Comparative study of G2 delay and survival after241Americium-α and60Cobalt-γ irradiation
Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For bot...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1982 |
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| Umfang: |
15 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Radiation and environmental biophysics - 1963, 20(1982) vom: März, Seite 171-185 |
| Übergeordnetes Werk: |
volume:20 ; year:1982 ; month:03 ; pages:171-185 ; extent:15 |
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NLEJ204130697 |
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| 520 | |a Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. | ||
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(DE-627)NLEJ204130697 DE-627 ger DE-627 rakwb eng Comparative study of G2 delay and survival after241Americium-α and60Cobalt-γ irradiation 1982 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. Springer Online Journal Archives 1860-2002 Lücke-Huhle, C. oth Comper, W. oth Hieber, L. oth Pech, M. oth in Radiation and environmental biophysics 1963 20(1982) vom: März, Seite 171-185 (DE-627)NLEJ188988556 (DE-600)1462083-2 1432-2099 nnns volume:20 year:1982 month:03 pages:171-185 extent:15 http://dx.doi.org/10.1007/BF01325466 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 20 1982 3 171-185 15 |
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(DE-627)NLEJ204130697 DE-627 ger DE-627 rakwb eng Comparative study of G2 delay and survival after241Americium-α and60Cobalt-γ irradiation 1982 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. Springer Online Journal Archives 1860-2002 Lücke-Huhle, C. oth Comper, W. oth Hieber, L. oth Pech, M. oth in Radiation and environmental biophysics 1963 20(1982) vom: März, Seite 171-185 (DE-627)NLEJ188988556 (DE-600)1462083-2 1432-2099 nnns volume:20 year:1982 month:03 pages:171-185 extent:15 http://dx.doi.org/10.1007/BF01325466 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 20 1982 3 171-185 15 |
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(DE-627)NLEJ204130697 DE-627 ger DE-627 rakwb eng Comparative study of G2 delay and survival after241Americium-α and60Cobalt-γ irradiation 1982 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. Springer Online Journal Archives 1860-2002 Lücke-Huhle, C. oth Comper, W. oth Hieber, L. oth Pech, M. oth in Radiation and environmental biophysics 1963 20(1982) vom: März, Seite 171-185 (DE-627)NLEJ188988556 (DE-600)1462083-2 1432-2099 nnns volume:20 year:1982 month:03 pages:171-185 extent:15 http://dx.doi.org/10.1007/BF01325466 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 20 1982 3 171-185 15 |
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(DE-627)NLEJ204130697 DE-627 ger DE-627 rakwb eng Comparative study of G2 delay and survival after241Americium-α and60Cobalt-γ irradiation 1982 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. Springer Online Journal Archives 1860-2002 Lücke-Huhle, C. oth Comper, W. oth Hieber, L. oth Pech, M. oth in Radiation and environmental biophysics 1963 20(1982) vom: März, Seite 171-185 (DE-627)NLEJ188988556 (DE-600)1462083-2 1432-2099 nnns volume:20 year:1982 month:03 pages:171-185 extent:15 http://dx.doi.org/10.1007/BF01325466 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 20 1982 3 171-185 15 |
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(DE-627)NLEJ204130697 DE-627 ger DE-627 rakwb eng Comparative study of G2 delay and survival after241Americium-α and60Cobalt-γ irradiation 1982 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. Springer Online Journal Archives 1860-2002 Lücke-Huhle, C. oth Comper, W. oth Hieber, L. oth Pech, M. oth in Radiation and environmental biophysics 1963 20(1982) vom: März, Seite 171-185 (DE-627)NLEJ188988556 (DE-600)1462083-2 1432-2099 nnns volume:20 year:1982 month:03 pages:171-185 extent:15 http://dx.doi.org/10.1007/BF01325466 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 20 1982 3 171-185 15 |
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comparative study of g2 delay and survival after241americium-α and60cobalt-γ irradiation |
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Comparative study of G2 delay and survival after241Americium-α and60Cobalt-γ irradiation |
| abstract |
Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. |
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Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. |
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Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ204130697</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706143648.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1982 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ204130697</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Comparative study of G2 delay and survival after241Americium-α and60Cobalt-γ irradiation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1982</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">15</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary Survival and G2 delay following exposure to either60Cobalt-γ-rays or241Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE α ) but higher compared to the ratio of mean inactivation doses $$\left( {RB_{\bar DML} } \right)$$ . Ataxia cells were particularly sensitive to cell killing byγ-irradiation (D37 = 0.57 Gy), however, showed average sensitivity toα-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lücke-Huhle, C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Comper, W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hieber, L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pech, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Radiation and environmental biophysics</subfield><subfield code="d">1963</subfield><subfield code="g">20(1982) vom: März, Seite 171-185</subfield><subfield code="w">(DE-627)NLEJ188988556</subfield><subfield code="w">(DE-600)1462083-2</subfield><subfield code="x">1432-2099</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:20</subfield><subfield code="g">year:1982</subfield><subfield code="g">month:03</subfield><subfield code="g">pages:171-185</subfield><subfield code="g">extent:15</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01325466</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">20</subfield><subfield code="j">1982</subfield><subfield code="c">3</subfield><subfield code="h">171-185</subfield><subfield code="g">15</subfield></datafield></record></collection>
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