β-Catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome
Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (AP...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2000 |
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| Umfang: |
6 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Virchows Archiv - 1847, 437(2000) vom: Juni, Seite 599-604 |
| Übergeordnetes Werk: |
volume:437 ; year:2000 ; month:06 ; pages:599-604 ; extent:6 |
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| 245 | 1 | 0 | |a β-Catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome |
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| 520 | |a Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the β-catenin gene, can activate this important pathway in the development of several carcinomas. To determine whether this pathway for malignant transformation is important in oesophageal cancer, we analysed 39 primary oesophageal squamous cell carcinomas (OSCC). Immunohistochemical expression of β-catenin was studied in formalin-fixed, paraffin-embedded tissue samples. Results were correlated with clinicopathological parameters and immunohistochemical expression of the proteins p53, E-cadherin, bcl-2 and Ki-67. All examined OSCC had β-catenin expression localised in the cellular membrane, frequently with a heterogeneous pattern. Seven (18%) cases also showed immunoexpression in the cytoplasm and nuclei of the tumour cells. These seven tumours were localised in the upper (three) or in the middle third (four) of the oesophagus. Only one patient had p53 expression and all had bcl-2 expression. The consensus sequence for glycogen synthase kinase (GSK) 3β phosphorylation in exon 3 of the β-catenin gene was studied using polymerase chain reaction and direct sequencing in the seven cases with nuclear β-catenin expression. No genetic alteration was found. These results suggest that β-catenin expression may characterise a subset of OSCC. | ||
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| 700 | 1 | |a Moreno-Bueno, Gema |4 oth | |
| 700 | 1 | |a Rodríguez, N. |4 oth | |
| 700 | 1 | |a Feliu, J. |4 oth | |
| 700 | 1 | |a González-Barón, M. |4 oth | |
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(DE-627)NLEJ205002285 DE-627 ger DE-627 rakwb eng β-Catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the β-catenin gene, can activate this important pathway in the development of several carcinomas. To determine whether this pathway for malignant transformation is important in oesophageal cancer, we analysed 39 primary oesophageal squamous cell carcinomas (OSCC). Immunohistochemical expression of β-catenin was studied in formalin-fixed, paraffin-embedded tissue samples. Results were correlated with clinicopathological parameters and immunohistochemical expression of the proteins p53, E-cadherin, bcl-2 and Ki-67. All examined OSCC had β-catenin expression localised in the cellular membrane, frequently with a heterogeneous pattern. Seven (18%) cases also showed immunoexpression in the cytoplasm and nuclei of the tumour cells. These seven tumours were localised in the upper (three) or in the middle third (four) of the oesophagus. Only one patient had p53 expression and all had bcl-2 expression. The consensus sequence for glycogen synthase kinase (GSK) 3β phosphorylation in exon 3 of the β-catenin gene was studied using polymerase chain reaction and direct sequencing in the seven cases with nuclear β-catenin expression. No genetic alteration was found. These results suggest that β-catenin expression may characterise a subset of OSCC. Springer Online Journal Archives 1860-2002 de Castro, Javier oth Gamallo, Carlos oth Palacios, José oth Moreno-Bueno, Gema oth Rodríguez, N. oth Feliu, J. oth González-Barón, M. oth in Virchows Archiv 1847 437(2000) vom: Juni, Seite 599-604 (DE-627)NLEJ188987746 (DE-600)1463276-7 1432-2307 nnns volume:437 year:2000 month:06 pages:599-604 extent:6 http://dx.doi.org/10.1007/s004280000266 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 437 2000 6 599-604 6 |
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(DE-627)NLEJ205002285 DE-627 ger DE-627 rakwb eng β-Catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the β-catenin gene, can activate this important pathway in the development of several carcinomas. To determine whether this pathway for malignant transformation is important in oesophageal cancer, we analysed 39 primary oesophageal squamous cell carcinomas (OSCC). Immunohistochemical expression of β-catenin was studied in formalin-fixed, paraffin-embedded tissue samples. Results were correlated with clinicopathological parameters and immunohistochemical expression of the proteins p53, E-cadherin, bcl-2 and Ki-67. All examined OSCC had β-catenin expression localised in the cellular membrane, frequently with a heterogeneous pattern. Seven (18%) cases also showed immunoexpression in the cytoplasm and nuclei of the tumour cells. These seven tumours were localised in the upper (three) or in the middle third (four) of the oesophagus. Only one patient had p53 expression and all had bcl-2 expression. The consensus sequence for glycogen synthase kinase (GSK) 3β phosphorylation in exon 3 of the β-catenin gene was studied using polymerase chain reaction and direct sequencing in the seven cases with nuclear β-catenin expression. No genetic alteration was found. These results suggest that β-catenin expression may characterise a subset of OSCC. Springer Online Journal Archives 1860-2002 de Castro, Javier oth Gamallo, Carlos oth Palacios, José oth Moreno-Bueno, Gema oth Rodríguez, N. oth Feliu, J. oth González-Barón, M. oth in Virchows Archiv 1847 437(2000) vom: Juni, Seite 599-604 (DE-627)NLEJ188987746 (DE-600)1463276-7 1432-2307 nnns volume:437 year:2000 month:06 pages:599-604 extent:6 http://dx.doi.org/10.1007/s004280000266 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 437 2000 6 599-604 6 |
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(DE-627)NLEJ205002285 DE-627 ger DE-627 rakwb eng β-Catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the β-catenin gene, can activate this important pathway in the development of several carcinomas. To determine whether this pathway for malignant transformation is important in oesophageal cancer, we analysed 39 primary oesophageal squamous cell carcinomas (OSCC). Immunohistochemical expression of β-catenin was studied in formalin-fixed, paraffin-embedded tissue samples. Results were correlated with clinicopathological parameters and immunohistochemical expression of the proteins p53, E-cadherin, bcl-2 and Ki-67. All examined OSCC had β-catenin expression localised in the cellular membrane, frequently with a heterogeneous pattern. Seven (18%) cases also showed immunoexpression in the cytoplasm and nuclei of the tumour cells. These seven tumours were localised in the upper (three) or in the middle third (four) of the oesophagus. Only one patient had p53 expression and all had bcl-2 expression. The consensus sequence for glycogen synthase kinase (GSK) 3β phosphorylation in exon 3 of the β-catenin gene was studied using polymerase chain reaction and direct sequencing in the seven cases with nuclear β-catenin expression. No genetic alteration was found. These results suggest that β-catenin expression may characterise a subset of OSCC. Springer Online Journal Archives 1860-2002 de Castro, Javier oth Gamallo, Carlos oth Palacios, José oth Moreno-Bueno, Gema oth Rodríguez, N. oth Feliu, J. oth González-Barón, M. oth in Virchows Archiv 1847 437(2000) vom: Juni, Seite 599-604 (DE-627)NLEJ188987746 (DE-600)1463276-7 1432-2307 nnns volume:437 year:2000 month:06 pages:599-604 extent:6 http://dx.doi.org/10.1007/s004280000266 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 437 2000 6 599-604 6 |
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(DE-627)NLEJ205002285 DE-627 ger DE-627 rakwb eng β-Catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the β-catenin gene, can activate this important pathway in the development of several carcinomas. To determine whether this pathway for malignant transformation is important in oesophageal cancer, we analysed 39 primary oesophageal squamous cell carcinomas (OSCC). Immunohistochemical expression of β-catenin was studied in formalin-fixed, paraffin-embedded tissue samples. Results were correlated with clinicopathological parameters and immunohistochemical expression of the proteins p53, E-cadherin, bcl-2 and Ki-67. All examined OSCC had β-catenin expression localised in the cellular membrane, frequently with a heterogeneous pattern. Seven (18%) cases also showed immunoexpression in the cytoplasm and nuclei of the tumour cells. These seven tumours were localised in the upper (three) or in the middle third (four) of the oesophagus. Only one patient had p53 expression and all had bcl-2 expression. The consensus sequence for glycogen synthase kinase (GSK) 3β phosphorylation in exon 3 of the β-catenin gene was studied using polymerase chain reaction and direct sequencing in the seven cases with nuclear β-catenin expression. No genetic alteration was found. These results suggest that β-catenin expression may characterise a subset of OSCC. Springer Online Journal Archives 1860-2002 de Castro, Javier oth Gamallo, Carlos oth Palacios, José oth Moreno-Bueno, Gema oth Rodríguez, N. oth Feliu, J. oth González-Barón, M. oth in Virchows Archiv 1847 437(2000) vom: Juni, Seite 599-604 (DE-627)NLEJ188987746 (DE-600)1463276-7 1432-2307 nnns volume:437 year:2000 month:06 pages:599-604 extent:6 http://dx.doi.org/10.1007/s004280000266 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 437 2000 6 599-604 6 |
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(DE-627)NLEJ205002285 DE-627 ger DE-627 rakwb eng β-Catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the β-catenin gene, can activate this important pathway in the development of several carcinomas. To determine whether this pathway for malignant transformation is important in oesophageal cancer, we analysed 39 primary oesophageal squamous cell carcinomas (OSCC). Immunohistochemical expression of β-catenin was studied in formalin-fixed, paraffin-embedded tissue samples. Results were correlated with clinicopathological parameters and immunohistochemical expression of the proteins p53, E-cadherin, bcl-2 and Ki-67. All examined OSCC had β-catenin expression localised in the cellular membrane, frequently with a heterogeneous pattern. Seven (18%) cases also showed immunoexpression in the cytoplasm and nuclei of the tumour cells. These seven tumours were localised in the upper (three) or in the middle third (four) of the oesophagus. Only one patient had p53 expression and all had bcl-2 expression. The consensus sequence for glycogen synthase kinase (GSK) 3β phosphorylation in exon 3 of the β-catenin gene was studied using polymerase chain reaction and direct sequencing in the seven cases with nuclear β-catenin expression. No genetic alteration was found. These results suggest that β-catenin expression may characterise a subset of OSCC. Springer Online Journal Archives 1860-2002 de Castro, Javier oth Gamallo, Carlos oth Palacios, José oth Moreno-Bueno, Gema oth Rodríguez, N. oth Feliu, J. oth González-Barón, M. oth in Virchows Archiv 1847 437(2000) vom: Juni, Seite 599-604 (DE-627)NLEJ188987746 (DE-600)1463276-7 1432-2307 nnns volume:437 year:2000 month:06 pages:599-604 extent:6 http://dx.doi.org/10.1007/s004280000266 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 437 2000 6 599-604 6 |
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β-Catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome |
| abstract |
Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the β-catenin gene, can activate this important pathway in the development of several carcinomas. To determine whether this pathway for malignant transformation is important in oesophageal cancer, we analysed 39 primary oesophageal squamous cell carcinomas (OSCC). Immunohistochemical expression of β-catenin was studied in formalin-fixed, paraffin-embedded tissue samples. Results were correlated with clinicopathological parameters and immunohistochemical expression of the proteins p53, E-cadherin, bcl-2 and Ki-67. All examined OSCC had β-catenin expression localised in the cellular membrane, frequently with a heterogeneous pattern. Seven (18%) cases also showed immunoexpression in the cytoplasm and nuclei of the tumour cells. These seven tumours were localised in the upper (three) or in the middle third (four) of the oesophagus. Only one patient had p53 expression and all had bcl-2 expression. The consensus sequence for glycogen synthase kinase (GSK) 3β phosphorylation in exon 3 of the β-catenin gene was studied using polymerase chain reaction and direct sequencing in the seven cases with nuclear β-catenin expression. No genetic alteration was found. These results suggest that β-catenin expression may characterise a subset of OSCC. |
| abstractGer |
Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the β-catenin gene, can activate this important pathway in the development of several carcinomas. To determine whether this pathway for malignant transformation is important in oesophageal cancer, we analysed 39 primary oesophageal squamous cell carcinomas (OSCC). Immunohistochemical expression of β-catenin was studied in formalin-fixed, paraffin-embedded tissue samples. Results were correlated with clinicopathological parameters and immunohistochemical expression of the proteins p53, E-cadherin, bcl-2 and Ki-67. All examined OSCC had β-catenin expression localised in the cellular membrane, frequently with a heterogeneous pattern. Seven (18%) cases also showed immunoexpression in the cytoplasm and nuclei of the tumour cells. These seven tumours were localised in the upper (three) or in the middle third (four) of the oesophagus. Only one patient had p53 expression and all had bcl-2 expression. The consensus sequence for glycogen synthase kinase (GSK) 3β phosphorylation in exon 3 of the β-catenin gene was studied using polymerase chain reaction and direct sequencing in the seven cases with nuclear β-catenin expression. No genetic alteration was found. These results suggest that β-catenin expression may characterise a subset of OSCC. |
| abstract_unstemmed |
Abstract. β-Catenin has an essential role in intercellular adhesion and signal transduction. β-catenin functions as a transcriptional activator downstream in the Wnt signalling pathway. Cytoplasmic stabilisation of β-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the β-catenin gene, can activate this important pathway in the development of several carcinomas. To determine whether this pathway for malignant transformation is important in oesophageal cancer, we analysed 39 primary oesophageal squamous cell carcinomas (OSCC). Immunohistochemical expression of β-catenin was studied in formalin-fixed, paraffin-embedded tissue samples. Results were correlated with clinicopathological parameters and immunohistochemical expression of the proteins p53, E-cadherin, bcl-2 and Ki-67. All examined OSCC had β-catenin expression localised in the cellular membrane, frequently with a heterogeneous pattern. Seven (18%) cases also showed immunoexpression in the cytoplasm and nuclei of the tumour cells. These seven tumours were localised in the upper (three) or in the middle third (four) of the oesophagus. Only one patient had p53 expression and all had bcl-2 expression. The consensus sequence for glycogen synthase kinase (GSK) 3β phosphorylation in exon 3 of the β-catenin gene was studied using polymerase chain reaction and direct sequencing in the seven cases with nuclear β-catenin expression. No genetic alteration was found. These results suggest that β-catenin expression may characterise a subset of OSCC. |
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β-Catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome |
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http://dx.doi.org/10.1007/s004280000266 |
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de Castro, Javier Gamallo, Carlos Palacios, José Moreno-Bueno, Gema Rodríguez, N. Feliu, J. González-Barón, M. |
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de Castro, Javier Gamallo, Carlos Palacios, José Moreno-Bueno, Gema Rodríguez, N. Feliu, J. González-Barón, M. |
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