Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma
Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2000 |
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| Umfang: |
6 |
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Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Gastric cancer - 1998, 3(2000) vom: Apr., Seite 187-192 |
| Übergeordnetes Werk: |
volume:3 ; year:2000 ; month:04 ; pages:187-192 ; extent:6 |
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NLEJ207701210 |
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| 245 | 1 | 0 | |a Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma |
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| 520 | |a Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma. | ||
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| 700 | 1 | |a Nomura, Eiji |4 oth | |
| 700 | 1 | |a Shinohara, Hisashi |4 oth | |
| 700 | 1 | |a Nakamura, Motoyuki |4 oth | |
| 700 | 1 | |a Nishiguchi, Kanji |4 oth | |
| 700 | 1 | |a Tanigawa, Nobuhiko |4 oth | |
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(DE-627)NLEJ207701210 DE-627 ger DE-627 rakwb eng Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma. Springer Online Journal Archives 1860-2002 Niki, Masami oth Toyoda, Masao oth Nomura, Eiji oth Shinohara, Hisashi oth Nakamura, Motoyuki oth Nishiguchi, Kanji oth Tanigawa, Nobuhiko oth in Gastric cancer 1998 3(2000) vom: Apr., Seite 187-192 (DE-627)NLEJ18899355X (DE-600)1481763-9 1436-3305 nnns volume:3 year:2000 month:04 pages:187-192 extent:6 http://dx.doi.org/10.1007/PL00011716 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 2000 4 187-192 6 |
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(DE-627)NLEJ207701210 DE-627 ger DE-627 rakwb eng Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma. Springer Online Journal Archives 1860-2002 Niki, Masami oth Toyoda, Masao oth Nomura, Eiji oth Shinohara, Hisashi oth Nakamura, Motoyuki oth Nishiguchi, Kanji oth Tanigawa, Nobuhiko oth in Gastric cancer 1998 3(2000) vom: Apr., Seite 187-192 (DE-627)NLEJ18899355X (DE-600)1481763-9 1436-3305 nnns volume:3 year:2000 month:04 pages:187-192 extent:6 http://dx.doi.org/10.1007/PL00011716 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 2000 4 187-192 6 |
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(DE-627)NLEJ207701210 DE-627 ger DE-627 rakwb eng Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma. Springer Online Journal Archives 1860-2002 Niki, Masami oth Toyoda, Masao oth Nomura, Eiji oth Shinohara, Hisashi oth Nakamura, Motoyuki oth Nishiguchi, Kanji oth Tanigawa, Nobuhiko oth in Gastric cancer 1998 3(2000) vom: Apr., Seite 187-192 (DE-627)NLEJ18899355X (DE-600)1481763-9 1436-3305 nnns volume:3 year:2000 month:04 pages:187-192 extent:6 http://dx.doi.org/10.1007/PL00011716 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 2000 4 187-192 6 |
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(DE-627)NLEJ207701210 DE-627 ger DE-627 rakwb eng Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma. Springer Online Journal Archives 1860-2002 Niki, Masami oth Toyoda, Masao oth Nomura, Eiji oth Shinohara, Hisashi oth Nakamura, Motoyuki oth Nishiguchi, Kanji oth Tanigawa, Nobuhiko oth in Gastric cancer 1998 3(2000) vom: Apr., Seite 187-192 (DE-627)NLEJ18899355X (DE-600)1481763-9 1436-3305 nnns volume:3 year:2000 month:04 pages:187-192 extent:6 http://dx.doi.org/10.1007/PL00011716 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 2000 4 187-192 6 |
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(DE-627)NLEJ207701210 DE-627 ger DE-627 rakwb eng Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma 2000 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma. Springer Online Journal Archives 1860-2002 Niki, Masami oth Toyoda, Masao oth Nomura, Eiji oth Shinohara, Hisashi oth Nakamura, Motoyuki oth Nishiguchi, Kanji oth Tanigawa, Nobuhiko oth in Gastric cancer 1998 3(2000) vom: Apr., Seite 187-192 (DE-627)NLEJ18899355X (DE-600)1481763-9 1436-3305 nnns volume:3 year:2000 month:04 pages:187-192 extent:6 http://dx.doi.org/10.1007/PL00011716 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 2000 4 187-192 6 |
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Niki, Masami @@oth@@ Toyoda, Masao @@oth@@ Nomura, Eiji @@oth@@ Shinohara, Hisashi @@oth@@ Nakamura, Motoyuki @@oth@@ Nishiguchi, Kanji @@oth@@ Tanigawa, Nobuhiko @@oth@@ |
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Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma |
| abstract |
Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma. |
| abstractGer |
Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma. |
| abstract_unstemmed |
Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma. |
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Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ207701210</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506100529.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s2000 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ207701210</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2000</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Niki, Masami</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Toyoda, Masao</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nomura, Eiji</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shinohara, Hisashi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nakamura, Motoyuki</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nishiguchi, Kanji</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tanigawa, Nobuhiko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Gastric cancer</subfield><subfield code="d">1998</subfield><subfield code="g">3(2000) vom: Apr., Seite 187-192</subfield><subfield code="w">(DE-627)NLEJ18899355X</subfield><subfield code="w">(DE-600)1481763-9</subfield><subfield code="x">1436-3305</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:2000</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:187-192</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/PL00011716</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">2000</subfield><subfield code="c">4</subfield><subfield code="h">187-192</subfield><subfield code="g">6</subfield></datafield></record></collection>
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