Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography
Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1991 |
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| Umfang: |
6 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
volume:18 ; year:1991 ; month:03 ; pages:158-163 ; extent:6 |
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NLEJ202809536 |
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| 245 | 1 | 0 | |a Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography |
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| 520 | |a Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1. | ||
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(DE-627)NLEJ202809536 DE-627 ger DE-627 rakwb eng Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography 1991 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1. Springer Online Journal Archives 1860-2002 Jovkar, Syd oth Wienhard, Klaus oth Coenen, Heinz H. oth Pawlik, Guenter oth Heiss, Wolf-Dieter oth volume:18 year:1991 month:03 pages:158-163 extent:6 http://dx.doi.org/10.1007/BF02262725 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1991 3 158-163 6 |
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(DE-627)NLEJ202809536 DE-627 ger DE-627 rakwb eng Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography 1991 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1. Springer Online Journal Archives 1860-2002 Jovkar, Syd oth Wienhard, Klaus oth Coenen, Heinz H. oth Pawlik, Guenter oth Heiss, Wolf-Dieter oth volume:18 year:1991 month:03 pages:158-163 extent:6 http://dx.doi.org/10.1007/BF02262725 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1991 3 158-163 6 |
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(DE-627)NLEJ202809536 DE-627 ger DE-627 rakwb eng Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography 1991 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1. Springer Online Journal Archives 1860-2002 Jovkar, Syd oth Wienhard, Klaus oth Coenen, Heinz H. oth Pawlik, Guenter oth Heiss, Wolf-Dieter oth volume:18 year:1991 month:03 pages:158-163 extent:6 http://dx.doi.org/10.1007/BF02262725 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1991 3 158-163 6 |
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(DE-627)NLEJ202809536 DE-627 ger DE-627 rakwb eng Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography 1991 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1. Springer Online Journal Archives 1860-2002 Jovkar, Syd oth Wienhard, Klaus oth Coenen, Heinz H. oth Pawlik, Guenter oth Heiss, Wolf-Dieter oth volume:18 year:1991 month:03 pages:158-163 extent:6 http://dx.doi.org/10.1007/BF02262725 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1991 3 158-163 6 |
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(DE-627)NLEJ202809536 DE-627 ger DE-627 rakwb eng Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography 1991 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1. Springer Online Journal Archives 1860-2002 Jovkar, Syd oth Wienhard, Klaus oth Coenen, Heinz H. oth Pawlik, Guenter oth Heiss, Wolf-Dieter oth volume:18 year:1991 month:03 pages:158-163 extent:6 http://dx.doi.org/10.1007/BF02262725 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1991 3 158-163 6 |
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Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography |
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quantification of baboon cortical s2 serotonin receptors in vivo with 3-n-(2′-fl8)fluoroethylspiperone and positron emission tomography |
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Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography |
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Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1. |
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Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1. |
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Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1. |
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Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ202809536</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706111434.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1991 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ202809536</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1991</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P <0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jovkar, Syd</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wienhard, Klaus</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Coenen, Heinz H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pawlik, Guenter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Heiss, Wolf-Dieter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:18</subfield><subfield code="g">year:1991</subfield><subfield code="g">month:03</subfield><subfield code="g">pages:158-163</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF02262725</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">18</subfield><subfield code="j">1991</subfield><subfield code="c">3</subfield><subfield code="h">158-163</subfield><subfield code="g">6</subfield></datafield></record></collection>
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7.4006405 |