Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation
Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to ev...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1992 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Annals of hematology - 1955, 64(1992) vom: Jan., Seite A140 |
| Übergeordnetes Werk: |
volume:64 ; year:1992 ; month:01 ; pages:A140 |
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| 520 | |a Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions. | ||
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(DE-627)NLEJ202970841 DE-627 ger DE-627 rakwb eng Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions. Springer Online Journal Archives 1860-2002 Müller, C. A. oth Einsele, H. oth in Annals of hematology 1955 64(1992) vom: Jan., Seite A140 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:64 year:1992 month:01 pages:A140 http://dx.doi.org/10.1007/BF01715368 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 64 1992 1 A140 |
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(DE-627)NLEJ202970841 DE-627 ger DE-627 rakwb eng Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions. Springer Online Journal Archives 1860-2002 Müller, C. A. oth Einsele, H. oth in Annals of hematology 1955 64(1992) vom: Jan., Seite A140 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:64 year:1992 month:01 pages:A140 http://dx.doi.org/10.1007/BF01715368 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 64 1992 1 A140 |
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(DE-627)NLEJ202970841 DE-627 ger DE-627 rakwb eng Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions. Springer Online Journal Archives 1860-2002 Müller, C. A. oth Einsele, H. oth in Annals of hematology 1955 64(1992) vom: Jan., Seite A140 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:64 year:1992 month:01 pages:A140 http://dx.doi.org/10.1007/BF01715368 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 64 1992 1 A140 |
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(DE-627)NLEJ202970841 DE-627 ger DE-627 rakwb eng Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions. Springer Online Journal Archives 1860-2002 Müller, C. A. oth Einsele, H. oth in Annals of hematology 1955 64(1992) vom: Jan., Seite A140 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:64 year:1992 month:01 pages:A140 http://dx.doi.org/10.1007/BF01715368 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 64 1992 1 A140 |
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(DE-627)NLEJ202970841 DE-627 ger DE-627 rakwb eng Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions. Springer Online Journal Archives 1860-2002 Müller, C. A. oth Einsele, H. oth in Annals of hematology 1955 64(1992) vom: Jan., Seite A140 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:64 year:1992 month:01 pages:A140 http://dx.doi.org/10.1007/BF01715368 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 64 1992 1 A140 |
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influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation |
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Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation |
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Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions. |
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Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions. |
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Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions. |
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