In vivo cell kinetic effects of vincristine on the spontaneous AKR leukemia: Recruitment of non-proliferating cells
Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mi...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1982 |
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| Umfang: |
7 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Annals of hematology - 1955, 45(1982) vom: Jan., Seite 39-45 |
| Übergeordnetes Werk: |
volume:45 ; year:1982 ; month:01 ; pages:39-45 ; extent:7 |
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NLEJ202956156 |
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| 245 | 1 | 0 | |a In vivo cell kinetic effects of vincristine on the spontaneous AKR leukemia: Recruitment of non-proliferating cells |
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| 520 | |a Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment). | ||
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| 700 | 1 | |a Wilms, K. |4 oth | |
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(DE-627)NLEJ202956156 DE-627 ger DE-627 rakwb eng In vivo cell kinetic effects of vincristine on the spontaneous AKR leukemia: Recruitment of non-proliferating cells 1982 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment). Springer Online Journal Archives 1860-2002 Hiller, K. oth Meyer, P. oth Wilms, K. oth in Annals of hematology 1955 45(1982) vom: Jan., Seite 39-45 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:45 year:1982 month:01 pages:39-45 extent:7 http://dx.doi.org/10.1007/BF00320497 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 45 1982 1 39-45 7 |
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(DE-627)NLEJ202956156 DE-627 ger DE-627 rakwb eng In vivo cell kinetic effects of vincristine on the spontaneous AKR leukemia: Recruitment of non-proliferating cells 1982 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment). Springer Online Journal Archives 1860-2002 Hiller, K. oth Meyer, P. oth Wilms, K. oth in Annals of hematology 1955 45(1982) vom: Jan., Seite 39-45 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:45 year:1982 month:01 pages:39-45 extent:7 http://dx.doi.org/10.1007/BF00320497 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 45 1982 1 39-45 7 |
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(DE-627)NLEJ202956156 DE-627 ger DE-627 rakwb eng In vivo cell kinetic effects of vincristine on the spontaneous AKR leukemia: Recruitment of non-proliferating cells 1982 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment). Springer Online Journal Archives 1860-2002 Hiller, K. oth Meyer, P. oth Wilms, K. oth in Annals of hematology 1955 45(1982) vom: Jan., Seite 39-45 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:45 year:1982 month:01 pages:39-45 extent:7 http://dx.doi.org/10.1007/BF00320497 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 45 1982 1 39-45 7 |
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(DE-627)NLEJ202956156 DE-627 ger DE-627 rakwb eng In vivo cell kinetic effects of vincristine on the spontaneous AKR leukemia: Recruitment of non-proliferating cells 1982 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment). Springer Online Journal Archives 1860-2002 Hiller, K. oth Meyer, P. oth Wilms, K. oth in Annals of hematology 1955 45(1982) vom: Jan., Seite 39-45 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:45 year:1982 month:01 pages:39-45 extent:7 http://dx.doi.org/10.1007/BF00320497 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 45 1982 1 39-45 7 |
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(DE-627)NLEJ202956156 DE-627 ger DE-627 rakwb eng In vivo cell kinetic effects of vincristine on the spontaneous AKR leukemia: Recruitment of non-proliferating cells 1982 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment). Springer Online Journal Archives 1860-2002 Hiller, K. oth Meyer, P. oth Wilms, K. oth in Annals of hematology 1955 45(1982) vom: Jan., Seite 39-45 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:45 year:1982 month:01 pages:39-45 extent:7 http://dx.doi.org/10.1007/BF00320497 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 45 1982 1 39-45 7 |
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in vivo cell kinetic effects of vincristine on the spontaneous akr leukemia: recruitment of non-proliferating cells |
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In vivo cell kinetic effects of vincristine on the spontaneous AKR leukemia: Recruitment of non-proliferating cells |
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Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment). |
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Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment). |
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Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment). |
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