Erythrocytes as carriers for heparin
Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1986 |
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| Umfang: |
6 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Research in experimental medicine - 1913, 186(1986) vom: Juni, Seite 407-412 |
| Übergeordnetes Werk: |
volume:186 ; year:1986 ; month:06 ; pages:407-412 ; extent:6 |
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NLEJ205356923 |
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| 520 | |a Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and 36% encapsulation, respectively. Encapsulated heparin did not leak from carrier erythrocytes in vitro. In vivo survival of heparin-loaded carrier erythrocytes in dogs was biphasic: After an initial phase of cell loss the carrier cells survived in circulation with a half-life of 28 h. The present results seem to warrant clinical studies with heparin-loaded carrier erythrocytes. | ||
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| 700 | 1 | |a Eichler, H. G. |4 oth | |
| 700 | 1 | |a Schneider, W. |4 oth | |
| 700 | 1 | |a Raberger, G. |4 oth | |
| 700 | 1 | |a Bacher, S. |4 oth | |
| 700 | 1 | |a Pabinger, I. |4 oth | |
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(DE-627)NLEJ205356923 DE-627 ger DE-627 rakwb eng Erythrocytes as carriers for heparin 1986 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and 36% encapsulation, respectively. Encapsulated heparin did not leak from carrier erythrocytes in vitro. In vivo survival of heparin-loaded carrier erythrocytes in dogs was biphasic: After an initial phase of cell loss the carrier cells survived in circulation with a half-life of 28 h. The present results seem to warrant clinical studies with heparin-loaded carrier erythrocytes. Springer Online Journal Archives 1860-2002 Eichler, H. G. oth Schneider, W. oth Raberger, G. oth Bacher, S. oth Pabinger, I. oth in Research in experimental medicine 1913 186(1986) vom: Juni, Seite 407-412 (DE-627)NLEJ188984933 (DE-600)1463038-2 1433-8580 nnns volume:186 year:1986 month:06 pages:407-412 extent:6 http://dx.doi.org/10.1007/BF01852193 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 186 1986 6 407-412 6 |
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(DE-627)NLEJ205356923 DE-627 ger DE-627 rakwb eng Erythrocytes as carriers for heparin 1986 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and 36% encapsulation, respectively. Encapsulated heparin did not leak from carrier erythrocytes in vitro. In vivo survival of heparin-loaded carrier erythrocytes in dogs was biphasic: After an initial phase of cell loss the carrier cells survived in circulation with a half-life of 28 h. The present results seem to warrant clinical studies with heparin-loaded carrier erythrocytes. Springer Online Journal Archives 1860-2002 Eichler, H. G. oth Schneider, W. oth Raberger, G. oth Bacher, S. oth Pabinger, I. oth in Research in experimental medicine 1913 186(1986) vom: Juni, Seite 407-412 (DE-627)NLEJ188984933 (DE-600)1463038-2 1433-8580 nnns volume:186 year:1986 month:06 pages:407-412 extent:6 http://dx.doi.org/10.1007/BF01852193 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 186 1986 6 407-412 6 |
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(DE-627)NLEJ205356923 DE-627 ger DE-627 rakwb eng Erythrocytes as carriers for heparin 1986 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and 36% encapsulation, respectively. Encapsulated heparin did not leak from carrier erythrocytes in vitro. In vivo survival of heparin-loaded carrier erythrocytes in dogs was biphasic: After an initial phase of cell loss the carrier cells survived in circulation with a half-life of 28 h. The present results seem to warrant clinical studies with heparin-loaded carrier erythrocytes. Springer Online Journal Archives 1860-2002 Eichler, H. G. oth Schneider, W. oth Raberger, G. oth Bacher, S. oth Pabinger, I. oth in Research in experimental medicine 1913 186(1986) vom: Juni, Seite 407-412 (DE-627)NLEJ188984933 (DE-600)1463038-2 1433-8580 nnns volume:186 year:1986 month:06 pages:407-412 extent:6 http://dx.doi.org/10.1007/BF01852193 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 186 1986 6 407-412 6 |
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(DE-627)NLEJ205356923 DE-627 ger DE-627 rakwb eng Erythrocytes as carriers for heparin 1986 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and 36% encapsulation, respectively. Encapsulated heparin did not leak from carrier erythrocytes in vitro. In vivo survival of heparin-loaded carrier erythrocytes in dogs was biphasic: After an initial phase of cell loss the carrier cells survived in circulation with a half-life of 28 h. The present results seem to warrant clinical studies with heparin-loaded carrier erythrocytes. Springer Online Journal Archives 1860-2002 Eichler, H. G. oth Schneider, W. oth Raberger, G. oth Bacher, S. oth Pabinger, I. oth in Research in experimental medicine 1913 186(1986) vom: Juni, Seite 407-412 (DE-627)NLEJ188984933 (DE-600)1463038-2 1433-8580 nnns volume:186 year:1986 month:06 pages:407-412 extent:6 http://dx.doi.org/10.1007/BF01852193 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 186 1986 6 407-412 6 |
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(DE-627)NLEJ205356923 DE-627 ger DE-627 rakwb eng Erythrocytes as carriers for heparin 1986 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and 36% encapsulation, respectively. Encapsulated heparin did not leak from carrier erythrocytes in vitro. In vivo survival of heparin-loaded carrier erythrocytes in dogs was biphasic: After an initial phase of cell loss the carrier cells survived in circulation with a half-life of 28 h. The present results seem to warrant clinical studies with heparin-loaded carrier erythrocytes. Springer Online Journal Archives 1860-2002 Eichler, H. G. oth Schneider, W. oth Raberger, G. oth Bacher, S. oth Pabinger, I. oth in Research in experimental medicine 1913 186(1986) vom: Juni, Seite 407-412 (DE-627)NLEJ188984933 (DE-600)1463038-2 1433-8580 nnns volume:186 year:1986 month:06 pages:407-412 extent:6 http://dx.doi.org/10.1007/BF01852193 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 186 1986 6 407-412 6 |
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Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and 36% encapsulation, respectively. Encapsulated heparin did not leak from carrier erythrocytes in vitro. In vivo survival of heparin-loaded carrier erythrocytes in dogs was biphasic: After an initial phase of cell loss the carrier cells survived in circulation with a half-life of 28 h. The present results seem to warrant clinical studies with heparin-loaded carrier erythrocytes. |
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Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and 36% encapsulation, respectively. Encapsulated heparin did not leak from carrier erythrocytes in vitro. In vivo survival of heparin-loaded carrier erythrocytes in dogs was biphasic: After an initial phase of cell loss the carrier cells survived in circulation with a half-life of 28 h. The present results seem to warrant clinical studies with heparin-loaded carrier erythrocytes. |
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Summary Encapsulation of heparin into resealed carrier erythrocytes may be useful in the prevention of thromboembolism because heparin may be released locally during retraction of fresh thrombi. Heparin encapsulation in human and canine erythrocytes was achieved by hypo-osmotic dialysis with 44% and 36% encapsulation, respectively. Encapsulated heparin did not leak from carrier erythrocytes in vitro. In vivo survival of heparin-loaded carrier erythrocytes in dogs was biphasic: After an initial phase of cell loss the carrier cells survived in circulation with a half-life of 28 h. The present results seem to warrant clinical studies with heparin-loaded carrier erythrocytes. |
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