unstemmed |
Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment. |
collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
title_short |
Analysis of early fetal T-cell receptor δ chain in humans |
url |
http://dx.doi.org/10.1007/BF00211647 |
remote_bool |
true |
author2 |
Stoep, Nienke Krijger, Ronald Bruining, Jan Koning, Frits Elsen, Peter |
author2Str |
Stoep, Nienke Krijger, Ronald Bruining, Jan Koning, Frits Elsen, Peter |
ppnlink |
NLEJ188990437 |
mediatype_str_mv |
z |
isOA_txt |
false |
hochschulschrift_bool |
false |
author2_role |
oth oth oth oth oth |
up_date |
2024-07-06T08:35:04.328Z |
_version_ |
1803818006562734080 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ202686132</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706105317.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1990 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ202686132</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Analysis of early fetal T-cell receptor δ chain in humans</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1990</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract In the mouse it has been found that a number of T-cell receptor (Tcr) gd phenotypes are generated during fetal thymic development. To examine whether such “waves” of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor δ chain in human fetal and post-partum thymocytes and peripheral blood T cells. Using the polymerase chain reaction (PCR)-amplification technique it was found that in fetal thymocytes of 15–17 weeks of gestation the Tcrd-V3 gene segment was mainly employed, whereas in post-partum thymocytes the Tcrd-V1 gene segment was preferentially used. These Tcrd-V3 transcripts contained only a single D element (Dδ3) and a limited random nucleotide insertion. The Dδ3 element was also present in Tcrd-V3-containing transcripts derived from peripheral blood γδ Tcr+ clones. These data suggest that a wave of Tcr γδ might exist early in human fetal development that preferentially use the Tcrd-V3 gene segment.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Stoep, Nienke</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Krijger, Ronald</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bruining, Jan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Koning, Frits</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Elsen, Peter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Immunogenetics</subfield><subfield code="d">1974</subfield><subfield code="g">32(1990) vom: Mai, Seite 331-336</subfield><subfield code="w">(DE-627)NLEJ188990437</subfield><subfield code="w">(DE-600)1398344-1</subfield><subfield code="x">1432-1211</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:32</subfield><subfield code="g">year:1990</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:331-336</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00211647</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">32</subfield><subfield code="j">1990</subfield><subfield code="c">5</subfield><subfield code="h">331-336</subfield><subfield code="g">6</subfield></datafield></record></collection>
|
score |
7.3995056 |