Docetaxel neuropathy: a distal axonopathy
Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysi...
Ausführliche Beschreibung
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1999 |
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| Umfang: |
3 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Acta neuropathologica - 1961, 98(1999) vom: Juni, Seite 651-653 |
| Übergeordnetes Werk: |
volume:98 ; year:1999 ; month:06 ; pages:651-653 ; extent:3 |
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| 520 | |a Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. | ||
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| 700 | 1 | |a Bordogna, Gianni |4 oth | |
| 700 | 1 | |a Villa, Eugenio |4 oth | |
| 700 | 1 | |a Previtali, Stefano |4 oth | |
| 700 | 1 | |a Canal, Nicola |4 oth | |
| 700 | 1 | |a Nemni, Raffaello |4 oth | |
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(DE-627)NLEJ203625161 DE-627 ger DE-627 rakwb eng Docetaxel neuropathy: a distal axonopathy 1999 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. Springer Online Journal Archives 1860-2002 Fazio, Raffaella oth Quattrini, A. oth Bolognesi, Angelo oth Bordogna, Gianni oth Villa, Eugenio oth Previtali, Stefano oth Canal, Nicola oth Nemni, Raffaello oth in Acta neuropathologica 1961 98(1999) vom: Juni, Seite 651-653 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:98 year:1999 month:06 pages:651-653 extent:3 http://dx.doi.org/10.1007/s004010051132 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 98 1999 6 651-653 3 |
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(DE-627)NLEJ203625161 DE-627 ger DE-627 rakwb eng Docetaxel neuropathy: a distal axonopathy 1999 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. Springer Online Journal Archives 1860-2002 Fazio, Raffaella oth Quattrini, A. oth Bolognesi, Angelo oth Bordogna, Gianni oth Villa, Eugenio oth Previtali, Stefano oth Canal, Nicola oth Nemni, Raffaello oth in Acta neuropathologica 1961 98(1999) vom: Juni, Seite 651-653 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:98 year:1999 month:06 pages:651-653 extent:3 http://dx.doi.org/10.1007/s004010051132 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 98 1999 6 651-653 3 |
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(DE-627)NLEJ203625161 DE-627 ger DE-627 rakwb eng Docetaxel neuropathy: a distal axonopathy 1999 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. Springer Online Journal Archives 1860-2002 Fazio, Raffaella oth Quattrini, A. oth Bolognesi, Angelo oth Bordogna, Gianni oth Villa, Eugenio oth Previtali, Stefano oth Canal, Nicola oth Nemni, Raffaello oth in Acta neuropathologica 1961 98(1999) vom: Juni, Seite 651-653 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:98 year:1999 month:06 pages:651-653 extent:3 http://dx.doi.org/10.1007/s004010051132 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 98 1999 6 651-653 3 |
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(DE-627)NLEJ203625161 DE-627 ger DE-627 rakwb eng Docetaxel neuropathy: a distal axonopathy 1999 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. Springer Online Journal Archives 1860-2002 Fazio, Raffaella oth Quattrini, A. oth Bolognesi, Angelo oth Bordogna, Gianni oth Villa, Eugenio oth Previtali, Stefano oth Canal, Nicola oth Nemni, Raffaello oth in Acta neuropathologica 1961 98(1999) vom: Juni, Seite 651-653 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:98 year:1999 month:06 pages:651-653 extent:3 http://dx.doi.org/10.1007/s004010051132 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 98 1999 6 651-653 3 |
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(DE-627)NLEJ203625161 DE-627 ger DE-627 rakwb eng Docetaxel neuropathy: a distal axonopathy 1999 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. Springer Online Journal Archives 1860-2002 Fazio, Raffaella oth Quattrini, A. oth Bolognesi, Angelo oth Bordogna, Gianni oth Villa, Eugenio oth Previtali, Stefano oth Canal, Nicola oth Nemni, Raffaello oth in Acta neuropathologica 1961 98(1999) vom: Juni, Seite 651-653 (DE-627)NLEJ188990917 (DE-600)1458410-4 1432-0533 nnns volume:98 year:1999 month:06 pages:651-653 extent:3 http://dx.doi.org/10.1007/s004010051132 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 98 1999 6 651-653 3 |
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Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. |
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Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. |
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Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. |
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