Effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system
Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1995 |
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| Umfang: |
10 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Surgery today - 1971, 25(1995) vom: Aug., Seite 701-710 |
| Übergeordnetes Werk: |
volume:25 ; year:1995 ; month:08 ; pages:701-710 ; extent:10 |
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NLEJ207654999 |
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| 520 | |a Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system. | ||
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| 700 | 1 | |a Abe, Osahiko |4 oth | |
| 700 | 1 | |a Asaishi, Kazuaki |4 oth | |
| 700 | 1 | |a Izuo, Masaru |4 oth | |
| 700 | 1 | |a Enomoto, Kohji |4 oth | |
| 700 | 1 | |a Koyama, Hiroki |4 oth | |
| 700 | 1 | |a Tominaga, Takeshi |4 oth | |
| 700 | 1 | |a Nomura, Yasuo |4 oth | |
| 700 | 1 | |a Ohshima, Akira |4 oth | |
| 700 | 1 | |a Aoki, Nobuo |4 oth | |
| 700 | 1 | |a Tsukada, Toshiyasu |4 oth | |
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(DE-627)NLEJ207654999 DE-627 ger DE-627 rakwb eng Effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system 1995 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system. Springer Online Journal Archives 1860-2002 Abe, Osahiko oth Asaishi, Kazuaki oth Izuo, Masaru oth Enomoto, Kohji oth Koyama, Hiroki oth Tominaga, Takeshi oth Nomura, Yasuo oth Ohshima, Akira oth Aoki, Nobuo oth Tsukada, Toshiyasu oth in Surgery today 1971 25(1995) vom: Aug., Seite 701-710 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:25 year:1995 month:08 pages:701-710 extent:10 http://dx.doi.org/10.1007/BF00311486 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1995 8 701-710 10 |
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(DE-627)NLEJ207654999 DE-627 ger DE-627 rakwb eng Effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system 1995 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system. Springer Online Journal Archives 1860-2002 Abe, Osahiko oth Asaishi, Kazuaki oth Izuo, Masaru oth Enomoto, Kohji oth Koyama, Hiroki oth Tominaga, Takeshi oth Nomura, Yasuo oth Ohshima, Akira oth Aoki, Nobuo oth Tsukada, Toshiyasu oth in Surgery today 1971 25(1995) vom: Aug., Seite 701-710 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:25 year:1995 month:08 pages:701-710 extent:10 http://dx.doi.org/10.1007/BF00311486 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1995 8 701-710 10 |
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(DE-627)NLEJ207654999 DE-627 ger DE-627 rakwb eng Effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system 1995 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system. Springer Online Journal Archives 1860-2002 Abe, Osahiko oth Asaishi, Kazuaki oth Izuo, Masaru oth Enomoto, Kohji oth Koyama, Hiroki oth Tominaga, Takeshi oth Nomura, Yasuo oth Ohshima, Akira oth Aoki, Nobuo oth Tsukada, Toshiyasu oth in Surgery today 1971 25(1995) vom: Aug., Seite 701-710 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:25 year:1995 month:08 pages:701-710 extent:10 http://dx.doi.org/10.1007/BF00311486 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1995 8 701-710 10 |
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(DE-627)NLEJ207654999 DE-627 ger DE-627 rakwb eng Effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system 1995 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system. Springer Online Journal Archives 1860-2002 Abe, Osahiko oth Asaishi, Kazuaki oth Izuo, Masaru oth Enomoto, Kohji oth Koyama, Hiroki oth Tominaga, Takeshi oth Nomura, Yasuo oth Ohshima, Akira oth Aoki, Nobuo oth Tsukada, Toshiyasu oth in Surgery today 1971 25(1995) vom: Aug., Seite 701-710 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:25 year:1995 month:08 pages:701-710 extent:10 http://dx.doi.org/10.1007/BF00311486 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1995 8 701-710 10 |
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(DE-627)NLEJ207654999 DE-627 ger DE-627 rakwb eng Effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system 1995 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system. Springer Online Journal Archives 1860-2002 Abe, Osahiko oth Asaishi, Kazuaki oth Izuo, Masaru oth Enomoto, Kohji oth Koyama, Hiroki oth Tominaga, Takeshi oth Nomura, Yasuo oth Ohshima, Akira oth Aoki, Nobuo oth Tsukada, Toshiyasu oth in Surgery today 1971 25(1995) vom: Aug., Seite 701-710 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:25 year:1995 month:08 pages:701-710 extent:10 http://dx.doi.org/10.1007/BF00311486 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1995 8 701-710 10 |
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effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system |
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Effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system |
| abstract |
Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system. |
| abstractGer |
Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system. |
| abstract_unstemmed |
Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system. |
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Effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system |
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Abe, Osahiko Asaishi, Kazuaki Izuo, Masaru Enomoto, Kohji Koyama, Hiroki Tominaga, Takeshi Nomura, Yasuo Ohshima, Akira Aoki, Nobuo Tsukada, Toshiyasu |
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Abe, Osahiko Asaishi, Kazuaki Izuo, Masaru Enomoto, Kohji Koyama, Hiroki Tominaga, Takeshi Nomura, Yasuo Ohshima, Akira Aoki, Nobuo Tsukada, Toshiyasu |
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