Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays
Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the publ...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1989 |
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| Umfang: |
11 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Cancer chemotherapy and pharmacology - 1978, 23(1989) vom: Apr., Seite 197-207 |
| Übergeordnetes Werk: |
volume:23 ; year:1989 ; month:04 ; pages:197-207 ; extent:11 |
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NLEJ202999084 |
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| 245 | 1 | 0 | |a Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays |
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| 520 | |a Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride. | ||
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(DE-627)NLEJ202999084 DE-627 ger DE-627 rakwb eng Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays 1989 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride. Springer Online Journal Archives 1860-2002 Bosanquet, Andrew G. oth in Cancer chemotherapy and pharmacology 1978 23(1989) vom: Apr., Seite 197-207 (DE-627)NLEJ188987932 (DE-600)1458488-8 1432-0843 nnns volume:23 year:1989 month:04 pages:197-207 extent:11 http://dx.doi.org/10.1007/BF00451642 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 23 1989 4 197-207 11 |
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(DE-627)NLEJ202999084 DE-627 ger DE-627 rakwb eng Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays 1989 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride. Springer Online Journal Archives 1860-2002 Bosanquet, Andrew G. oth in Cancer chemotherapy and pharmacology 1978 23(1989) vom: Apr., Seite 197-207 (DE-627)NLEJ188987932 (DE-600)1458488-8 1432-0843 nnns volume:23 year:1989 month:04 pages:197-207 extent:11 http://dx.doi.org/10.1007/BF00451642 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 23 1989 4 197-207 11 |
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(DE-627)NLEJ202999084 DE-627 ger DE-627 rakwb eng Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays 1989 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride. Springer Online Journal Archives 1860-2002 Bosanquet, Andrew G. oth in Cancer chemotherapy and pharmacology 1978 23(1989) vom: Apr., Seite 197-207 (DE-627)NLEJ188987932 (DE-600)1458488-8 1432-0843 nnns volume:23 year:1989 month:04 pages:197-207 extent:11 http://dx.doi.org/10.1007/BF00451642 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 23 1989 4 197-207 11 |
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(DE-627)NLEJ202999084 DE-627 ger DE-627 rakwb eng Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays 1989 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride. Springer Online Journal Archives 1860-2002 Bosanquet, Andrew G. oth in Cancer chemotherapy and pharmacology 1978 23(1989) vom: Apr., Seite 197-207 (DE-627)NLEJ188987932 (DE-600)1458488-8 1432-0843 nnns volume:23 year:1989 month:04 pages:197-207 extent:11 http://dx.doi.org/10.1007/BF00451642 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 23 1989 4 197-207 11 |
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(DE-627)NLEJ202999084 DE-627 ger DE-627 rakwb eng Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays 1989 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride. Springer Online Journal Archives 1860-2002 Bosanquet, Andrew G. oth in Cancer chemotherapy and pharmacology 1978 23(1989) vom: Apr., Seite 197-207 (DE-627)NLEJ188987932 (DE-600)1458488-8 1432-0843 nnns volume:23 year:1989 month:04 pages:197-207 extent:11 http://dx.doi.org/10.1007/BF00451642 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 23 1989 4 197-207 11 |
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stability of solutions of antineoplastic agents during preparation and storage for in vitro assays |
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Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays |
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Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride. |
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Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride. |
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Summary The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride. |
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