Hypoxic ventilatory response during rest and exercise after a Himalayan expedition
Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were expo...
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Englisch |
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1996 |
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8 |
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Springer Online Journal Archives 1860-2002 |
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in: European journal of applied physiology - 1928, 73(1996) vom: März/Apr., Seite 202-209 |
Übergeordnetes Werk: |
volume:73 ; year:1996 ; month:03/04 ; pages:202-209 ; extent:8 |
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NLEJ204521769 |
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520 | |a Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. The augmentation of HVR was evident at higher exercise intensities and we suggest that this reflects a change in sensitivity of the peripheral chemoreflex loop. | ||
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(DE-627)NLEJ204521769 DE-627 ger DE-627 rakwb eng Hypoxic ventilatory response during rest and exercise after a Himalayan expedition 1996 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. The augmentation of HVR was evident at higher exercise intensities and we suggest that this reflects a change in sensitivity of the peripheral chemoreflex loop. Springer Online Journal Archives 1860-2002 Steinacker, J. M. oth Halder, A. oth Liu, Y. oth Thomas, A. oth Stauch, M. oth in European journal of applied physiology 1928 73(1996) vom: März/Apr., Seite 202-209 (DE-627)NLEJ188991794 (DE-600)1459054-2 1439-6327 nnns volume:73 year:1996 month:03/04 pages:202-209 extent:8 http://dx.doi.org/10.1007/BF02425477 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 73 1996 3/4 202-209 8 |
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(DE-627)NLEJ204521769 DE-627 ger DE-627 rakwb eng Hypoxic ventilatory response during rest and exercise after a Himalayan expedition 1996 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. The augmentation of HVR was evident at higher exercise intensities and we suggest that this reflects a change in sensitivity of the peripheral chemoreflex loop. Springer Online Journal Archives 1860-2002 Steinacker, J. M. oth Halder, A. oth Liu, Y. oth Thomas, A. oth Stauch, M. oth in European journal of applied physiology 1928 73(1996) vom: März/Apr., Seite 202-209 (DE-627)NLEJ188991794 (DE-600)1459054-2 1439-6327 nnns volume:73 year:1996 month:03/04 pages:202-209 extent:8 http://dx.doi.org/10.1007/BF02425477 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 73 1996 3/4 202-209 8 |
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(DE-627)NLEJ204521769 DE-627 ger DE-627 rakwb eng Hypoxic ventilatory response during rest and exercise after a Himalayan expedition 1996 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. The augmentation of HVR was evident at higher exercise intensities and we suggest that this reflects a change in sensitivity of the peripheral chemoreflex loop. Springer Online Journal Archives 1860-2002 Steinacker, J. M. oth Halder, A. oth Liu, Y. oth Thomas, A. oth Stauch, M. oth in European journal of applied physiology 1928 73(1996) vom: März/Apr., Seite 202-209 (DE-627)NLEJ188991794 (DE-600)1459054-2 1439-6327 nnns volume:73 year:1996 month:03/04 pages:202-209 extent:8 http://dx.doi.org/10.1007/BF02425477 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 73 1996 3/4 202-209 8 |
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(DE-627)NLEJ204521769 DE-627 ger DE-627 rakwb eng Hypoxic ventilatory response during rest and exercise after a Himalayan expedition 1996 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. The augmentation of HVR was evident at higher exercise intensities and we suggest that this reflects a change in sensitivity of the peripheral chemoreflex loop. Springer Online Journal Archives 1860-2002 Steinacker, J. M. oth Halder, A. oth Liu, Y. oth Thomas, A. oth Stauch, M. oth in European journal of applied physiology 1928 73(1996) vom: März/Apr., Seite 202-209 (DE-627)NLEJ188991794 (DE-600)1459054-2 1439-6327 nnns volume:73 year:1996 month:03/04 pages:202-209 extent:8 http://dx.doi.org/10.1007/BF02425477 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 73 1996 3/4 202-209 8 |
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(DE-627)NLEJ204521769 DE-627 ger DE-627 rakwb eng Hypoxic ventilatory response during rest and exercise after a Himalayan expedition 1996 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. The augmentation of HVR was evident at higher exercise intensities and we suggest that this reflects a change in sensitivity of the peripheral chemoreflex loop. Springer Online Journal Archives 1860-2002 Steinacker, J. M. oth Halder, A. oth Liu, Y. oth Thomas, A. oth Stauch, M. oth in European journal of applied physiology 1928 73(1996) vom: März/Apr., Seite 202-209 (DE-627)NLEJ188991794 (DE-600)1459054-2 1439-6327 nnns volume:73 year:1996 month:03/04 pages:202-209 extent:8 http://dx.doi.org/10.1007/BF02425477 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 73 1996 3/4 202-209 8 |
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Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. 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hypoxic ventilatory response during rest and exercise after a himalayan expedition |
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Hypoxic ventilatory response during rest and exercise after a Himalayan expedition |
abstract |
Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. The augmentation of HVR was evident at higher exercise intensities and we suggest that this reflects a change in sensitivity of the peripheral chemoreflex loop. |
abstractGer |
Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. The augmentation of HVR was evident at higher exercise intensities and we suggest that this reflects a change in sensitivity of the peripheral chemoreflex loop. |
abstract_unstemmed |
Abstract Hypoxic ventilatory response (HVR) was examined before and after acclimatization to high altitude. Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. The augmentation of HVR was evident at higher exercise intensities and we suggest that this reflects a change in sensitivity of the peripheral chemoreflex loop. |
collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
title_short |
Hypoxic ventilatory response during rest and exercise after a Himalayan expedition |
url |
http://dx.doi.org/10.1007/BF02425477 |
remote_bool |
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author2 |
Steinacker, J. M. Halder, A. Liu, Y. Thomas, A. Stauch, M. |
author2Str |
Steinacker, J. M. Halder, A. Liu, Y. Thomas, A. Stauch, M. |
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NLEJ188991794 |
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up_date |
2024-07-06T00:59:21.855Z |
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Transient hyperoxic switches according to Dejours's technique were used to examine the contribution of HVR to the hyperpnoea of increasing exercise intensities. Ten mountaineers were exposed to hypoxia (oxygen fraction in inspired gas,F 1O2 = 0.11, 79 mmHg) before the expedition and after return from altitude (56 days, 30 days at 4900 m or higher). After 25-min breathing hypoxic gas, the subjects performed a maximal cycle ergometer test (increments 50 W per 5 min). Respired gases and ventilation $$(\dot V_E )$$ were analysed breath-by-breath, partial pressure of oxygen (PO2) and oxygen saturation (SO2) were measured in capillary blood. The HVR was tested by switching two breaths to anF 1O2 of 1.0. The nadir of $$\dot V_E $$ after the switch was measured (decrease in ventilation, D $$\dot V_E $$ ). The HVR was expressed as the D $$\dot V_E $$ at a PO2 of 40 mmHg (D $$\dot V_{E40} $$ ) and the D $$\dot V_E $$ versus decrease ofSO2 (D $$\dot V_E $$ /[100 −SO2]). The HVR estimated by D $$\dot V_{E40} $$ increased from 19.9 to 28.01 · min−1 (median,P = 0.013). The HVR expressed as D $$\dot V_E $$ /(100 −SO2) at rest was no different before and after acclimatization (0.89 and 0.86 l · min−1 · %−1, respectively) and during exercise it did not change before the expedition (0.831 · min−1 %−1). However, D $$\dot V_E $$ /(100 −SO2) increased significantly with exercise intensity after the expedition (1.61 l · min−1 · %−1 at 200 W). The changes of D $$\dot V_E $$ versusSO2 as well as of D $$\dot V_E $$ versus $$\dot V_E $$ were steeper after the expedition than before. In summary, after return from 30 day at high altitude, an increased HVR was observed. 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