Human breast carcinoma (ZR-75-1) serially transplanted into nude mice-with reference to estradiol dependency and sensitivity to tamoxifen
Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1989 |
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| Umfang: |
6 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Surgery today - 1971, 19(1989) vom: Apr., Seite 446-451 |
| Übergeordnetes Werk: |
volume:19 ; year:1989 ; month:04 ; pages:446-451 ; extent:6 |
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NLEJ207643148 |
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| 520 | |a Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen. | ||
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(DE-627)NLEJ207643148 DE-627 ger DE-627 rakwb eng Human breast carcinoma (ZR-75-1) serially transplanted into nude mice-with reference to estradiol dependency and sensitivity to tamoxifen 1989 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen. Springer Online Journal Archives 1860-2002 Kubota, Tetsuro oth Oka, Shoichi oth Utsumi, Toshiaki oth Inoue, So oth Kuzuoka, Masahiko oth Suto, Akihiko oth Arisawa, Yoshito oth Ishibiki, Kyuya oth Abe, Osahiko oth in Surgery today 1971 19(1989) vom: Apr., Seite 446-451 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:19 year:1989 month:04 pages:446-451 extent:6 http://dx.doi.org/10.1007/BF02471626 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1989 4 446-451 6 |
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(DE-627)NLEJ207643148 DE-627 ger DE-627 rakwb eng Human breast carcinoma (ZR-75-1) serially transplanted into nude mice-with reference to estradiol dependency and sensitivity to tamoxifen 1989 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen. Springer Online Journal Archives 1860-2002 Kubota, Tetsuro oth Oka, Shoichi oth Utsumi, Toshiaki oth Inoue, So oth Kuzuoka, Masahiko oth Suto, Akihiko oth Arisawa, Yoshito oth Ishibiki, Kyuya oth Abe, Osahiko oth in Surgery today 1971 19(1989) vom: Apr., Seite 446-451 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:19 year:1989 month:04 pages:446-451 extent:6 http://dx.doi.org/10.1007/BF02471626 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1989 4 446-451 6 |
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(DE-627)NLEJ207643148 DE-627 ger DE-627 rakwb eng Human breast carcinoma (ZR-75-1) serially transplanted into nude mice-with reference to estradiol dependency and sensitivity to tamoxifen 1989 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen. Springer Online Journal Archives 1860-2002 Kubota, Tetsuro oth Oka, Shoichi oth Utsumi, Toshiaki oth Inoue, So oth Kuzuoka, Masahiko oth Suto, Akihiko oth Arisawa, Yoshito oth Ishibiki, Kyuya oth Abe, Osahiko oth in Surgery today 1971 19(1989) vom: Apr., Seite 446-451 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:19 year:1989 month:04 pages:446-451 extent:6 http://dx.doi.org/10.1007/BF02471626 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1989 4 446-451 6 |
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(DE-627)NLEJ207643148 DE-627 ger DE-627 rakwb eng Human breast carcinoma (ZR-75-1) serially transplanted into nude mice-with reference to estradiol dependency and sensitivity to tamoxifen 1989 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen. Springer Online Journal Archives 1860-2002 Kubota, Tetsuro oth Oka, Shoichi oth Utsumi, Toshiaki oth Inoue, So oth Kuzuoka, Masahiko oth Suto, Akihiko oth Arisawa, Yoshito oth Ishibiki, Kyuya oth Abe, Osahiko oth in Surgery today 1971 19(1989) vom: Apr., Seite 446-451 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:19 year:1989 month:04 pages:446-451 extent:6 http://dx.doi.org/10.1007/BF02471626 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1989 4 446-451 6 |
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(DE-627)NLEJ207643148 DE-627 ger DE-627 rakwb eng Human breast carcinoma (ZR-75-1) serially transplanted into nude mice-with reference to estradiol dependency and sensitivity to tamoxifen 1989 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen. Springer Online Journal Archives 1860-2002 Kubota, Tetsuro oth Oka, Shoichi oth Utsumi, Toshiaki oth Inoue, So oth Kuzuoka, Masahiko oth Suto, Akihiko oth Arisawa, Yoshito oth Ishibiki, Kyuya oth Abe, Osahiko oth in Surgery today 1971 19(1989) vom: Apr., Seite 446-451 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:19 year:1989 month:04 pages:446-451 extent:6 http://dx.doi.org/10.1007/BF02471626 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1989 4 446-451 6 |
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Human breast carcinoma (ZR-75-1) serially transplanted into nude mice-with reference to estradiol dependency and sensitivity to tamoxifen |
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Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen. |
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Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen. |
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Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ207643148</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706233614.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1989 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ207643148</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Human breast carcinoma (ZR-75-1) serially transplanted into nude mice-with reference to estradiol dependency and sensitivity to tamoxifen</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1989</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Tumor cells of the ZR-75-1 line (1×107 in 0.5 ml) were inoculated into the right thigh muscles of BALB/c female nude mice which were, at the same time, given 1.0 mg of estradiol subcutaneously. After the transferable strain had been established, the tumors were then transplanted into female and male nude mice either with or without estradiol treatment. Although no exponential tumor growth was observed in the untreated male and female nude mice, no complete rejection was found during the experiments. The estrogen receptor of this strain was positive and the growth of ZR-75-1 was dependent on exogenous estradiol. ZR-75-1 in the nude mouse was insensitive to tamoxifen treatment, given as 5 mg/kg intramuscularly twice a week, suggesting that dependency on estradiol is not necessarily correlated with endocrine sensitivity to tamoxifen.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kubota, Tetsuro</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oka, Shoichi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Utsumi, Toshiaki</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Inoue, So</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kuzuoka, Masahiko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Suto, Akihiko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Arisawa, Yoshito</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ishibiki, Kyuya</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Abe, Osahiko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Surgery today</subfield><subfield code="d">1971</subfield><subfield code="g">19(1989) vom: Apr., Seite 446-451</subfield><subfield code="w">(DE-627)NLEJ188991352</subfield><subfield code="w">(DE-600)1463169-6</subfield><subfield code="x">1436-2813</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:19</subfield><subfield code="g">year:1989</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:446-451</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF02471626</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">19</subfield><subfield code="j">1989</subfield><subfield code="c">4</subfield><subfield code="h">446-451</subfield><subfield code="g">6</subfield></datafield></record></collection>
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