Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies
Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically norm...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1993 |
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| Umfang: |
10 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Acta neuropathologica - 1961, 86(1993) vom: März, Seite 265-274 |
| Übergeordnetes Werk: |
volume:86 ; year:1993 ; month:03 ; pages:265-274 ; extent:10 |
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| Katalog-ID: |
NLEJ203609646 |
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| 245 | 1 | 0 | |a Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies |
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| 520 | |a Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically normal Guamanians, dying of causes other than ALS and PD. NFT in brain tissue sections of patients with Guamanian ALS and PD were immunoreactive to antibodies directed against a 43-amino acid synthetic peptide homologous to amyloid β/A4-protein (anti-SP43) associated with Alzheimer's disease. NFT extracted from frozen brain tissues of Guamanian patients with ALS and PD and from tissues of neurologically normal Guamanians were congophilic and birefringent. By negative-stain electron microscopy, NFT preparations contained bundles and/or isolated single, straight, unpaired filaments in Guamanian AlS and occasionally pairing of filaments in neurologically normal Guamanians, measuring 5–20 nm in diameter. Formic acid digestion of NFT preparations, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion high-pressure liquid chromatography, showed a protein with an apparent molecular mass of 4-to 4.5-kDa, which by Western blot analysis was immunoreactive to anti-SP43. Immunoabsorption of purified NFT or SP43 with anti-SP43 abolished immunostaining. Our study corroborate previous data that amyloid β/A4-protein is present in NFT in Guamanian PD. Furthermore, our data indicate that amyloid β/A4-protein is present in NFT in brain tissues of patients with Guamanian ALS and in neurologically normal Gumananians, suggesting a common mechanism of amyloidogenesis with NFT formation in Alzheimer's disease and normal brain aging. | ||
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| 700 | 1 | |a Mellini, M. |4 oth | |
| 700 | 1 | |a Miyazaki, M. |4 oth | |
| 700 | 1 | |a Hilbich, C. |4 oth | |
| 700 | 1 | |a Safar, J. |4 oth | |
| 700 | 1 | |a Garruto, R. M. |4 oth | |
| 700 | 1 | |a Yanagihara, R. |4 oth | |
| 700 | 1 | |a Beyreuther, K. |4 oth | |
| 700 | 1 | |a Gajdusek, D. C. |4 oth | |
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(DE-627)NLEJ203609646 DE-627 ger DE-627 rakwb eng Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies 1993 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically normal Guamanians, dying of causes other than ALS and PD. NFT in brain tissue sections of patients with Guamanian ALS and PD were immunoreactive to antibodies directed against a 43-amino acid synthetic peptide homologous to amyloid β/A4-protein (anti-SP43) associated with Alzheimer's disease. NFT extracted from frozen brain tissues of Guamanian patients with ALS and PD and from tissues of neurologically normal Guamanians were congophilic and birefringent. By negative-stain electron microscopy, NFT preparations contained bundles and/or isolated single, straight, unpaired filaments in Guamanian AlS and occasionally pairing of filaments in neurologically normal Guamanians, measuring 5–20 nm in diameter. Formic acid digestion of NFT preparations, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion high-pressure liquid chromatography, showed a protein with an apparent molecular mass of 4-to 4.5-kDa, which by Western blot analysis was immunoreactive to anti-SP43. Immunoabsorption of purified NFT or SP43 with anti-SP43 abolished immunostaining. Our study corroborate previous data that amyloid β/A4-protein is present in NFT in Guamanian PD. Furthermore, our data indicate that amyloid β/A4-protein is present in NFT in brain tissues of patients with Guamanian ALS and in neurologically normal Gumananians, suggesting a common mechanism of amyloidogenesis with NFT formation in Alzheimer's disease and normal brain aging. Springer Online Journal Archives 1860-2002 Guiroy, D. C. oth Mellini, M. oth Miyazaki, M. oth Hilbich, C. oth Safar, J. oth Garruto, R. M. oth Yanagihara, R. oth Beyreuther, K. oth Gajdusek, D. C. oth in Acta neuropathologica 1961 86(1993) vom: März, Seite 265-274 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:86 year:1993 month:03 pages:265-274 extent:10 http://dx.doi.org/10.1007/BF00304141 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 86 1993 3 265-274 10 |
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(DE-627)NLEJ203609646 DE-627 ger DE-627 rakwb eng Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies 1993 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically normal Guamanians, dying of causes other than ALS and PD. NFT in brain tissue sections of patients with Guamanian ALS and PD were immunoreactive to antibodies directed against a 43-amino acid synthetic peptide homologous to amyloid β/A4-protein (anti-SP43) associated with Alzheimer's disease. NFT extracted from frozen brain tissues of Guamanian patients with ALS and PD and from tissues of neurologically normal Guamanians were congophilic and birefringent. By negative-stain electron microscopy, NFT preparations contained bundles and/or isolated single, straight, unpaired filaments in Guamanian AlS and occasionally pairing of filaments in neurologically normal Guamanians, measuring 5–20 nm in diameter. Formic acid digestion of NFT preparations, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion high-pressure liquid chromatography, showed a protein with an apparent molecular mass of 4-to 4.5-kDa, which by Western blot analysis was immunoreactive to anti-SP43. Immunoabsorption of purified NFT or SP43 with anti-SP43 abolished immunostaining. Our study corroborate previous data that amyloid β/A4-protein is present in NFT in Guamanian PD. Furthermore, our data indicate that amyloid β/A4-protein is present in NFT in brain tissues of patients with Guamanian ALS and in neurologically normal Gumananians, suggesting a common mechanism of amyloidogenesis with NFT formation in Alzheimer's disease and normal brain aging. Springer Online Journal Archives 1860-2002 Guiroy, D. C. oth Mellini, M. oth Miyazaki, M. oth Hilbich, C. oth Safar, J. oth Garruto, R. M. oth Yanagihara, R. oth Beyreuther, K. oth Gajdusek, D. C. oth in Acta neuropathologica 1961 86(1993) vom: März, Seite 265-274 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:86 year:1993 month:03 pages:265-274 extent:10 http://dx.doi.org/10.1007/BF00304141 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 86 1993 3 265-274 10 |
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(DE-627)NLEJ203609646 DE-627 ger DE-627 rakwb eng Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies 1993 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically normal Guamanians, dying of causes other than ALS and PD. NFT in brain tissue sections of patients with Guamanian ALS and PD were immunoreactive to antibodies directed against a 43-amino acid synthetic peptide homologous to amyloid β/A4-protein (anti-SP43) associated with Alzheimer's disease. NFT extracted from frozen brain tissues of Guamanian patients with ALS and PD and from tissues of neurologically normal Guamanians were congophilic and birefringent. By negative-stain electron microscopy, NFT preparations contained bundles and/or isolated single, straight, unpaired filaments in Guamanian AlS and occasionally pairing of filaments in neurologically normal Guamanians, measuring 5–20 nm in diameter. Formic acid digestion of NFT preparations, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion high-pressure liquid chromatography, showed a protein with an apparent molecular mass of 4-to 4.5-kDa, which by Western blot analysis was immunoreactive to anti-SP43. Immunoabsorption of purified NFT or SP43 with anti-SP43 abolished immunostaining. Our study corroborate previous data that amyloid β/A4-protein is present in NFT in Guamanian PD. Furthermore, our data indicate that amyloid β/A4-protein is present in NFT in brain tissues of patients with Guamanian ALS and in neurologically normal Gumananians, suggesting a common mechanism of amyloidogenesis with NFT formation in Alzheimer's disease and normal brain aging. Springer Online Journal Archives 1860-2002 Guiroy, D. C. oth Mellini, M. oth Miyazaki, M. oth Hilbich, C. oth Safar, J. oth Garruto, R. M. oth Yanagihara, R. oth Beyreuther, K. oth Gajdusek, D. C. oth in Acta neuropathologica 1961 86(1993) vom: März, Seite 265-274 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:86 year:1993 month:03 pages:265-274 extent:10 http://dx.doi.org/10.1007/BF00304141 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 86 1993 3 265-274 10 |
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(DE-627)NLEJ203609646 DE-627 ger DE-627 rakwb eng Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies 1993 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically normal Guamanians, dying of causes other than ALS and PD. NFT in brain tissue sections of patients with Guamanian ALS and PD were immunoreactive to antibodies directed against a 43-amino acid synthetic peptide homologous to amyloid β/A4-protein (anti-SP43) associated with Alzheimer's disease. NFT extracted from frozen brain tissues of Guamanian patients with ALS and PD and from tissues of neurologically normal Guamanians were congophilic and birefringent. By negative-stain electron microscopy, NFT preparations contained bundles and/or isolated single, straight, unpaired filaments in Guamanian AlS and occasionally pairing of filaments in neurologically normal Guamanians, measuring 5–20 nm in diameter. Formic acid digestion of NFT preparations, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion high-pressure liquid chromatography, showed a protein with an apparent molecular mass of 4-to 4.5-kDa, which by Western blot analysis was immunoreactive to anti-SP43. Immunoabsorption of purified NFT or SP43 with anti-SP43 abolished immunostaining. Our study corroborate previous data that amyloid β/A4-protein is present in NFT in Guamanian PD. Furthermore, our data indicate that amyloid β/A4-protein is present in NFT in brain tissues of patients with Guamanian ALS and in neurologically normal Gumananians, suggesting a common mechanism of amyloidogenesis with NFT formation in Alzheimer's disease and normal brain aging. Springer Online Journal Archives 1860-2002 Guiroy, D. C. oth Mellini, M. oth Miyazaki, M. oth Hilbich, C. oth Safar, J. oth Garruto, R. M. oth Yanagihara, R. oth Beyreuther, K. oth Gajdusek, D. C. oth in Acta neuropathologica 1961 86(1993) vom: März, Seite 265-274 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:86 year:1993 month:03 pages:265-274 extent:10 http://dx.doi.org/10.1007/BF00304141 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 86 1993 3 265-274 10 |
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(DE-627)NLEJ203609646 DE-627 ger DE-627 rakwb eng Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies 1993 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically normal Guamanians, dying of causes other than ALS and PD. NFT in brain tissue sections of patients with Guamanian ALS and PD were immunoreactive to antibodies directed against a 43-amino acid synthetic peptide homologous to amyloid β/A4-protein (anti-SP43) associated with Alzheimer's disease. NFT extracted from frozen brain tissues of Guamanian patients with ALS and PD and from tissues of neurologically normal Guamanians were congophilic and birefringent. By negative-stain electron microscopy, NFT preparations contained bundles and/or isolated single, straight, unpaired filaments in Guamanian AlS and occasionally pairing of filaments in neurologically normal Guamanians, measuring 5–20 nm in diameter. Formic acid digestion of NFT preparations, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion high-pressure liquid chromatography, showed a protein with an apparent molecular mass of 4-to 4.5-kDa, which by Western blot analysis was immunoreactive to anti-SP43. Immunoabsorption of purified NFT or SP43 with anti-SP43 abolished immunostaining. Our study corroborate previous data that amyloid β/A4-protein is present in NFT in Guamanian PD. Furthermore, our data indicate that amyloid β/A4-protein is present in NFT in brain tissues of patients with Guamanian ALS and in neurologically normal Gumananians, suggesting a common mechanism of amyloidogenesis with NFT formation in Alzheimer's disease and normal brain aging. Springer Online Journal Archives 1860-2002 Guiroy, D. C. oth Mellini, M. oth Miyazaki, M. oth Hilbich, C. oth Safar, J. oth Garruto, R. M. oth Yanagihara, R. oth Beyreuther, K. oth Gajdusek, D. C. oth in Acta neuropathologica 1961 86(1993) vom: März, Seite 265-274 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:86 year:1993 month:03 pages:265-274 extent:10 http://dx.doi.org/10.1007/BF00304141 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 86 1993 3 265-274 10 |
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Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies |
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Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies |
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| format_se |
Elektronische Aufsätze |
| title_sort |
neurofibrillary tangles of guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/a4-protein antibodies |
| title_auth |
Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies |
| abstract |
Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically normal Guamanians, dying of causes other than ALS and PD. NFT in brain tissue sections of patients with Guamanian ALS and PD were immunoreactive to antibodies directed against a 43-amino acid synthetic peptide homologous to amyloid β/A4-protein (anti-SP43) associated with Alzheimer's disease. NFT extracted from frozen brain tissues of Guamanian patients with ALS and PD and from tissues of neurologically normal Guamanians were congophilic and birefringent. By negative-stain electron microscopy, NFT preparations contained bundles and/or isolated single, straight, unpaired filaments in Guamanian AlS and occasionally pairing of filaments in neurologically normal Guamanians, measuring 5–20 nm in diameter. Formic acid digestion of NFT preparations, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion high-pressure liquid chromatography, showed a protein with an apparent molecular mass of 4-to 4.5-kDa, which by Western blot analysis was immunoreactive to anti-SP43. Immunoabsorption of purified NFT or SP43 with anti-SP43 abolished immunostaining. Our study corroborate previous data that amyloid β/A4-protein is present in NFT in Guamanian PD. Furthermore, our data indicate that amyloid β/A4-protein is present in NFT in brain tissues of patients with Guamanian ALS and in neurologically normal Gumananians, suggesting a common mechanism of amyloidogenesis with NFT formation in Alzheimer's disease and normal brain aging. |
| abstractGer |
Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically normal Guamanians, dying of causes other than ALS and PD. NFT in brain tissue sections of patients with Guamanian ALS and PD were immunoreactive to antibodies directed against a 43-amino acid synthetic peptide homologous to amyloid β/A4-protein (anti-SP43) associated with Alzheimer's disease. NFT extracted from frozen brain tissues of Guamanian patients with ALS and PD and from tissues of neurologically normal Guamanians were congophilic and birefringent. By negative-stain electron microscopy, NFT preparations contained bundles and/or isolated single, straight, unpaired filaments in Guamanian AlS and occasionally pairing of filaments in neurologically normal Guamanians, measuring 5–20 nm in diameter. Formic acid digestion of NFT preparations, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion high-pressure liquid chromatography, showed a protein with an apparent molecular mass of 4-to 4.5-kDa, which by Western blot analysis was immunoreactive to anti-SP43. Immunoabsorption of purified NFT or SP43 with anti-SP43 abolished immunostaining. Our study corroborate previous data that amyloid β/A4-protein is present in NFT in Guamanian PD. Furthermore, our data indicate that amyloid β/A4-protein is present in NFT in brain tissues of patients with Guamanian ALS and in neurologically normal Gumananians, suggesting a common mechanism of amyloidogenesis with NFT formation in Alzheimer's disease and normal brain aging. |
| abstract_unstemmed |
Summary Neurofibrillary tangles (NFT), one of the neurodegenerative features of Alzheimer's disease, Down's syndrome and normal aging, is a constant, widespread neuropathological finding in Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism-dementia (PD) and in neurologically normal Guamanians, dying of causes other than ALS and PD. NFT in brain tissue sections of patients with Guamanian ALS and PD were immunoreactive to antibodies directed against a 43-amino acid synthetic peptide homologous to amyloid β/A4-protein (anti-SP43) associated with Alzheimer's disease. NFT extracted from frozen brain tissues of Guamanian patients with ALS and PD and from tissues of neurologically normal Guamanians were congophilic and birefringent. By negative-stain electron microscopy, NFT preparations contained bundles and/or isolated single, straight, unpaired filaments in Guamanian AlS and occasionally pairing of filaments in neurologically normal Guamanians, measuring 5–20 nm in diameter. Formic acid digestion of NFT preparations, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion high-pressure liquid chromatography, showed a protein with an apparent molecular mass of 4-to 4.5-kDa, which by Western blot analysis was immunoreactive to anti-SP43. Immunoabsorption of purified NFT or SP43 with anti-SP43 abolished immunostaining. Our study corroborate previous data that amyloid β/A4-protein is present in NFT in Guamanian PD. Furthermore, our data indicate that amyloid β/A4-protein is present in NFT in brain tissues of patients with Guamanian ALS and in neurologically normal Gumananians, suggesting a common mechanism of amyloidogenesis with NFT formation in Alzheimer's disease and normal brain aging. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies |
| url |
http://dx.doi.org/10.1007/BF00304141 |
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true |
| author2 |
Guiroy, D. C. Mellini, M. Miyazaki, M. Hilbich, C. Safar, J. Garruto, R. M. Yanagihara, R. Beyreuther, K. Gajdusek, D. C. |
| author2Str |
Guiroy, D. C. Mellini, M. Miyazaki, M. Hilbich, C. Safar, J. Garruto, R. M. Yanagihara, R. Beyreuther, K. Gajdusek, D. C. |
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| up_date |
2024-07-05T21:56:40.014Z |
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7.4027834 |