Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass
Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex...
Ausführliche Beschreibung
Autor*in: |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
1997 |
---|
Umfang: |
8 |
---|
Reproduktion: |
Springer Online Journal Archives 1860-2002 |
---|---|
Übergeordnetes Werk: |
in: Clinical and experimental nephrology - 1997, 1(1997) vom: März, Seite 187-194 |
Übergeordnetes Werk: |
volume:1 ; year:1997 ; month:03 ; pages:187-194 ; extent:8 |
Links: |
---|
Katalog-ID: |
NLEJ207706018 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLEJ207706018 | ||
003 | DE-627 | ||
005 | 20210706234545.0 | ||
007 | cr uuu---uuuuu | ||
008 | 070528s1997 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)NLEJ207706018 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
245 | 1 | 0 | |a Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass |
264 | 1 | |c 1997 | |
300 | |a 8 | ||
336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
337 | |a nicht spezifiziert |b z |2 rdamedia | ||
338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
520 | |a Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages. | ||
533 | |f Springer Online Journal Archives 1860-2002 | ||
700 | 1 | |a Konta, Tsuneo |4 oth | |
700 | 1 | |a Degawa, Noriyuki |4 oth | |
700 | 1 | |a Kato, Shuichi |4 oth | |
700 | 1 | |a Tomoike, Hitonobu |4 oth | |
773 | 0 | 8 | |i in |t Clinical and experimental nephrology |d 1997 |g 1(1997) vom: März, Seite 187-194 |w (DE-627)NLEJ188994696 |w (DE-600)1499111-1 |x 1437-7799 |7 nnns |
773 | 1 | 8 | |g volume:1 |g year:1997 |g month:03 |g pages:187-194 |g extent:8 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF02480694 |
912 | |a GBV_USEFLAG_U | ||
912 | |a ZDB-1-SOJ | ||
912 | |a GBV_NL_ARTICLE | ||
951 | |a AR | ||
952 | |d 1 |j 1997 |c 3 |h 187-194 |g 8 |
matchkey_str |
article:14377799:1997----::oefrnfrigrwhatrdrngoeuoceoiirt |
---|---|
hierarchy_sort_str |
1997 |
publishDate |
1997 |
allfields |
(DE-627)NLEJ207706018 DE-627 ger DE-627 rakwb eng Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass 1997 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages. Springer Online Journal Archives 1860-2002 Konta, Tsuneo oth Degawa, Noriyuki oth Kato, Shuichi oth Tomoike, Hitonobu oth in Clinical and experimental nephrology 1997 1(1997) vom: März, Seite 187-194 (DE-627)NLEJ188994696 (DE-600)1499111-1 1437-7799 nnns volume:1 year:1997 month:03 pages:187-194 extent:8 http://dx.doi.org/10.1007/BF02480694 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 1 1997 3 187-194 8 |
spelling |
(DE-627)NLEJ207706018 DE-627 ger DE-627 rakwb eng Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass 1997 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages. Springer Online Journal Archives 1860-2002 Konta, Tsuneo oth Degawa, Noriyuki oth Kato, Shuichi oth Tomoike, Hitonobu oth in Clinical and experimental nephrology 1997 1(1997) vom: März, Seite 187-194 (DE-627)NLEJ188994696 (DE-600)1499111-1 1437-7799 nnns volume:1 year:1997 month:03 pages:187-194 extent:8 http://dx.doi.org/10.1007/BF02480694 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 1 1997 3 187-194 8 |
allfields_unstemmed |
(DE-627)NLEJ207706018 DE-627 ger DE-627 rakwb eng Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass 1997 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages. Springer Online Journal Archives 1860-2002 Konta, Tsuneo oth Degawa, Noriyuki oth Kato, Shuichi oth Tomoike, Hitonobu oth in Clinical and experimental nephrology 1997 1(1997) vom: März, Seite 187-194 (DE-627)NLEJ188994696 (DE-600)1499111-1 1437-7799 nnns volume:1 year:1997 month:03 pages:187-194 extent:8 http://dx.doi.org/10.1007/BF02480694 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 1 1997 3 187-194 8 |
allfieldsGer |
(DE-627)NLEJ207706018 DE-627 ger DE-627 rakwb eng Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass 1997 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages. Springer Online Journal Archives 1860-2002 Konta, Tsuneo oth Degawa, Noriyuki oth Kato, Shuichi oth Tomoike, Hitonobu oth in Clinical and experimental nephrology 1997 1(1997) vom: März, Seite 187-194 (DE-627)NLEJ188994696 (DE-600)1499111-1 1437-7799 nnns volume:1 year:1997 month:03 pages:187-194 extent:8 http://dx.doi.org/10.1007/BF02480694 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 1 1997 3 187-194 8 |
allfieldsSound |
(DE-627)NLEJ207706018 DE-627 ger DE-627 rakwb eng Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass 1997 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages. Springer Online Journal Archives 1860-2002 Konta, Tsuneo oth Degawa, Noriyuki oth Kato, Shuichi oth Tomoike, Hitonobu oth in Clinical and experimental nephrology 1997 1(1997) vom: März, Seite 187-194 (DE-627)NLEJ188994696 (DE-600)1499111-1 1437-7799 nnns volume:1 year:1997 month:03 pages:187-194 extent:8 http://dx.doi.org/10.1007/BF02480694 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 1 1997 3 187-194 8 |
language |
English |
source |
in Clinical and experimental nephrology 1(1997) vom: März, Seite 187-194 volume:1 year:1997 month:03 pages:187-194 extent:8 |
sourceStr |
in Clinical and experimental nephrology 1(1997) vom: März, Seite 187-194 volume:1 year:1997 month:03 pages:187-194 extent:8 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
isfreeaccess_bool |
false |
container_title |
Clinical and experimental nephrology |
authorswithroles_txt_mv |
Konta, Tsuneo @@oth@@ Degawa, Noriyuki @@oth@@ Kato, Shuichi @@oth@@ Tomoike, Hitonobu @@oth@@ |
publishDateDaySort_date |
1997-03-01T00:00:00Z |
hierarchy_top_id |
NLEJ188994696 |
id |
NLEJ207706018 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ207706018</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706234545.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1997 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ207706018</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Konta, Tsuneo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Degawa, Noriyuki</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kato, Shuichi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tomoike, Hitonobu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Clinical and experimental nephrology</subfield><subfield code="d">1997</subfield><subfield code="g">1(1997) vom: März, Seite 187-194</subfield><subfield code="w">(DE-627)NLEJ188994696</subfield><subfield code="w">(DE-600)1499111-1</subfield><subfield code="x">1437-7799</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:1</subfield><subfield code="g">year:1997</subfield><subfield code="g">month:03</subfield><subfield code="g">pages:187-194</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF02480694</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">1</subfield><subfield code="j">1997</subfield><subfield code="c">3</subfield><subfield code="h">187-194</subfield><subfield code="g">8</subfield></datafield></record></collection>
|
series2 |
Springer Online Journal Archives 1860-2002 |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188994696 |
format |
electronic Article |
delete_txt_mv |
keep |
collection |
NL |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
1437-7799 |
topic_title |
Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
zu |
author2_variant |
t k tk n d nd s k sk h t ht |
hierarchy_parent_title |
Clinical and experimental nephrology |
hierarchy_parent_id |
NLEJ188994696 |
hierarchy_top_title |
Clinical and experimental nephrology |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)NLEJ188994696 (DE-600)1499111-1 |
title |
Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass |
spellingShingle |
Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass |
ctrlnum |
(DE-627)NLEJ207706018 |
title_full |
Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass |
journal |
Clinical and experimental nephrology |
journalStr |
Clinical and experimental nephrology |
lang_code |
eng |
isOA_bool |
false |
recordtype |
marc |
publishDateSort |
1997 |
contenttype_str_mv |
zzz |
container_start_page |
187 |
container_volume |
1 |
physical |
8 |
format_se |
Elektronische Aufsätze |
title_sort |
role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass |
title_auth |
Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass |
abstract |
Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages. |
abstractGer |
Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages. |
abstract_unstemmed |
Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages. |
collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
title_short |
Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass |
url |
http://dx.doi.org/10.1007/BF02480694 |
remote_bool |
true |
author2 |
Konta, Tsuneo Degawa, Noriyuki Kato, Shuichi Tomoike, Hitonobu |
author2Str |
Konta, Tsuneo Degawa, Noriyuki Kato, Shuichi Tomoike, Hitonobu |
ppnlink |
NLEJ188994696 |
mediatype_str_mv |
z |
isOA_txt |
false |
hochschulschrift_bool |
false |
author2_role |
oth oth oth oth |
up_date |
2024-07-06T10:26:58.628Z |
_version_ |
1803825047014473728 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ207706018</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706234545.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1997 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ207706018</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Role of transforming growth factor-β1 during glomerulosclerosis in rats with reduced renal mass</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background These studies were designed to investigate chronologic changes of transforming growth factor-β1 (TGF-β1) expression during the evolution of glomerulosclerosis in rats after partial nephrectomy. Methods The time course of TGF-β1 expression and its localization at the renal cortex was examined immunohistochemically in thirty-six 5/6 nephrectomized (Nx) and 30 sham-operated Wistar rats serially at 3 days and at 1,2,4,8 and 12 weeks after surgery. The extent of glomerulosclerosis was assessed by using the sclerosis index (index range, 0 to 4). Monocyte/macrophage infiltration and type IV collagen were immunohistochemically identified using the monoclonal antibody ED1 and monoclonal anti-type IV collagen antibody, respectively. Results At 12 weeks, the sclerosis index was 1.64±0.20 and 0.06±0.01 (P<0.0001, analysis of variance) in 5/6 nephrectomized and sham-operated rats, respectively. In the nephrectomized rats, the area of positive-TGF-β1 staining increased time-dependently, concomitant with positive results for ED1 and type IV collagen stainings. There was a strong topologic relationship among TGF-β1, ED1, and type IV collagen expression. Northern blot analysis of TGF-β1 messenger ribonucleic acid (mRNA) showed time-dependently augmented expression in nephrectomized, but not in shamoperated, rats (0.8-, 2.2-, 1.6,- and 3.4-fold at 1, 4, 8 and 12 weeks, respectively). Conclusion TGF-β1 plays a pivotal role in the progression of glomerulosclerosis in nephrectomized rats, in association with infiltration of monocytes/macrophages.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Konta, Tsuneo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Degawa, Noriyuki</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kato, Shuichi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tomoike, Hitonobu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Clinical and experimental nephrology</subfield><subfield code="d">1997</subfield><subfield code="g">1(1997) vom: März, Seite 187-194</subfield><subfield code="w">(DE-627)NLEJ188994696</subfield><subfield code="w">(DE-600)1499111-1</subfield><subfield code="x">1437-7799</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:1</subfield><subfield code="g">year:1997</subfield><subfield code="g">month:03</subfield><subfield code="g">pages:187-194</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF02480694</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">1</subfield><subfield code="j">1997</subfield><subfield code="c">3</subfield><subfield code="h">187-194</subfield><subfield code="g">8</subfield></datafield></record></collection>
|
score |
7.400485 |