Functional defect in cells involved in Langerhans cell histiocytosis
Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of norm...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1995 |
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| Umfang: |
5 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Archives of dermatological research - 1869, 287(1995) vom: Juli, Seite 627-631 |
| Übergeordnetes Werk: |
volume:287 ; year:1995 ; month:07 ; pages:627-631 ; extent:5 |
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NLEJ203797469 |
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| 520 | |a Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s). | ||
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(DE-627)NLEJ203797469 DE-627 ger DE-627 rakwb eng Functional defect in cells involved in Langerhans cell histiocytosis 1995 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s). Springer Online Journal Archives 1860-2002 Yu, Raymond C. oth Alaibac, Mauro oth Chu, Anthony C. oth in Archives of dermatological research 1869 287(1995) vom: Juli, Seite 627-631 (DE-627)NLEJ188993436 (DE-600)1458448-7 1432-069X nnns volume:287 year:1995 month:07 pages:627-631 extent:5 http://dx.doi.org/10.1007/BF00371733 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 287 1995 7 627-631 5 |
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(DE-627)NLEJ203797469 DE-627 ger DE-627 rakwb eng Functional defect in cells involved in Langerhans cell histiocytosis 1995 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s). Springer Online Journal Archives 1860-2002 Yu, Raymond C. oth Alaibac, Mauro oth Chu, Anthony C. oth in Archives of dermatological research 1869 287(1995) vom: Juli, Seite 627-631 (DE-627)NLEJ188993436 (DE-600)1458448-7 1432-069X nnns volume:287 year:1995 month:07 pages:627-631 extent:5 http://dx.doi.org/10.1007/BF00371733 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 287 1995 7 627-631 5 |
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(DE-627)NLEJ203797469 DE-627 ger DE-627 rakwb eng Functional defect in cells involved in Langerhans cell histiocytosis 1995 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s). Springer Online Journal Archives 1860-2002 Yu, Raymond C. oth Alaibac, Mauro oth Chu, Anthony C. oth in Archives of dermatological research 1869 287(1995) vom: Juli, Seite 627-631 (DE-627)NLEJ188993436 (DE-600)1458448-7 1432-069X nnns volume:287 year:1995 month:07 pages:627-631 extent:5 http://dx.doi.org/10.1007/BF00371733 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 287 1995 7 627-631 5 |
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(DE-627)NLEJ203797469 DE-627 ger DE-627 rakwb eng Functional defect in cells involved in Langerhans cell histiocytosis 1995 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s). Springer Online Journal Archives 1860-2002 Yu, Raymond C. oth Alaibac, Mauro oth Chu, Anthony C. oth in Archives of dermatological research 1869 287(1995) vom: Juli, Seite 627-631 (DE-627)NLEJ188993436 (DE-600)1458448-7 1432-069X nnns volume:287 year:1995 month:07 pages:627-631 extent:5 http://dx.doi.org/10.1007/BF00371733 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 287 1995 7 627-631 5 |
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(DE-627)NLEJ203797469 DE-627 ger DE-627 rakwb eng Functional defect in cells involved in Langerhans cell histiocytosis 1995 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s). Springer Online Journal Archives 1860-2002 Yu, Raymond C. oth Alaibac, Mauro oth Chu, Anthony C. oth in Archives of dermatological research 1869 287(1995) vom: Juli, Seite 627-631 (DE-627)NLEJ188993436 (DE-600)1458448-7 1432-069X nnns volume:287 year:1995 month:07 pages:627-631 extent:5 http://dx.doi.org/10.1007/BF00371733 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 287 1995 7 627-631 5 |
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Functional defect in cells involved in Langerhans cell histiocytosis |
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Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s). |
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Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s). |
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Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s). |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ203797469</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506161047.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1995 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ203797469</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Functional defect in cells involved in Langerhans cell histiocytosis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">5</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The characteristic cell type involved in Langerhans cell histiocytosis, ‘LCH cells’, express most of the enzyme histochemical and immunocytochemical markers of normal epidermal Langerhans cells. It is not known, however, whether these LCH cells express the functional characteristics of normal epidermal Langerhans cells. We studied the alloantigen-presenting activity of LCH cells derived from lesional sites of three patients with the disease. Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction. Compared to epidermal Langerhans cells from healthy controls, LCH cells showed minimal alloantigen-presenting activity on a per-cell basis. The diminished activity was not reversed by exogenous prostaglandin synthetase inhibitor or recombinant human IL-1β. This study confirms our previous report of a child, with fatal multi-system Langerhans cell histiocytosis suggesting that this disease represents a condition in which functionally defective cells of Langerhans cell phenotype accumulate and/or proliferate in various tissues. We postulate that the functional defect is a primary defect of these LCH cells that have acquired an as-yet-undetermined biological insult(s).</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yu, Raymond C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alaibac, Mauro</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chu, Anthony C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Archives of dermatological research</subfield><subfield code="d">1869</subfield><subfield code="g">287(1995) vom: Juli, Seite 627-631</subfield><subfield code="w">(DE-627)NLEJ188993436</subfield><subfield code="w">(DE-600)1458448-7</subfield><subfield code="x">1432-069X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:287</subfield><subfield code="g">year:1995</subfield><subfield code="g">month:07</subfield><subfield code="g">pages:627-631</subfield><subfield code="g">extent:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00371733</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">287</subfield><subfield code="j">1995</subfield><subfield code="c">7</subfield><subfield code="h">627-631</subfield><subfield code="g">5</subfield></datafield></record></collection>
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