An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma
Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA f...
Ausführliche Beschreibung
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1993 |
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| Umfang: |
4 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: European archives of oto-rhino-laryngology and head & neck - 1864, 250(1993) vom: Mai, Seite 277-280 |
| Übergeordnetes Werk: |
volume:250 ; year:1993 ; month:05 ; pages:277-280 ; extent:4 |
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NLEJ204048737 |
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| 520 | |a Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients. | ||
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| 700 | 1 | |a Mezger, J. |4 oth | |
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(DE-627)NLEJ204048737 DE-627 ger DE-627 rakwb eng An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma 1993 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients. Springer Online Journal Archives 1860-2002 Issing, W. J. oth Wustrow, T. P. U. oth Oeckler, R. oth Mezger, J. oth Nerlich, A. oth in European archives of oto-rhino-laryngology and head & neck 1864 250(1993) vom: Mai, Seite 277-280 (DE-627)NLEJ188986693 (DE-600)1459042-6 1434-4726 nnns volume:250 year:1993 month:05 pages:277-280 extent:4 http://dx.doi.org/10.1007/BF00186225 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 250 1993 5 277-280 4 |
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(DE-627)NLEJ204048737 DE-627 ger DE-627 rakwb eng An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma 1993 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients. Springer Online Journal Archives 1860-2002 Issing, W. J. oth Wustrow, T. P. U. oth Oeckler, R. oth Mezger, J. oth Nerlich, A. oth in European archives of oto-rhino-laryngology and head & neck 1864 250(1993) vom: Mai, Seite 277-280 (DE-627)NLEJ188986693 (DE-600)1459042-6 1434-4726 nnns volume:250 year:1993 month:05 pages:277-280 extent:4 http://dx.doi.org/10.1007/BF00186225 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 250 1993 5 277-280 4 |
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(DE-627)NLEJ204048737 DE-627 ger DE-627 rakwb eng An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma 1993 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients. Springer Online Journal Archives 1860-2002 Issing, W. J. oth Wustrow, T. P. U. oth Oeckler, R. oth Mezger, J. oth Nerlich, A. oth in European archives of oto-rhino-laryngology and head & neck 1864 250(1993) vom: Mai, Seite 277-280 (DE-627)NLEJ188986693 (DE-600)1459042-6 1434-4726 nnns volume:250 year:1993 month:05 pages:277-280 extent:4 http://dx.doi.org/10.1007/BF00186225 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 250 1993 5 277-280 4 |
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(DE-627)NLEJ204048737 DE-627 ger DE-627 rakwb eng An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma 1993 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients. Springer Online Journal Archives 1860-2002 Issing, W. J. oth Wustrow, T. P. U. oth Oeckler, R. oth Mezger, J. oth Nerlich, A. oth in European archives of oto-rhino-laryngology and head & neck 1864 250(1993) vom: Mai, Seite 277-280 (DE-627)NLEJ188986693 (DE-600)1459042-6 1434-4726 nnns volume:250 year:1993 month:05 pages:277-280 extent:4 http://dx.doi.org/10.1007/BF00186225 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 250 1993 5 277-280 4 |
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(DE-627)NLEJ204048737 DE-627 ger DE-627 rakwb eng An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma 1993 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients. Springer Online Journal Archives 1860-2002 Issing, W. J. oth Wustrow, T. P. U. oth Oeckler, R. oth Mezger, J. oth Nerlich, A. oth in European archives of oto-rhino-laryngology and head & neck 1864 250(1993) vom: Mai, Seite 277-280 (DE-627)NLEJ188986693 (DE-600)1459042-6 1434-4726 nnns volume:250 year:1993 month:05 pages:277-280 extent:4 http://dx.doi.org/10.1007/BF00186225 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 250 1993 5 277-280 4 |
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an association of the rb gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma |
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An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma |
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Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients. |
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Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients. |
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Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients. |
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