Mathematical modelling of haemodialysis in children
Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Chi...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1992 |
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| Umfang: |
5 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Pediatric nephrology - 1987, 6(1992) vom: Apr., Seite 349-353 |
| Übergeordnetes Werk: |
volume:6 ; year:1992 ; month:04 ; pages:349-353 ; extent:5 |
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| 520 | |a Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V. | ||
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(DE-627)NLEJ205957730 DE-627 ger DE-627 rakwb eng Mathematical modelling of haemodialysis in children 1992 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V. Springer Online Journal Archives 1860-2002 Evans, Jonathan H. C. oth Smye, Stephen W. oth Brocklebank, J. Trevor oth in Pediatric nephrology 1987 6(1992) vom: Apr., Seite 349-353 (DE-627)NLEJ188983775 (DE-600)1463004-7 1432-198X nnns volume:6 year:1992 month:04 pages:349-353 extent:5 http://dx.doi.org/10.1007/BF00869732 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1992 4 349-353 5 |
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(DE-627)NLEJ205957730 DE-627 ger DE-627 rakwb eng Mathematical modelling of haemodialysis in children 1992 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V. Springer Online Journal Archives 1860-2002 Evans, Jonathan H. C. oth Smye, Stephen W. oth Brocklebank, J. Trevor oth in Pediatric nephrology 1987 6(1992) vom: Apr., Seite 349-353 (DE-627)NLEJ188983775 (DE-600)1463004-7 1432-198X nnns volume:6 year:1992 month:04 pages:349-353 extent:5 http://dx.doi.org/10.1007/BF00869732 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1992 4 349-353 5 |
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(DE-627)NLEJ205957730 DE-627 ger DE-627 rakwb eng Mathematical modelling of haemodialysis in children 1992 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V. Springer Online Journal Archives 1860-2002 Evans, Jonathan H. C. oth Smye, Stephen W. oth Brocklebank, J. Trevor oth in Pediatric nephrology 1987 6(1992) vom: Apr., Seite 349-353 (DE-627)NLEJ188983775 (DE-600)1463004-7 1432-198X nnns volume:6 year:1992 month:04 pages:349-353 extent:5 http://dx.doi.org/10.1007/BF00869732 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1992 4 349-353 5 |
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(DE-627)NLEJ205957730 DE-627 ger DE-627 rakwb eng Mathematical modelling of haemodialysis in children 1992 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V. Springer Online Journal Archives 1860-2002 Evans, Jonathan H. C. oth Smye, Stephen W. oth Brocklebank, J. Trevor oth in Pediatric nephrology 1987 6(1992) vom: Apr., Seite 349-353 (DE-627)NLEJ188983775 (DE-600)1463004-7 1432-198X nnns volume:6 year:1992 month:04 pages:349-353 extent:5 http://dx.doi.org/10.1007/BF00869732 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1992 4 349-353 5 |
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(DE-627)NLEJ205957730 DE-627 ger DE-627 rakwb eng Mathematical modelling of haemodialysis in children 1992 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V. Springer Online Journal Archives 1860-2002 Evans, Jonathan H. C. oth Smye, Stephen W. oth Brocklebank, J. Trevor oth in Pediatric nephrology 1987 6(1992) vom: Apr., Seite 349-353 (DE-627)NLEJ188983775 (DE-600)1463004-7 1432-198X nnns volume:6 year:1992 month:04 pages:349-353 extent:5 http://dx.doi.org/10.1007/BF00869732 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1992 4 349-353 5 |
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Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V. |
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Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V. |
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Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ205957730</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706190836.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1992 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ205957730</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Mathematical modelling of haemodialysis in children</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1992</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">5</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The single-pool urea kinetic model (UKM), utilising “Kt/V” (the normalised whole body urea clearance), is widely used to help assess the adequacy of haemodialysis in adults. In the presence of an adequate dietary protein intake, a value of unity is acceptable for thrice weekly dialysis. Children could benefit from this approach but, with their relatively higher protein intakes and dialysis needs, this model may not be applicable. Urea kinetics, studied in six children with chronic renal failure by serial timed blood urea measurements during and after haemodialysis, were compared with the kinetics of a one-pool and a two-pool UKM. The two-pool UKM with intra- and extracellular pools best fitted the observed data, re-equilibration between pools accounting for the marked rebound increase in blood urea seen in the 1 st h after dialysis (μ 17%, SD 5). Kt/V calculated using the end-dialysis blood urea was higher (μ 21%, SD 5) than when the more correct equilibrated value was used. The post-dialysis rebound indicates significant disequilibrium between the two pools at the end of dialysis. Dialysis efficiency may be substantially overestimated unless this is allowed for by using the rebounded post-dialysis blood urea when calculating Kt/V.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Evans, Jonathan H. C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Smye, Stephen W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brocklebank, J. Trevor</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Pediatric nephrology</subfield><subfield code="d">1987</subfield><subfield code="g">6(1992) vom: Apr., Seite 349-353</subfield><subfield code="w">(DE-627)NLEJ188983775</subfield><subfield code="w">(DE-600)1463004-7</subfield><subfield code="x">1432-198X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:6</subfield><subfield code="g">year:1992</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:349-353</subfield><subfield code="g">extent:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00869732</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">6</subfield><subfield code="j">1992</subfield><subfield code="c">4</subfield><subfield code="h">349-353</subfield><subfield code="g">5</subfield></datafield></record></collection>
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