Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones
Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the hum...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1995 |
|---|
| Umfang: |
6 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Cancer immunology immunotherapy - 1976, 41(1995) vom: Jan., Seite 23-28 |
| Übergeordnetes Werk: |
volume:41 ; year:1995 ; month:01 ; pages:23-28 ; extent:6 |
| Links: |
|---|
| Katalog-ID: |
NLEJ202858723 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ202858723 | ||
| 003 | DE-627 | ||
| 005 | 20210706112224.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070528s1995 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ202858723 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones |
| 264 | 1 | |c 1995 | |
| 300 | |a 6 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Lanza, Lorella |4 oth | |
| 700 | 1 | |a Peirano, Lorenza |4 oth | |
| 700 | 1 | |a Bosco, Ornella |4 oth | |
| 700 | 1 | |a Contini, Paola |4 oth | |
| 700 | 1 | |a Filaci, Gilberto |4 oth | |
| 700 | 1 | |a Setti, Maurizio |4 oth | |
| 700 | 1 | |a Puppo, Francesco |4 oth | |
| 700 | 1 | |a Indiveri, Francesco |4 oth | |
| 700 | 1 | |a Scudeletti, Marco |4 oth | |
| 773 | 0 | 8 | |i in |t Cancer immunology immunotherapy |d 1976 |g 41(1995) vom: Jan., Seite 23-28 |w (DE-627)NLEJ188986774 |w (DE-600)1458489-x |x 1432-0851 |7 nnns |
| 773 | 1 | 8 | |g volume:41 |g year:1995 |g month:01 |g pages:23-28 |g extent:6 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF01788956 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 41 |j 1995 |c 1 |h 23-28 |g 6 | ||
| matchkey_str |
article:14320851:1995----::nefrnurgltwtdfeetoechalsinieepesoim4uamlnmcllnpsili |
|---|---|
| hierarchy_sort_str |
1995 |
| publishDate |
1995 |
| allfields |
(DE-627)NLEJ202858723 DE-627 ger DE-627 rakwb eng Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones 1995 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma. Springer Online Journal Archives 1860-2002 Lanza, Lorella oth Peirano, Lorenza oth Bosco, Ornella oth Contini, Paola oth Filaci, Gilberto oth Setti, Maurizio oth Puppo, Francesco oth Indiveri, Francesco oth Scudeletti, Marco oth in Cancer immunology immunotherapy 1976 41(1995) vom: Jan., Seite 23-28 (DE-627)NLEJ188986774 (DE-600)1458489-x 1432-0851 nnns volume:41 year:1995 month:01 pages:23-28 extent:6 http://dx.doi.org/10.1007/BF01788956 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1995 1 23-28 6 |
| spelling |
(DE-627)NLEJ202858723 DE-627 ger DE-627 rakwb eng Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones 1995 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma. Springer Online Journal Archives 1860-2002 Lanza, Lorella oth Peirano, Lorenza oth Bosco, Ornella oth Contini, Paola oth Filaci, Gilberto oth Setti, Maurizio oth Puppo, Francesco oth Indiveri, Francesco oth Scudeletti, Marco oth in Cancer immunology immunotherapy 1976 41(1995) vom: Jan., Seite 23-28 (DE-627)NLEJ188986774 (DE-600)1458489-x 1432-0851 nnns volume:41 year:1995 month:01 pages:23-28 extent:6 http://dx.doi.org/10.1007/BF01788956 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1995 1 23-28 6 |
| allfields_unstemmed |
(DE-627)NLEJ202858723 DE-627 ger DE-627 rakwb eng Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones 1995 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma. Springer Online Journal Archives 1860-2002 Lanza, Lorella oth Peirano, Lorenza oth Bosco, Ornella oth Contini, Paola oth Filaci, Gilberto oth Setti, Maurizio oth Puppo, Francesco oth Indiveri, Francesco oth Scudeletti, Marco oth in Cancer immunology immunotherapy 1976 41(1995) vom: Jan., Seite 23-28 (DE-627)NLEJ188986774 (DE-600)1458489-x 1432-0851 nnns volume:41 year:1995 month:01 pages:23-28 extent:6 http://dx.doi.org/10.1007/BF01788956 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1995 1 23-28 6 |
| allfieldsGer |
(DE-627)NLEJ202858723 DE-627 ger DE-627 rakwb eng Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones 1995 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma. Springer Online Journal Archives 1860-2002 Lanza, Lorella oth Peirano, Lorenza oth Bosco, Ornella oth Contini, Paola oth Filaci, Gilberto oth Setti, Maurizio oth Puppo, Francesco oth Indiveri, Francesco oth Scudeletti, Marco oth in Cancer immunology immunotherapy 1976 41(1995) vom: Jan., Seite 23-28 (DE-627)NLEJ188986774 (DE-600)1458489-x 1432-0851 nnns volume:41 year:1995 month:01 pages:23-28 extent:6 http://dx.doi.org/10.1007/BF01788956 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1995 1 23-28 6 |
| allfieldsSound |
(DE-627)NLEJ202858723 DE-627 ger DE-627 rakwb eng Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones 1995 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma. Springer Online Journal Archives 1860-2002 Lanza, Lorella oth Peirano, Lorenza oth Bosco, Ornella oth Contini, Paola oth Filaci, Gilberto oth Setti, Maurizio oth Puppo, Francesco oth Indiveri, Francesco oth Scudeletti, Marco oth in Cancer immunology immunotherapy 1976 41(1995) vom: Jan., Seite 23-28 (DE-627)NLEJ188986774 (DE-600)1458489-x 1432-0851 nnns volume:41 year:1995 month:01 pages:23-28 extent:6 http://dx.doi.org/10.1007/BF01788956 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1995 1 23-28 6 |
| language |
English |
| source |
in Cancer immunology immunotherapy 41(1995) vom: Jan., Seite 23-28 volume:41 year:1995 month:01 pages:23-28 extent:6 |
| sourceStr |
in Cancer immunology immunotherapy 41(1995) vom: Jan., Seite 23-28 volume:41 year:1995 month:01 pages:23-28 extent:6 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Cancer immunology immunotherapy |
| authorswithroles_txt_mv |
Lanza, Lorella @@oth@@ Peirano, Lorenza @@oth@@ Bosco, Ornella @@oth@@ Contini, Paola @@oth@@ Filaci, Gilberto @@oth@@ Setti, Maurizio @@oth@@ Puppo, Francesco @@oth@@ Indiveri, Francesco @@oth@@ Scudeletti, Marco @@oth@@ |
| publishDateDaySort_date |
1995-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188986774 |
| id |
NLEJ202858723 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ202858723</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706112224.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1995 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ202858723</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lanza, Lorella</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Peirano, Lorenza</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bosco, Ornella</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Contini, Paola</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Filaci, Gilberto</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Setti, Maurizio</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Puppo, Francesco</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Indiveri, Francesco</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Scudeletti, Marco</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Cancer immunology immunotherapy</subfield><subfield code="d">1976</subfield><subfield code="g">41(1995) vom: Jan., Seite 23-28</subfield><subfield code="w">(DE-627)NLEJ188986774</subfield><subfield code="w">(DE-600)1458489-x</subfield><subfield code="x">1432-0851</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:41</subfield><subfield code="g">year:1995</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:23-28</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01788956</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">41</subfield><subfield code="j">1995</subfield><subfield code="c">1</subfield><subfield code="h">23-28</subfield><subfield code="g">6</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188986774 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1432-0851 |
| topic_title |
Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
l l ll l p lp o b ob p c pc g f gf m s ms f p fp f i fi m s ms |
| hierarchy_parent_title |
Cancer immunology immunotherapy |
| hierarchy_parent_id |
NLEJ188986774 |
| hierarchy_top_title |
Cancer immunology immunotherapy |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188986774 (DE-600)1458489-x |
| title |
Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones |
| spellingShingle |
Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones |
| ctrlnum |
(DE-627)NLEJ202858723 |
| title_full |
Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones |
| journal |
Cancer immunology immunotherapy |
| journalStr |
Cancer immunology immunotherapy |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1995 |
| contenttype_str_mv |
zzz |
| container_start_page |
23 |
| container_volume |
41 |
| physical |
6 |
| format_se |
Elektronische Aufsätze |
| title_sort |
interferons up-regulate with different potency hla class i antigen expression in m14 human melanoma cell line. possible interaction with glucocorticoid hormones |
| title_auth |
Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones |
| abstract |
Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma. |
| abstractGer |
Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma. |
| abstract_unstemmed |
Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones |
| url |
http://dx.doi.org/10.1007/BF01788956 |
| remote_bool |
true |
| author2 |
Lanza, Lorella Peirano, Lorenza Bosco, Ornella Contini, Paola Filaci, Gilberto Setti, Maurizio Puppo, Francesco Indiveri, Francesco Scudeletti, Marco |
| author2Str |
Lanza, Lorella Peirano, Lorenza Bosco, Ornella Contini, Paola Filaci, Gilberto Setti, Maurizio Puppo, Francesco Indiveri, Francesco Scudeletti, Marco |
| ppnlink |
NLEJ188986774 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth oth oth |
| up_date |
2024-07-06T09:05:46.447Z |
| _version_ |
1803819938162409473 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ202858723</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706112224.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1995 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ202858723</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lanza, Lorella</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Peirano, Lorenza</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bosco, Ornella</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Contini, Paola</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Filaci, Gilberto</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Setti, Maurizio</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Puppo, Francesco</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Indiveri, Francesco</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Scudeletti, Marco</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Cancer immunology immunotherapy</subfield><subfield code="d">1976</subfield><subfield code="g">41(1995) vom: Jan., Seite 23-28</subfield><subfield code="w">(DE-627)NLEJ188986774</subfield><subfield code="w">(DE-600)1458489-x</subfield><subfield code="x">1432-0851</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:41</subfield><subfield code="g">year:1995</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:23-28</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01788956</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">41</subfield><subfield code="j">1995</subfield><subfield code="c">1</subfield><subfield code="h">23-28</subfield><subfield code="g">6</subfield></datafield></record></collection>
|
| score |
7.399148 |