Preoperative chemotherapy for advanced esophageal cancer and relation with histological effect
Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in pa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1999 |
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| Umfang: |
6 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Surgery today - 1971, 29(1999) vom: Aug., Seite 689-694 |
| Übergeordnetes Werk: |
volume:29 ; year:1999 ; month:08 ; pages:689-694 ; extent:6 |
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| 520 | |a Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer. | ||
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| 700 | 1 | |a Shibusawa, Hiroyuki |4 oth | |
| 700 | 1 | |a Nagai, Hideo |4 oth | |
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| 700 | 1 | |a Nagashima, Toru |4 oth | |
| 700 | 1 | |a Kobayashi, Nobuhisa |4 oth | |
| 700 | 1 | |a Kanazawa, Kyotaro |4 oth | |
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(DE-627)NLEJ207668612 DE-627 ger DE-627 rakwb eng Preoperative chemotherapy for advanced esophageal cancer and relation with histological effect 1999 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer. Springer Online Journal Archives 1860-2002 Hosoya, Yoshinori oth Shibusawa, Hiroyuki oth Nagai, Hideo oth Ueno, Isao oth Sakuma, Kazuya oth Nagashima, Toru oth Kobayashi, Nobuhisa oth Kanazawa, Kyotaro oth in Surgery today 1971 29(1999) vom: Aug., Seite 689-694 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:29 year:1999 month:08 pages:689-694 extent:6 http://dx.doi.org/10.1007/BF02482310 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 8 689-694 6 |
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(DE-627)NLEJ207668612 DE-627 ger DE-627 rakwb eng Preoperative chemotherapy for advanced esophageal cancer and relation with histological effect 1999 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer. Springer Online Journal Archives 1860-2002 Hosoya, Yoshinori oth Shibusawa, Hiroyuki oth Nagai, Hideo oth Ueno, Isao oth Sakuma, Kazuya oth Nagashima, Toru oth Kobayashi, Nobuhisa oth Kanazawa, Kyotaro oth in Surgery today 1971 29(1999) vom: Aug., Seite 689-694 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:29 year:1999 month:08 pages:689-694 extent:6 http://dx.doi.org/10.1007/BF02482310 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 8 689-694 6 |
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(DE-627)NLEJ207668612 DE-627 ger DE-627 rakwb eng Preoperative chemotherapy for advanced esophageal cancer and relation with histological effect 1999 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer. Springer Online Journal Archives 1860-2002 Hosoya, Yoshinori oth Shibusawa, Hiroyuki oth Nagai, Hideo oth Ueno, Isao oth Sakuma, Kazuya oth Nagashima, Toru oth Kobayashi, Nobuhisa oth Kanazawa, Kyotaro oth in Surgery today 1971 29(1999) vom: Aug., Seite 689-694 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:29 year:1999 month:08 pages:689-694 extent:6 http://dx.doi.org/10.1007/BF02482310 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 8 689-694 6 |
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(DE-627)NLEJ207668612 DE-627 ger DE-627 rakwb eng Preoperative chemotherapy for advanced esophageal cancer and relation with histological effect 1999 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer. Springer Online Journal Archives 1860-2002 Hosoya, Yoshinori oth Shibusawa, Hiroyuki oth Nagai, Hideo oth Ueno, Isao oth Sakuma, Kazuya oth Nagashima, Toru oth Kobayashi, Nobuhisa oth Kanazawa, Kyotaro oth in Surgery today 1971 29(1999) vom: Aug., Seite 689-694 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:29 year:1999 month:08 pages:689-694 extent:6 http://dx.doi.org/10.1007/BF02482310 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 8 689-694 6 |
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(DE-627)NLEJ207668612 DE-627 ger DE-627 rakwb eng Preoperative chemotherapy for advanced esophageal cancer and relation with histological effect 1999 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer. Springer Online Journal Archives 1860-2002 Hosoya, Yoshinori oth Shibusawa, Hiroyuki oth Nagai, Hideo oth Ueno, Isao oth Sakuma, Kazuya oth Nagashima, Toru oth Kobayashi, Nobuhisa oth Kanazawa, Kyotaro oth in Surgery today 1971 29(1999) vom: Aug., Seite 689-694 (DE-627)NLEJ188991352 (DE-600)1463169-6 1436-2813 nnns volume:29 year:1999 month:08 pages:689-694 extent:6 http://dx.doi.org/10.1007/BF02482310 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 8 689-694 6 |
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Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer. |
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Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer. |
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Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ207668612</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706234017.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1999 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ207668612</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Preoperative chemotherapy for advanced esophageal cancer and relation with histological effect</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophageal cancer. Forty-nine patients with advanced esophageal squamous cell carcinoma were subjected to preoperative chemotherapy of cisplatin-5-fluorouracil. Fifty-seven patients were chosen as a historical control group who had not undergone chemotherapy before surgery but had the same histological stages as the chemotherapy group. The response to chemotherapy was assessed by histological studies of surgical specimens. The survival rates noted no significant difference between preoperative chemotherapy plus surgery and a resection alone. However, subclassification according to the grading of chemotherapeutic effectiveness showed that, compared with control, preoperative chemotherapy was beneficial to high responders (P=0.01), ineffective in low responders (P=0.61), and detrimental to nonresponders (P=0.03). Postoperative morbidity was significantly higher in the chemotherapy group than in the control group (P=0.02). These findings suggest that preoperative chemotherapy is necessary only for high responders and we therefore need to reliably identify non-, low, and high responders before chemotherapy to improve the survival and quality of life of patients with advanced esophageal cancer.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hosoya, Yoshinori</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shibusawa, Hiroyuki</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nagai, Hideo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ueno, Isao</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sakuma, Kazuya</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nagashima, Toru</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kobayashi, Nobuhisa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kanazawa, Kyotaro</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Surgery today</subfield><subfield code="d">1971</subfield><subfield code="g">29(1999) vom: Aug., Seite 689-694</subfield><subfield code="w">(DE-627)NLEJ188991352</subfield><subfield code="w">(DE-600)1463169-6</subfield><subfield code="x">1436-2813</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:29</subfield><subfield code="g">year:1999</subfield><subfield code="g">month:08</subfield><subfield code="g">pages:689-694</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF02482310</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">29</subfield><subfield code="j">1999</subfield><subfield code="c">8</subfield><subfield code="h">689-694</subfield><subfield code="g">6</subfield></datafield></record></collection>
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7.400529 |