Chronic lymphocytic leukemia with two cellular populations: a biphenotypic or biclonal disease
Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone m...
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Englisch |
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1997 |
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Springer Online Journal Archives 1860-2002 |
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in: Annals of hematology - 1955, 74(1997) vom: Mai, Seite 243-246 |
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volume:74 ; year:1997 ; month:05 ; pages:243-246 ; extent:4 |
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| 520 | |a Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction. | ||
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(DE-627)NLEJ202979431 DE-627 ger DE-627 rakwb eng Chronic lymphocytic leukemia with two cellular populations: a biphenotypic or biclonal disease 1997 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction. Springer Online Journal Archives 1860-2002 González-Campos, J. oth Ríos-Herranz, E. oth Blas-Orlando, J. M. De oth Martín-Noya, A. oth Parody-Ruiz-Berdejo, R. oth Rodríguez-Fernández, J. M. oth in Annals of hematology 1955 74(1997) vom: Mai, Seite 243-246 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:74 year:1997 month:05 pages:243-246 extent:4 http://dx.doi.org/10.1007/s002770050292 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 74 1997 5 243-246 4 |
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(DE-627)NLEJ202979431 DE-627 ger DE-627 rakwb eng Chronic lymphocytic leukemia with two cellular populations: a biphenotypic or biclonal disease 1997 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction. Springer Online Journal Archives 1860-2002 González-Campos, J. oth Ríos-Herranz, E. oth Blas-Orlando, J. M. De oth Martín-Noya, A. oth Parody-Ruiz-Berdejo, R. oth Rodríguez-Fernández, J. M. oth in Annals of hematology 1955 74(1997) vom: Mai, Seite 243-246 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:74 year:1997 month:05 pages:243-246 extent:4 http://dx.doi.org/10.1007/s002770050292 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 74 1997 5 243-246 4 |
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(DE-627)NLEJ202979431 DE-627 ger DE-627 rakwb eng Chronic lymphocytic leukemia with two cellular populations: a biphenotypic or biclonal disease 1997 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction. Springer Online Journal Archives 1860-2002 González-Campos, J. oth Ríos-Herranz, E. oth Blas-Orlando, J. M. De oth Martín-Noya, A. oth Parody-Ruiz-Berdejo, R. oth Rodríguez-Fernández, J. M. oth in Annals of hematology 1955 74(1997) vom: Mai, Seite 243-246 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:74 year:1997 month:05 pages:243-246 extent:4 http://dx.doi.org/10.1007/s002770050292 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 74 1997 5 243-246 4 |
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(DE-627)NLEJ202979431 DE-627 ger DE-627 rakwb eng Chronic lymphocytic leukemia with two cellular populations: a biphenotypic or biclonal disease 1997 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction. Springer Online Journal Archives 1860-2002 González-Campos, J. oth Ríos-Herranz, E. oth Blas-Orlando, J. M. De oth Martín-Noya, A. oth Parody-Ruiz-Berdejo, R. oth Rodríguez-Fernández, J. M. oth in Annals of hematology 1955 74(1997) vom: Mai, Seite 243-246 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:74 year:1997 month:05 pages:243-246 extent:4 http://dx.doi.org/10.1007/s002770050292 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 74 1997 5 243-246 4 |
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(DE-627)NLEJ202979431 DE-627 ger DE-627 rakwb eng Chronic lymphocytic leukemia with two cellular populations: a biphenotypic or biclonal disease 1997 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction. Springer Online Journal Archives 1860-2002 González-Campos, J. oth Ríos-Herranz, E. oth Blas-Orlando, J. M. De oth Martín-Noya, A. oth Parody-Ruiz-Berdejo, R. oth Rodríguez-Fernández, J. M. oth in Annals of hematology 1955 74(1997) vom: Mai, Seite 243-246 (DE-627)NLEJ18898836X (DE-600)1458429-3 1432-0584 nnns volume:74 year:1997 month:05 pages:243-246 extent:4 http://dx.doi.org/10.1007/s002770050292 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 74 1997 5 243-246 4 |
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Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction. |
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Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction. |
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Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction. |
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2024-07-06T09:26:43.496Z |
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1803821256273821696 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ202979431</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506011259.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1997 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ202979431</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Chronic lymphocytic leukemia with two cellular populations: a biphenotypic or biclonal disease</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim, and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++, and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease. In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence of the presence of at least two monoclonal populations of cells with the same light chain restriction.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">González-Campos, J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ríos-Herranz, E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Blas-Orlando, J. M. De</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Martín-Noya, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Parody-Ruiz-Berdejo, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rodríguez-Fernández, J. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Annals of hematology</subfield><subfield code="d">1955</subfield><subfield code="g">74(1997) vom: Mai, Seite 243-246</subfield><subfield code="w">(DE-627)NLEJ18898836X</subfield><subfield code="w">(DE-600)1458429-3</subfield><subfield code="x">1432-0584</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:74</subfield><subfield code="g">year:1997</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:243-246</subfield><subfield code="g">extent:4</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/s002770050292</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">74</subfield><subfield code="j">1997</subfield><subfield code="c">5</subfield><subfield code="h">243-246</subfield><subfield code="g">4</subfield></datafield></record></collection>
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7.4009714 |