Hypoxia precedes the development of experimental preretinal neovascularization
Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1996 |
|---|
| Umfang: |
4 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Graefe's archive for clinical and experimental ophthalmology - 1854, 234(1996) vom: Jan., Seite 43-46 |
| Übergeordnetes Werk: |
volume:234 ; year:1996 ; month:01 ; pages:43-46 ; extent:4 |
| Links: |
|---|
| Katalog-ID: |
NLEJ204333849 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ204333849 | ||
| 003 | DE-627 | ||
| 005 | 20210706150730.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070528s1996 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ204333849 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Hypoxia precedes the development of experimental preretinal neovascularization |
| 264 | 1 | |c 1996 | |
| 300 | |a 4 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Handa, James T. |4 oth | |
| 700 | 1 | |a Berkowitz, Bruce A. |4 oth | |
| 700 | 1 | |a Wilson, Charles A. |4 oth | |
| 700 | 1 | |a Ando, Noburo |4 oth | |
| 700 | 1 | |a Sen, Harsha A. |4 oth | |
| 700 | 1 | |a Jaffe, Glenn J. |4 oth | |
| 773 | 0 | 8 | |i in |t Graefe's archive for clinical and experimental ophthalmology |d 1854 |g 234(1996) vom: Jan., Seite 43-46 |w (DE-627)NLEJ188993738 |w (DE-600)1459159-5 |x 1435-702X |7 nnns |
| 773 | 1 | 8 | |g volume:234 |g year:1996 |g month:01 |g pages:43-46 |g extent:4 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF00186517 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 234 |j 1996 |c 1 |h 43-46 |g 4 | ||
| matchkey_str |
article:1435702X:1996----::yoipeeeteeeomnoeprmnapeei |
|---|---|
| hierarchy_sort_str |
1996 |
| publishDate |
1996 |
| allfields |
(DE-627)NLEJ204333849 DE-627 ger DE-627 rakwb eng Hypoxia precedes the development of experimental preretinal neovascularization 1996 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye. Springer Online Journal Archives 1860-2002 Handa, James T. oth Berkowitz, Bruce A. oth Wilson, Charles A. oth Ando, Noburo oth Sen, Harsha A. oth Jaffe, Glenn J. oth in Graefe's archive for clinical and experimental ophthalmology 1854 234(1996) vom: Jan., Seite 43-46 (DE-627)NLEJ188993738 (DE-600)1459159-5 1435-702X nnns volume:234 year:1996 month:01 pages:43-46 extent:4 http://dx.doi.org/10.1007/BF00186517 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 234 1996 1 43-46 4 |
| spelling |
(DE-627)NLEJ204333849 DE-627 ger DE-627 rakwb eng Hypoxia precedes the development of experimental preretinal neovascularization 1996 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye. Springer Online Journal Archives 1860-2002 Handa, James T. oth Berkowitz, Bruce A. oth Wilson, Charles A. oth Ando, Noburo oth Sen, Harsha A. oth Jaffe, Glenn J. oth in Graefe's archive for clinical and experimental ophthalmology 1854 234(1996) vom: Jan., Seite 43-46 (DE-627)NLEJ188993738 (DE-600)1459159-5 1435-702X nnns volume:234 year:1996 month:01 pages:43-46 extent:4 http://dx.doi.org/10.1007/BF00186517 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 234 1996 1 43-46 4 |
| allfields_unstemmed |
(DE-627)NLEJ204333849 DE-627 ger DE-627 rakwb eng Hypoxia precedes the development of experimental preretinal neovascularization 1996 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye. Springer Online Journal Archives 1860-2002 Handa, James T. oth Berkowitz, Bruce A. oth Wilson, Charles A. oth Ando, Noburo oth Sen, Harsha A. oth Jaffe, Glenn J. oth in Graefe's archive for clinical and experimental ophthalmology 1854 234(1996) vom: Jan., Seite 43-46 (DE-627)NLEJ188993738 (DE-600)1459159-5 1435-702X nnns volume:234 year:1996 month:01 pages:43-46 extent:4 http://dx.doi.org/10.1007/BF00186517 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 234 1996 1 43-46 4 |
| allfieldsGer |
(DE-627)NLEJ204333849 DE-627 ger DE-627 rakwb eng Hypoxia precedes the development of experimental preretinal neovascularization 1996 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye. Springer Online Journal Archives 1860-2002 Handa, James T. oth Berkowitz, Bruce A. oth Wilson, Charles A. oth Ando, Noburo oth Sen, Harsha A. oth Jaffe, Glenn J. oth in Graefe's archive for clinical and experimental ophthalmology 1854 234(1996) vom: Jan., Seite 43-46 (DE-627)NLEJ188993738 (DE-600)1459159-5 1435-702X nnns volume:234 year:1996 month:01 pages:43-46 extent:4 http://dx.doi.org/10.1007/BF00186517 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 234 1996 1 43-46 4 |
| allfieldsSound |
(DE-627)NLEJ204333849 DE-627 ger DE-627 rakwb eng Hypoxia precedes the development of experimental preretinal neovascularization 1996 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye. Springer Online Journal Archives 1860-2002 Handa, James T. oth Berkowitz, Bruce A. oth Wilson, Charles A. oth Ando, Noburo oth Sen, Harsha A. oth Jaffe, Glenn J. oth in Graefe's archive for clinical and experimental ophthalmology 1854 234(1996) vom: Jan., Seite 43-46 (DE-627)NLEJ188993738 (DE-600)1459159-5 1435-702X nnns volume:234 year:1996 month:01 pages:43-46 extent:4 http://dx.doi.org/10.1007/BF00186517 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 234 1996 1 43-46 4 |
| language |
English |
| source |
in Graefe's archive for clinical and experimental ophthalmology 234(1996) vom: Jan., Seite 43-46 volume:234 year:1996 month:01 pages:43-46 extent:4 |
| sourceStr |
in Graefe's archive for clinical and experimental ophthalmology 234(1996) vom: Jan., Seite 43-46 volume:234 year:1996 month:01 pages:43-46 extent:4 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Graefe's archive for clinical and experimental ophthalmology |
| authorswithroles_txt_mv |
Handa, James T. @@oth@@ Berkowitz, Bruce A. @@oth@@ Wilson, Charles A. @@oth@@ Ando, Noburo @@oth@@ Sen, Harsha A. @@oth@@ Jaffe, Glenn J. @@oth@@ |
| publishDateDaySort_date |
1996-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188993738 |
| id |
NLEJ204333849 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ204333849</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706150730.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1996 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ204333849</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hypoxia precedes the development of experimental preretinal neovascularization</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1996</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Handa, James T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Berkowitz, Bruce A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wilson, Charles A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ando, Noburo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sen, Harsha A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jaffe, Glenn J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Graefe's archive for clinical and experimental ophthalmology</subfield><subfield code="d">1854</subfield><subfield code="g">234(1996) vom: Jan., Seite 43-46</subfield><subfield code="w">(DE-627)NLEJ188993738</subfield><subfield code="w">(DE-600)1459159-5</subfield><subfield code="x">1435-702X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:234</subfield><subfield code="g">year:1996</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:43-46</subfield><subfield code="g">extent:4</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00186517</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">234</subfield><subfield code="j">1996</subfield><subfield code="c">1</subfield><subfield code="h">43-46</subfield><subfield code="g">4</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188993738 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1435-702X |
| topic_title |
Hypoxia precedes the development of experimental preretinal neovascularization |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
j t h jt jth b a b ba bab c a w ca caw n a na h a s ha has g j j gj gjj |
| hierarchy_parent_title |
Graefe's archive for clinical and experimental ophthalmology |
| hierarchy_parent_id |
NLEJ188993738 |
| hierarchy_top_title |
Graefe's archive for clinical and experimental ophthalmology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188993738 (DE-600)1459159-5 |
| title |
Hypoxia precedes the development of experimental preretinal neovascularization |
| spellingShingle |
Hypoxia precedes the development of experimental preretinal neovascularization |
| ctrlnum |
(DE-627)NLEJ204333849 |
| title_full |
Hypoxia precedes the development of experimental preretinal neovascularization |
| journal |
Graefe's archive for clinical and experimental ophthalmology |
| journalStr |
Graefe's archive for clinical and experimental ophthalmology |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1996 |
| contenttype_str_mv |
zzz |
| container_start_page |
43 |
| container_volume |
234 |
| physical |
4 |
| format_se |
Elektronische Aufsätze |
| title_sort |
hypoxia precedes the development of experimental preretinal neovascularization |
| title_auth |
Hypoxia precedes the development of experimental preretinal neovascularization |
| abstract |
Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye. |
| abstractGer |
Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye. |
| abstract_unstemmed |
Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Hypoxia precedes the development of experimental preretinal neovascularization |
| url |
http://dx.doi.org/10.1007/BF00186517 |
| remote_bool |
true |
| author2 |
Handa, James T. Berkowitz, Bruce A. Wilson, Charles A. Ando, Noburo Sen, Harsha A. Jaffe, Glenn J. |
| author2Str |
Handa, James T. Berkowitz, Bruce A. Wilson, Charles A. Ando, Noburo Sen, Harsha A. Jaffe, Glenn J. |
| ppnlink |
NLEJ188993738 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth |
| up_date |
2024-07-06T00:19:52.965Z |
| _version_ |
1803786851942662144 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ204333849</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706150730.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1996 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ204333849</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hypoxia precedes the development of experimental preretinal neovascularization</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1996</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract • Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior to the development of preretinal neovascularization in the cell-injected rabbit eye. • Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow (control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using19F-NMR spectroscopy of a 30-μl droplet of perfluorocarbon previously injected into the preretinal vitreous. • Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the first time studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days I and 3 after cell injection, retinal detachment. • Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development of reretinal neovascularization in the fibroblast-injected rabbit eye.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Handa, James T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Berkowitz, Bruce A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wilson, Charles A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ando, Noburo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sen, Harsha A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jaffe, Glenn J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Graefe's archive for clinical and experimental ophthalmology</subfield><subfield code="d">1854</subfield><subfield code="g">234(1996) vom: Jan., Seite 43-46</subfield><subfield code="w">(DE-627)NLEJ188993738</subfield><subfield code="w">(DE-600)1459159-5</subfield><subfield code="x">1435-702X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:234</subfield><subfield code="g">year:1996</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:43-46</subfield><subfield code="g">extent:4</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00186517</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">234</subfield><subfield code="j">1996</subfield><subfield code="c">1</subfield><subfield code="h">43-46</subfield><subfield code="g">4</subfield></datafield></record></collection>
|
| score |
7.398508 |