Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type
Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formati...
Ausführliche Beschreibung
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1993 |
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| Umfang: |
5 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Acta neuropathologica - 1961, 85(1993) vom: März, Seite 267-271 |
| Übergeordnetes Werk: |
volume:85 ; year:1993 ; month:03 ; pages:267-271 ; extent:5 |
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NLEJ203608542 |
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| 245 | 1 | 0 | |a Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type |
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| 520 | |a Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes. | ||
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| 700 | 1 | |a Tagliavini, Fabrizio |4 oth | |
| 700 | 1 | |a Giaccone, Giorgio |4 oth | |
| 700 | 1 | |a Bugiani, Orso |4 oth | |
| 700 | 1 | |a Frangione, Blas |4 oth | |
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(DE-627)NLEJ203608542 DE-627 ger DE-627 rakwb eng Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes. Springer Online Journal Archives 1860-2002 Tagliavini, Fabrizio oth Giaccone, Giorgio oth Bugiani, Orso oth Frangione, Blas oth in Acta neuropathologica 1961 85(1993) vom: März, Seite 267-271 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:85 year:1993 month:03 pages:267-271 extent:5 http://dx.doi.org/10.1007/BF00227721 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 85 1993 3 267-271 5 |
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(DE-627)NLEJ203608542 DE-627 ger DE-627 rakwb eng Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes. Springer Online Journal Archives 1860-2002 Tagliavini, Fabrizio oth Giaccone, Giorgio oth Bugiani, Orso oth Frangione, Blas oth in Acta neuropathologica 1961 85(1993) vom: März, Seite 267-271 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:85 year:1993 month:03 pages:267-271 extent:5 http://dx.doi.org/10.1007/BF00227721 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 85 1993 3 267-271 5 |
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(DE-627)NLEJ203608542 DE-627 ger DE-627 rakwb eng Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes. Springer Online Journal Archives 1860-2002 Tagliavini, Fabrizio oth Giaccone, Giorgio oth Bugiani, Orso oth Frangione, Blas oth in Acta neuropathologica 1961 85(1993) vom: März, Seite 267-271 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:85 year:1993 month:03 pages:267-271 extent:5 http://dx.doi.org/10.1007/BF00227721 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 85 1993 3 267-271 5 |
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(DE-627)NLEJ203608542 DE-627 ger DE-627 rakwb eng Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes. Springer Online Journal Archives 1860-2002 Tagliavini, Fabrizio oth Giaccone, Giorgio oth Bugiani, Orso oth Frangione, Blas oth in Acta neuropathologica 1961 85(1993) vom: März, Seite 267-271 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:85 year:1993 month:03 pages:267-271 extent:5 http://dx.doi.org/10.1007/BF00227721 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 85 1993 3 267-271 5 |
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(DE-627)NLEJ203608542 DE-627 ger DE-627 rakwb eng Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes. Springer Online Journal Archives 1860-2002 Tagliavini, Fabrizio oth Giaccone, Giorgio oth Bugiani, Orso oth Frangione, Blas oth in Acta neuropathologica 1961 85(1993) vom: März, Seite 267-271 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:85 year:1993 month:03 pages:267-271 extent:5 http://dx.doi.org/10.1007/BF00227721 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 85 1993 3 267-271 5 |
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in Acta neuropathologica 85(1993) vom: März, Seite 267-271 volume:85 year:1993 month:03 pages:267-271 extent:5 |
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Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type |
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Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type |
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Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes. |
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Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes. |
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Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid β (Aβ) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of Aβ in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that Aβ deposition induces neuritic changes. |
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Ubiquitinated neurites are associated with preamyloid and cerebral amyloid β deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type |
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