The effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes
Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1972 |
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| Umfang: |
34 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: The journal of membrane biology - 1969, 9(1972) vom: Jan., Seite 3-36 |
| Übergeordnetes Werk: |
volume:9 ; year:1972 ; month:01 ; pages:3-36 ; extent:34 |
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| 245 | 1 | 0 | |a The effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes |
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| 520 | |a Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII. | ||
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(DE-627)NLEJ20707450X DE-627 ger DE-627 rakwb eng The effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes 1972 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII. Springer Online Journal Archives 1860-2002 McLaughlin, S. G. A. oth Szabo, G. oth Ciani, S. oth Eisenman, G. oth in The journal of membrane biology 1969 9(1972) vom: Jan., Seite 3-36 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:9 year:1972 month:01 pages:3-36 extent:34 http://dx.doi.org/10.1007/BF01868041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 9 1972 1 3-36 34 |
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(DE-627)NLEJ20707450X DE-627 ger DE-627 rakwb eng The effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes 1972 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII. Springer Online Journal Archives 1860-2002 McLaughlin, S. G. A. oth Szabo, G. oth Ciani, S. oth Eisenman, G. oth in The journal of membrane biology 1969 9(1972) vom: Jan., Seite 3-36 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:9 year:1972 month:01 pages:3-36 extent:34 http://dx.doi.org/10.1007/BF01868041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 9 1972 1 3-36 34 |
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(DE-627)NLEJ20707450X DE-627 ger DE-627 rakwb eng The effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes 1972 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII. Springer Online Journal Archives 1860-2002 McLaughlin, S. G. A. oth Szabo, G. oth Ciani, S. oth Eisenman, G. oth in The journal of membrane biology 1969 9(1972) vom: Jan., Seite 3-36 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:9 year:1972 month:01 pages:3-36 extent:34 http://dx.doi.org/10.1007/BF01868041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 9 1972 1 3-36 34 |
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(DE-627)NLEJ20707450X DE-627 ger DE-627 rakwb eng The effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes 1972 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII. Springer Online Journal Archives 1860-2002 McLaughlin, S. G. A. oth Szabo, G. oth Ciani, S. oth Eisenman, G. oth in The journal of membrane biology 1969 9(1972) vom: Jan., Seite 3-36 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:9 year:1972 month:01 pages:3-36 extent:34 http://dx.doi.org/10.1007/BF01868041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 9 1972 1 3-36 34 |
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(DE-627)NLEJ20707450X DE-627 ger DE-627 rakwb eng The effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes 1972 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII. Springer Online Journal Archives 1860-2002 McLaughlin, S. G. A. oth Szabo, G. oth Ciani, S. oth Eisenman, G. oth in The journal of membrane biology 1969 9(1972) vom: Jan., Seite 3-36 (DE-627)NLEJ18899419X (DE-600)1459323-3 1432-1424 nnns volume:9 year:1972 month:01 pages:3-36 extent:34 http://dx.doi.org/10.1007/BF01868041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 9 1972 1 3-36 34 |
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the effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes |
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The effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes |
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Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII. |
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Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII. |
| abstract_unstemmed |
Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ20707450X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706220614.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1972 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ20707450X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The effects of a cyclic polyether on the electrical properties of phospholipid bilayer membranes</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1972</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">34</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary The cyclic polyether XXXII, a neutral, lipid soluble molecule, produces large increases in the conductance of bilayer membranes formed from a variety of lipids. The conductance increases linearly with the concentration of alkali metal cation but with the square, and at higher concentrations the cube, of the polyether concentration. This implies that two or three polyether molecules combine with a single cation to carry it across the membrane. In the presence of XXXII the bilayer is permeable solely to cations and the membrane potential is described by an equation of the Goldman-Hodgkin-Katz type. The permeability ratios determined from potential measurements are independent of salt concentration, decrease in the sequence Cs>Rb>K>NH4>Na>Li(1.0,0.25, 0.15, 0.075, 0.007, 0.0013) and are equal to the conductance ratios at low (e.g. 10−3 m) salt concentration. At higher salt concentrations, the permeability and conductance ratios are not equal and maxima in the conductancevs. salt concentration curves are observed. Both these phenomena are postulated to be caused by the formation of relatively impermeant 1ν1 polyether cation complexes in the aqueous phase. The 1ν1 aqueous association constants deduced from bilayer measurements decrease in the sequence K>Rb>Na>NH4>Cs>Li (120, 34, 26, 19, 12, 4 liters per mole) and agree quantitatively with the literature values for the more water soluble polyether XXXI, which lacks only thet-butyl groups of XXXII.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">McLaughlin, S. G. A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Szabo, G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ciani, S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Eisenman, G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">The journal of membrane biology</subfield><subfield code="d">1969</subfield><subfield code="g">9(1972) vom: Jan., Seite 3-36</subfield><subfield code="w">(DE-627)NLEJ18899419X</subfield><subfield code="w">(DE-600)1459323-3</subfield><subfield code="x">1432-1424</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:1972</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:3-36</subfield><subfield code="g">extent:34</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01868041</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">1972</subfield><subfield code="c">1</subfield><subfield code="h">3-36</subfield><subfield code="g">34</subfield></datafield></record></collection>
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7.400401 |