Spontaneous antibody-secreting cells in the stomach of gastric cancer patients
Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1996 |
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| Umfang: |
6 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Journal of gastroenterology - 1994, 31(1996) vom: Feb., Seite 161-166 |
| Übergeordnetes Werk: |
volume:31 ; year:1996 ; month:02 ; pages:161-166 ; extent:6 |
| Links: |
|---|
| Katalog-ID: |
NLEJ207619182 |
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| 520 | |a Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, in which IgA-, IgM-, and IgG-plaque-forming cells (PFC) were counted. The number of PFC was associated with the stage of cancer, but the response of lymphocytes in a non-tumorous area (NML) and tumor-infiltrating lymphocytes (TIL) differed. PFC in both sites were decreased compared to n0 cancer in n1 lymph node metastasis-positive cancer, while only NML showed raised PFC in n2+ (P<0.05, vs TIL). Cancer cells penetrating the submucosa caused the PFC of TIL (but not of NML) to decrease. Invasion of the intratumor capillary (V) or lymphatic (Ly) vessels also caused PFC to change, showing differences of Ig class; there was a decrease of PFC in V2 (IgG-and IgM-PFC) and in Ly2 (all Ig-PFC). IgA-PFC in Ly1 differed in TIL (decrease of PFC) and NML (increase). PFC also differed in TIL and NML in cancer cells, as follows: TIL<NML in tubular and poorly differentiated adenocarcinoma and TIL>NML in papillary and signet ring cell adenocarcinoma. Changes in lymph node (LNL) and blood lymphocytes were similar to those in gastric PFC whose IgA value was 10 times as much as that of LNL. The 5-year survival rate was significantly better in patients with lower rather than higher PFC such as 89% vs 68%. Gastric B cells thus appear to be active and to reflect gastric mucosal immunity. | ||
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| 700 | 1 | |a Kunori, Takao |4 oth | |
| 700 | 1 | |a Shinya, Fumiaki |4 oth | |
| 700 | 1 | |a Satomi, Takahiro |4 oth | |
| 700 | 1 | |a Itoh, Junzo |4 oth | |
| 700 | 1 | |a Abe, Michio |4 oth | |
| 700 | 1 | |a Takahashi, Masaru |4 oth | |
| 700 | 1 | |a Yokota, Takashi |4 oth | |
| 700 | 1 | |a Abe, Yutaka |4 oth | |
| 700 | 1 | |a Hiraoka, Kunihiko |4 oth | |
| 700 | 1 | |a Kawaguchi, Shinya |4 oth | |
| 700 | 1 | |a Tanaka, Ikuko |4 oth | |
| 700 | 1 | |a Mochizuki, Mamoru |4 oth | |
| 700 | 1 | |a Asano, Shigeyuki |4 oth | |
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(DE-627)NLEJ207619182 DE-627 ger DE-627 rakwb eng Spontaneous antibody-secreting cells in the stomach of gastric cancer patients 1996 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, in which IgA-, IgM-, and IgG-plaque-forming cells (PFC) were counted. The number of PFC was associated with the stage of cancer, but the response of lymphocytes in a non-tumorous area (NML) and tumor-infiltrating lymphocytes (TIL) differed. PFC in both sites were decreased compared to n0 cancer in n1 lymph node metastasis-positive cancer, while only NML showed raised PFC in n2+ (P<0.05, vs TIL). Cancer cells penetrating the submucosa caused the PFC of TIL (but not of NML) to decrease. Invasion of the intratumor capillary (V) or lymphatic (Ly) vessels also caused PFC to change, showing differences of Ig class; there was a decrease of PFC in V2 (IgG-and IgM-PFC) and in Ly2 (all Ig-PFC). IgA-PFC in Ly1 differed in TIL (decrease of PFC) and NML (increase). PFC also differed in TIL and NML in cancer cells, as follows: TIL<NML in tubular and poorly differentiated adenocarcinoma and TIL>NML in papillary and signet ring cell adenocarcinoma. Changes in lymph node (LNL) and blood lymphocytes were similar to those in gastric PFC whose IgA value was 10 times as much as that of LNL. The 5-year survival rate was significantly better in patients with lower rather than higher PFC such as 89% vs 68%. Gastric B cells thus appear to be active and to reflect gastric mucosal immunity. Springer Online Journal Archives 1860-2002 Kunori, Takao oth Shinya, Fumiaki oth Satomi, Takahiro oth Itoh, Junzo oth Abe, Michio oth Takahashi, Masaru oth Yokota, Takashi oth Abe, Yutaka oth Hiraoka, Kunihiko oth Kawaguchi, Shinya oth Tanaka, Ikuko oth Mochizuki, Mamoru oth Asano, Shigeyuki oth in Journal of gastroenterology 1994 31(1996) vom: Feb., Seite 161-166 (DE-627)NLEJ188987215 (DE-600)1473159-9 1435-5922 nnns volume:31 year:1996 month:02 pages:161-166 extent:6 http://dx.doi.org/10.1007/BF02389512 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 31 1996 2 161-166 6 |
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(DE-627)NLEJ207619182 DE-627 ger DE-627 rakwb eng Spontaneous antibody-secreting cells in the stomach of gastric cancer patients 1996 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, in which IgA-, IgM-, and IgG-plaque-forming cells (PFC) were counted. The number of PFC was associated with the stage of cancer, but the response of lymphocytes in a non-tumorous area (NML) and tumor-infiltrating lymphocytes (TIL) differed. PFC in both sites were decreased compared to n0 cancer in n1 lymph node metastasis-positive cancer, while only NML showed raised PFC in n2+ (P<0.05, vs TIL). Cancer cells penetrating the submucosa caused the PFC of TIL (but not of NML) to decrease. Invasion of the intratumor capillary (V) or lymphatic (Ly) vessels also caused PFC to change, showing differences of Ig class; there was a decrease of PFC in V2 (IgG-and IgM-PFC) and in Ly2 (all Ig-PFC). IgA-PFC in Ly1 differed in TIL (decrease of PFC) and NML (increase). PFC also differed in TIL and NML in cancer cells, as follows: TIL<NML in tubular and poorly differentiated adenocarcinoma and TIL>NML in papillary and signet ring cell adenocarcinoma. Changes in lymph node (LNL) and blood lymphocytes were similar to those in gastric PFC whose IgA value was 10 times as much as that of LNL. The 5-year survival rate was significantly better in patients with lower rather than higher PFC such as 89% vs 68%. Gastric B cells thus appear to be active and to reflect gastric mucosal immunity. Springer Online Journal Archives 1860-2002 Kunori, Takao oth Shinya, Fumiaki oth Satomi, Takahiro oth Itoh, Junzo oth Abe, Michio oth Takahashi, Masaru oth Yokota, Takashi oth Abe, Yutaka oth Hiraoka, Kunihiko oth Kawaguchi, Shinya oth Tanaka, Ikuko oth Mochizuki, Mamoru oth Asano, Shigeyuki oth in Journal of gastroenterology 1994 31(1996) vom: Feb., Seite 161-166 (DE-627)NLEJ188987215 (DE-600)1473159-9 1435-5922 nnns volume:31 year:1996 month:02 pages:161-166 extent:6 http://dx.doi.org/10.1007/BF02389512 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 31 1996 2 161-166 6 |
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(DE-627)NLEJ207619182 DE-627 ger DE-627 rakwb eng Spontaneous antibody-secreting cells in the stomach of gastric cancer patients 1996 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, in which IgA-, IgM-, and IgG-plaque-forming cells (PFC) were counted. The number of PFC was associated with the stage of cancer, but the response of lymphocytes in a non-tumorous area (NML) and tumor-infiltrating lymphocytes (TIL) differed. PFC in both sites were decreased compared to n0 cancer in n1 lymph node metastasis-positive cancer, while only NML showed raised PFC in n2+ (P<0.05, vs TIL). Cancer cells penetrating the submucosa caused the PFC of TIL (but not of NML) to decrease. Invasion of the intratumor capillary (V) or lymphatic (Ly) vessels also caused PFC to change, showing differences of Ig class; there was a decrease of PFC in V2 (IgG-and IgM-PFC) and in Ly2 (all Ig-PFC). IgA-PFC in Ly1 differed in TIL (decrease of PFC) and NML (increase). PFC also differed in TIL and NML in cancer cells, as follows: TIL<NML in tubular and poorly differentiated adenocarcinoma and TIL>NML in papillary and signet ring cell adenocarcinoma. Changes in lymph node (LNL) and blood lymphocytes were similar to those in gastric PFC whose IgA value was 10 times as much as that of LNL. The 5-year survival rate was significantly better in patients with lower rather than higher PFC such as 89% vs 68%. Gastric B cells thus appear to be active and to reflect gastric mucosal immunity. Springer Online Journal Archives 1860-2002 Kunori, Takao oth Shinya, Fumiaki oth Satomi, Takahiro oth Itoh, Junzo oth Abe, Michio oth Takahashi, Masaru oth Yokota, Takashi oth Abe, Yutaka oth Hiraoka, Kunihiko oth Kawaguchi, Shinya oth Tanaka, Ikuko oth Mochizuki, Mamoru oth Asano, Shigeyuki oth in Journal of gastroenterology 1994 31(1996) vom: Feb., Seite 161-166 (DE-627)NLEJ188987215 (DE-600)1473159-9 1435-5922 nnns volume:31 year:1996 month:02 pages:161-166 extent:6 http://dx.doi.org/10.1007/BF02389512 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 31 1996 2 161-166 6 |
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(DE-627)NLEJ207619182 DE-627 ger DE-627 rakwb eng Spontaneous antibody-secreting cells in the stomach of gastric cancer patients 1996 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, in which IgA-, IgM-, and IgG-plaque-forming cells (PFC) were counted. The number of PFC was associated with the stage of cancer, but the response of lymphocytes in a non-tumorous area (NML) and tumor-infiltrating lymphocytes (TIL) differed. PFC in both sites were decreased compared to n0 cancer in n1 lymph node metastasis-positive cancer, while only NML showed raised PFC in n2+ (P<0.05, vs TIL). Cancer cells penetrating the submucosa caused the PFC of TIL (but not of NML) to decrease. Invasion of the intratumor capillary (V) or lymphatic (Ly) vessels also caused PFC to change, showing differences of Ig class; there was a decrease of PFC in V2 (IgG-and IgM-PFC) and in Ly2 (all Ig-PFC). IgA-PFC in Ly1 differed in TIL (decrease of PFC) and NML (increase). PFC also differed in TIL and NML in cancer cells, as follows: TIL<NML in tubular and poorly differentiated adenocarcinoma and TIL>NML in papillary and signet ring cell adenocarcinoma. Changes in lymph node (LNL) and blood lymphocytes were similar to those in gastric PFC whose IgA value was 10 times as much as that of LNL. The 5-year survival rate was significantly better in patients with lower rather than higher PFC such as 89% vs 68%. Gastric B cells thus appear to be active and to reflect gastric mucosal immunity. Springer Online Journal Archives 1860-2002 Kunori, Takao oth Shinya, Fumiaki oth Satomi, Takahiro oth Itoh, Junzo oth Abe, Michio oth Takahashi, Masaru oth Yokota, Takashi oth Abe, Yutaka oth Hiraoka, Kunihiko oth Kawaguchi, Shinya oth Tanaka, Ikuko oth Mochizuki, Mamoru oth Asano, Shigeyuki oth in Journal of gastroenterology 1994 31(1996) vom: Feb., Seite 161-166 (DE-627)NLEJ188987215 (DE-600)1473159-9 1435-5922 nnns volume:31 year:1996 month:02 pages:161-166 extent:6 http://dx.doi.org/10.1007/BF02389512 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 31 1996 2 161-166 6 |
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(DE-627)NLEJ207619182 DE-627 ger DE-627 rakwb eng Spontaneous antibody-secreting cells in the stomach of gastric cancer patients 1996 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, in which IgA-, IgM-, and IgG-plaque-forming cells (PFC) were counted. The number of PFC was associated with the stage of cancer, but the response of lymphocytes in a non-tumorous area (NML) and tumor-infiltrating lymphocytes (TIL) differed. PFC in both sites were decreased compared to n0 cancer in n1 lymph node metastasis-positive cancer, while only NML showed raised PFC in n2+ (P<0.05, vs TIL). Cancer cells penetrating the submucosa caused the PFC of TIL (but not of NML) to decrease. Invasion of the intratumor capillary (V) or lymphatic (Ly) vessels also caused PFC to change, showing differences of Ig class; there was a decrease of PFC in V2 (IgG-and IgM-PFC) and in Ly2 (all Ig-PFC). IgA-PFC in Ly1 differed in TIL (decrease of PFC) and NML (increase). PFC also differed in TIL and NML in cancer cells, as follows: TIL<NML in tubular and poorly differentiated adenocarcinoma and TIL>NML in papillary and signet ring cell adenocarcinoma. Changes in lymph node (LNL) and blood lymphocytes were similar to those in gastric PFC whose IgA value was 10 times as much as that of LNL. The 5-year survival rate was significantly better in patients with lower rather than higher PFC such as 89% vs 68%. Gastric B cells thus appear to be active and to reflect gastric mucosal immunity. Springer Online Journal Archives 1860-2002 Kunori, Takao oth Shinya, Fumiaki oth Satomi, Takahiro oth Itoh, Junzo oth Abe, Michio oth Takahashi, Masaru oth Yokota, Takashi oth Abe, Yutaka oth Hiraoka, Kunihiko oth Kawaguchi, Shinya oth Tanaka, Ikuko oth Mochizuki, Mamoru oth Asano, Shigeyuki oth in Journal of gastroenterology 1994 31(1996) vom: Feb., Seite 161-166 (DE-627)NLEJ188987215 (DE-600)1473159-9 1435-5922 nnns volume:31 year:1996 month:02 pages:161-166 extent:6 http://dx.doi.org/10.1007/BF02389512 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 31 1996 2 161-166 6 |
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Elektronische Aufsätze |
| title_sort |
spontaneous antibody-secreting cells in the stomach of gastric cancer patients |
| title_auth |
Spontaneous antibody-secreting cells in the stomach of gastric cancer patients |
| abstract |
Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, in which IgA-, IgM-, and IgG-plaque-forming cells (PFC) were counted. The number of PFC was associated with the stage of cancer, but the response of lymphocytes in a non-tumorous area (NML) and tumor-infiltrating lymphocytes (TIL) differed. PFC in both sites were decreased compared to n0 cancer in n1 lymph node metastasis-positive cancer, while only NML showed raised PFC in n2+ (P<0.05, vs TIL). Cancer cells penetrating the submucosa caused the PFC of TIL (but not of NML) to decrease. Invasion of the intratumor capillary (V) or lymphatic (Ly) vessels also caused PFC to change, showing differences of Ig class; there was a decrease of PFC in V2 (IgG-and IgM-PFC) and in Ly2 (all Ig-PFC). IgA-PFC in Ly1 differed in TIL (decrease of PFC) and NML (increase). PFC also differed in TIL and NML in cancer cells, as follows: TIL<NML in tubular and poorly differentiated adenocarcinoma and TIL>NML in papillary and signet ring cell adenocarcinoma. Changes in lymph node (LNL) and blood lymphocytes were similar to those in gastric PFC whose IgA value was 10 times as much as that of LNL. The 5-year survival rate was significantly better in patients with lower rather than higher PFC such as 89% vs 68%. Gastric B cells thus appear to be active and to reflect gastric mucosal immunity. |
| abstractGer |
Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, in which IgA-, IgM-, and IgG-plaque-forming cells (PFC) were counted. The number of PFC was associated with the stage of cancer, but the response of lymphocytes in a non-tumorous area (NML) and tumor-infiltrating lymphocytes (TIL) differed. PFC in both sites were decreased compared to n0 cancer in n1 lymph node metastasis-positive cancer, while only NML showed raised PFC in n2+ (P<0.05, vs TIL). Cancer cells penetrating the submucosa caused the PFC of TIL (but not of NML) to decrease. Invasion of the intratumor capillary (V) or lymphatic (Ly) vessels also caused PFC to change, showing differences of Ig class; there was a decrease of PFC in V2 (IgG-and IgM-PFC) and in Ly2 (all Ig-PFC). IgA-PFC in Ly1 differed in TIL (decrease of PFC) and NML (increase). PFC also differed in TIL and NML in cancer cells, as follows: TIL<NML in tubular and poorly differentiated adenocarcinoma and TIL>NML in papillary and signet ring cell adenocarcinoma. Changes in lymph node (LNL) and blood lymphocytes were similar to those in gastric PFC whose IgA value was 10 times as much as that of LNL. The 5-year survival rate was significantly better in patients with lower rather than higher PFC such as 89% vs 68%. Gastric B cells thus appear to be active and to reflect gastric mucosal immunity. |
| abstract_unstemmed |
Abstract The gastric mucosa has been regarded as an active site of humoral immunity since the discovery ofHelicobacter pylori. The present study was conducted to determine the in vivo activity of gastric B cells in 53 gastric cancer patients. B-cell activity was measured by protein-A plaque assay, in which IgA-, IgM-, and IgG-plaque-forming cells (PFC) were counted. The number of PFC was associated with the stage of cancer, but the response of lymphocytes in a non-tumorous area (NML) and tumor-infiltrating lymphocytes (TIL) differed. PFC in both sites were decreased compared to n0 cancer in n1 lymph node metastasis-positive cancer, while only NML showed raised PFC in n2+ (P<0.05, vs TIL). Cancer cells penetrating the submucosa caused the PFC of TIL (but not of NML) to decrease. Invasion of the intratumor capillary (V) or lymphatic (Ly) vessels also caused PFC to change, showing differences of Ig class; there was a decrease of PFC in V2 (IgG-and IgM-PFC) and in Ly2 (all Ig-PFC). IgA-PFC in Ly1 differed in TIL (decrease of PFC) and NML (increase). PFC also differed in TIL and NML in cancer cells, as follows: TIL<NML in tubular and poorly differentiated adenocarcinoma and TIL>NML in papillary and signet ring cell adenocarcinoma. Changes in lymph node (LNL) and blood lymphocytes were similar to those in gastric PFC whose IgA value was 10 times as much as that of LNL. The 5-year survival rate was significantly better in patients with lower rather than higher PFC such as 89% vs 68%. Gastric B cells thus appear to be active and to reflect gastric mucosal immunity. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Spontaneous antibody-secreting cells in the stomach of gastric cancer patients |
| url |
http://dx.doi.org/10.1007/BF02389512 |
| remote_bool |
true |
| author2 |
Kunori, Takao Shinya, Fumiaki Satomi, Takahiro Itoh, Junzo Abe, Michio Takahashi, Masaru Yokota, Takashi Abe, Yutaka Hiraoka, Kunihiko Kawaguchi, Shinya Tanaka, Ikuko Mochizuki, Mamoru Asano, Shigeyuki |
| author2Str |
Kunori, Takao Shinya, Fumiaki Satomi, Takahiro Itoh, Junzo Abe, Michio Takahashi, Masaru Yokota, Takashi Abe, Yutaka Hiraoka, Kunihiko Kawaguchi, Shinya Tanaka, Ikuko Mochizuki, Mamoru Asano, Shigeyuki |
| ppnlink |
NLEJ188987215 |
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z |
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| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth oth oth oth oth oth oth |
| up_date |
2024-07-06T10:11:33.679Z |
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1803824077139345408 |
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7.3973246 |