Competitive membrane adsorption of Na+, K+, and Ca2+ in smooth muscle cells
Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk so...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1981 |
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| Umfang: |
7 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: The journal of membrane biology - 1969, 58(1981) vom: Feb., Seite 115-121 |
| Übergeordnetes Werk: |
volume:58 ; year:1981 ; month:02 ; pages:115-121 ; extent:7 |
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| 520 | |a Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk solution through the diffuse double layer theory and the Boltzman equations. We found that the dissociation constants for binding of Na+, K+ and Ca2+ in guinea pig taenia coli areca. 0.009, 1.0, and 4×10−8 m, respectively. Furthermore, the effect of a Ca2+ pump that maintains free surface Ca2+ concentration constant is investigated. A decrease in intracellular Na+ content results in an increased Ca2+ uptake; part of this uptake is due to an increase in surface-bound Ca2+ in an intracellular compartment which is in contact with the myofilaments. Variations in the amount of charge available to bind Ca2+ and the surface charge density are studied and their effect interpreted in terms of different pharmacological agents. | ||
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(DE-627)NLEJ207066620 DE-627 ger DE-627 rakwb eng Competitive membrane adsorption of Na+, K+, and Ca2+ in smooth muscle cells 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk solution through the diffuse double layer theory and the Boltzman equations. We found that the dissociation constants for binding of Na+, K+ and Ca2+ in guinea pig taenia coli areca. 0.009, 1.0, and 4×10−8 m, respectively. Furthermore, the effect of a Ca2+ pump that maintains free surface Ca2+ concentration constant is investigated. A decrease in intracellular Na+ content results in an increased Ca2+ uptake; part of this uptake is due to an increase in surface-bound Ca2+ in an intracellular compartment which is in contact with the myofilaments. Variations in the amount of charge available to bind Ca2+ and the surface charge density are studied and their effect interpreted in terms of different pharmacological agents. Springer Online Journal Archives 1860-2002 Kolber, Michael A. oth Breemen, Cornelis oth in The journal of membrane biology 1969 58(1981) vom: Feb., Seite 115-121 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:58 year:1981 month:02 pages:115-121 extent:7 http://dx.doi.org/10.1007/BF01870974 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 58 1981 2 115-121 7 |
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(DE-627)NLEJ207066620 DE-627 ger DE-627 rakwb eng Competitive membrane adsorption of Na+, K+, and Ca2+ in smooth muscle cells 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk solution through the diffuse double layer theory and the Boltzman equations. We found that the dissociation constants for binding of Na+, K+ and Ca2+ in guinea pig taenia coli areca. 0.009, 1.0, and 4×10−8 m, respectively. Furthermore, the effect of a Ca2+ pump that maintains free surface Ca2+ concentration constant is investigated. A decrease in intracellular Na+ content results in an increased Ca2+ uptake; part of this uptake is due to an increase in surface-bound Ca2+ in an intracellular compartment which is in contact with the myofilaments. Variations in the amount of charge available to bind Ca2+ and the surface charge density are studied and their effect interpreted in terms of different pharmacological agents. Springer Online Journal Archives 1860-2002 Kolber, Michael A. oth Breemen, Cornelis oth in The journal of membrane biology 1969 58(1981) vom: Feb., Seite 115-121 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:58 year:1981 month:02 pages:115-121 extent:7 http://dx.doi.org/10.1007/BF01870974 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 58 1981 2 115-121 7 |
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(DE-627)NLEJ207066620 DE-627 ger DE-627 rakwb eng Competitive membrane adsorption of Na+, K+, and Ca2+ in smooth muscle cells 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk solution through the diffuse double layer theory and the Boltzman equations. We found that the dissociation constants for binding of Na+, K+ and Ca2+ in guinea pig taenia coli areca. 0.009, 1.0, and 4×10−8 m, respectively. Furthermore, the effect of a Ca2+ pump that maintains free surface Ca2+ concentration constant is investigated. A decrease in intracellular Na+ content results in an increased Ca2+ uptake; part of this uptake is due to an increase in surface-bound Ca2+ in an intracellular compartment which is in contact with the myofilaments. Variations in the amount of charge available to bind Ca2+ and the surface charge density are studied and their effect interpreted in terms of different pharmacological agents. Springer Online Journal Archives 1860-2002 Kolber, Michael A. oth Breemen, Cornelis oth in The journal of membrane biology 1969 58(1981) vom: Feb., Seite 115-121 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:58 year:1981 month:02 pages:115-121 extent:7 http://dx.doi.org/10.1007/BF01870974 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 58 1981 2 115-121 7 |
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(DE-627)NLEJ207066620 DE-627 ger DE-627 rakwb eng Competitive membrane adsorption of Na+, K+, and Ca2+ in smooth muscle cells 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk solution through the diffuse double layer theory and the Boltzman equations. We found that the dissociation constants for binding of Na+, K+ and Ca2+ in guinea pig taenia coli areca. 0.009, 1.0, and 4×10−8 m, respectively. Furthermore, the effect of a Ca2+ pump that maintains free surface Ca2+ concentration constant is investigated. A decrease in intracellular Na+ content results in an increased Ca2+ uptake; part of this uptake is due to an increase in surface-bound Ca2+ in an intracellular compartment which is in contact with the myofilaments. Variations in the amount of charge available to bind Ca2+ and the surface charge density are studied and their effect interpreted in terms of different pharmacological agents. Springer Online Journal Archives 1860-2002 Kolber, Michael A. oth Breemen, Cornelis oth in The journal of membrane biology 1969 58(1981) vom: Feb., Seite 115-121 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:58 year:1981 month:02 pages:115-121 extent:7 http://dx.doi.org/10.1007/BF01870974 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 58 1981 2 115-121 7 |
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(DE-627)NLEJ207066620 DE-627 ger DE-627 rakwb eng Competitive membrane adsorption of Na+, K+, and Ca2+ in smooth muscle cells 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk solution through the diffuse double layer theory and the Boltzman equations. We found that the dissociation constants for binding of Na+, K+ and Ca2+ in guinea pig taenia coli areca. 0.009, 1.0, and 4×10−8 m, respectively. Furthermore, the effect of a Ca2+ pump that maintains free surface Ca2+ concentration constant is investigated. A decrease in intracellular Na+ content results in an increased Ca2+ uptake; part of this uptake is due to an increase in surface-bound Ca2+ in an intracellular compartment which is in contact with the myofilaments. Variations in the amount of charge available to bind Ca2+ and the surface charge density are studied and their effect interpreted in terms of different pharmacological agents. Springer Online Journal Archives 1860-2002 Kolber, Michael A. oth Breemen, Cornelis oth in The journal of membrane biology 1969 58(1981) vom: Feb., Seite 115-121 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:58 year:1981 month:02 pages:115-121 extent:7 http://dx.doi.org/10.1007/BF01870974 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 58 1981 2 115-121 7 |
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competitive membrane adsorption of na+, k+, and ca2+ in smooth muscle cells |
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Competitive membrane adsorption of Na+, K+, and Ca2+ in smooth muscle cells |
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Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk solution through the diffuse double layer theory and the Boltzman equations. We found that the dissociation constants for binding of Na+, K+ and Ca2+ in guinea pig taenia coli areca. 0.009, 1.0, and 4×10−8 m, respectively. Furthermore, the effect of a Ca2+ pump that maintains free surface Ca2+ concentration constant is investigated. A decrease in intracellular Na+ content results in an increased Ca2+ uptake; part of this uptake is due to an increase in surface-bound Ca2+ in an intracellular compartment which is in contact with the myofilaments. Variations in the amount of charge available to bind Ca2+ and the surface charge density are studied and their effect interpreted in terms of different pharmacological agents. |
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Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk solution through the diffuse double layer theory and the Boltzman equations. We found that the dissociation constants for binding of Na+, K+ and Ca2+ in guinea pig taenia coli areca. 0.009, 1.0, and 4×10−8 m, respectively. Furthermore, the effect of a Ca2+ pump that maintains free surface Ca2+ concentration constant is investigated. A decrease in intracellular Na+ content results in an increased Ca2+ uptake; part of this uptake is due to an increase in surface-bound Ca2+ in an intracellular compartment which is in contact with the myofilaments. Variations in the amount of charge available to bind Ca2+ and the surface charge density are studied and their effect interpreted in terms of different pharmacological agents. |
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Summary A theory for Na+, K+ and Ca2+ competitive adsorption to a charged membrane is used to explain a number of experimental observations in smooth muscle. Adsorption is described by Langmuir isotherms for mono- and divalent cations which in turn are coupled in a self-consistent way to the bulk solution through the diffuse double layer theory and the Boltzman equations. We found that the dissociation constants for binding of Na+, K+ and Ca2+ in guinea pig taenia coli areca. 0.009, 1.0, and 4×10−8 m, respectively. Furthermore, the effect of a Ca2+ pump that maintains free surface Ca2+ concentration constant is investigated. A decrease in intracellular Na+ content results in an increased Ca2+ uptake; part of this uptake is due to an increase in surface-bound Ca2+ in an intracellular compartment which is in contact with the myofilaments. Variations in the amount of charge available to bind Ca2+ and the surface charge density are studied and their effect interpreted in terms of different pharmacological agents. |
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