Influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: II. A theoretical model
Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, a...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1976 |
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| Umfang: |
19 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: The journal of membrane biology - 1969, 30(1976) vom: Jan., Seite 45-63 |
| Übergeordnetes Werk: |
volume:30 ; year:1976 ; month:01 ; pages:45-63 ; extent:19 |
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| 245 | 1 | 0 | |a Influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: II. A theoretical model |
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| 520 | |a Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements. | ||
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(DE-627)NLEJ207060312 DE-627 ger DE-627 rakwb eng Influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: II. A theoretical model 1976 19 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements. Springer Online Journal Archives 1860-2002 Ciani, S. oth in The journal of membrane biology 1969 30(1976) vom: Jan., Seite 45-63 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:30 year:1976 month:01 pages:45-63 extent:19 http://dx.doi.org/10.1007/BF01869659 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1976 1 45-63 19 |
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(DE-627)NLEJ207060312 DE-627 ger DE-627 rakwb eng Influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: II. A theoretical model 1976 19 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements. Springer Online Journal Archives 1860-2002 Ciani, S. oth in The journal of membrane biology 1969 30(1976) vom: Jan., Seite 45-63 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:30 year:1976 month:01 pages:45-63 extent:19 http://dx.doi.org/10.1007/BF01869659 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1976 1 45-63 19 |
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(DE-627)NLEJ207060312 DE-627 ger DE-627 rakwb eng Influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: II. A theoretical model 1976 19 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements. Springer Online Journal Archives 1860-2002 Ciani, S. oth in The journal of membrane biology 1969 30(1976) vom: Jan., Seite 45-63 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:30 year:1976 month:01 pages:45-63 extent:19 http://dx.doi.org/10.1007/BF01869659 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1976 1 45-63 19 |
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(DE-627)NLEJ207060312 DE-627 ger DE-627 rakwb eng Influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: II. A theoretical model 1976 19 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements. Springer Online Journal Archives 1860-2002 Ciani, S. oth in The journal of membrane biology 1969 30(1976) vom: Jan., Seite 45-63 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:30 year:1976 month:01 pages:45-63 extent:19 http://dx.doi.org/10.1007/BF01869659 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1976 1 45-63 19 |
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(DE-627)NLEJ207060312 DE-627 ger DE-627 rakwb eng Influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: II. A theoretical model 1976 19 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements. Springer Online Journal Archives 1860-2002 Ciani, S. oth in The journal of membrane biology 1969 30(1976) vom: Jan., Seite 45-63 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:30 year:1976 month:01 pages:45-63 extent:19 http://dx.doi.org/10.1007/BF01869659 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1976 1 45-63 19 |
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influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: ii. a theoretical model |
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Influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: II. A theoretical model |
| abstract |
Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements. |
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Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements. |
| abstract_unstemmed |
Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ207060312</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706220350.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1976 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ207060312</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Influence of molecular variations of ionophore and lipid on the selective ion permeability of membranes: II. A theoretical model</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1976</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">19</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary The steady-state electrical properties induced by neutral carriers of ions in lipid bilayer membranes and the time dependence of the membrane current for low applied voltages are described theoretically in terms of a model which allows for a voltage dependence of the interfacial reactions, as well as for a trapezoidal shape of the internal free energy barrier for translocation of the complex. The basic features of the model are closely related to those of others presented previously (J.E. Hall, C.A. Mead & G. Szabo, 1973,J. Membrane Biol. 11:75; S.B. Hladky, 1974,Biochim. Biophys. Acta 352:71; S.B. Hladky, 1975,Biochim. Biophys. Acta 375:327; Eisenman, Krasne & Ciani, 1975,Ann. N.Y. Acad. Sci. 264:34), but the analysis of its consequences on the steady-state and nonsteady-state electrical characteristics is given here in greater detail and is extended to provide the expression for the zero-current potential in ionic gradients. It is shown that parameters, such as the width of the trapezoidal barrier, the plane of the reaction and the ratio of the rate constant of translocation across the membrane interior to the rate constant of dissociation of the complex, can be deduced from steady-state analysis, whereas the individual values of these constants and the distance between the equilibrium positions of the complexes are deducible from relaxation measurements.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ciani, S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">The journal of membrane biology</subfield><subfield code="d">1969</subfield><subfield code="g">30(1976) vom: Jan., Seite 45-63</subfield><subfield code="w">(DE-627)NLEJ18899419X</subfield><subfield code="w">(DE-600)1459323-3</subfield><subfield code="x">1432-1424</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:30</subfield><subfield code="g">year:1976</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:45-63</subfield><subfield code="g">extent:19</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01869659</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">30</subfield><subfield code="j">1976</subfield><subfield code="c">1</subfield><subfield code="h">45-63</subfield><subfield code="g">19</subfield></datafield></record></collection>
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