The effect of intracranial hypotension on cerebral blood flow in a feline model
Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drain...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1993 |
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| Umfang: |
5 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Acta neurochirurgica - 1950, 122(1993) vom: Jan./Feb., Seite 113-117 |
| Übergeordnetes Werk: |
volume:122 ; year:1993 ; month:01/02 ; pages:113-117 ; extent:5 |
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NLEJ208088466 |
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| 245 | 1 | 0 | |a The effect of intracranial hypotension on cerebral blood flow in a feline model |
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| 520 | |a Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least −15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion. | ||
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| 700 | 1 | |a Shalit, M. N. |4 oth | |
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(DE-627)NLEJ208088466 DE-627 ger DE-627 rakwb eng The effect of intracranial hypotension on cerebral blood flow in a feline model 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least −15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion. Springer Online Journal Archives 1860-2002 Pomeranz, Sh. oth Beni, L. oth Shalit, M. N. oth in Acta neurochirurgica 1950 122(1993) vom: Jan./Feb., Seite 113-117 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:122 year:1993 month:01/02 pages:113-117 extent:5 http://dx.doi.org/10.1007/BF01446996 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 122 1993 1/2 113-117 5 |
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(DE-627)NLEJ208088466 DE-627 ger DE-627 rakwb eng The effect of intracranial hypotension on cerebral blood flow in a feline model 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least −15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion. Springer Online Journal Archives 1860-2002 Pomeranz, Sh. oth Beni, L. oth Shalit, M. N. oth in Acta neurochirurgica 1950 122(1993) vom: Jan./Feb., Seite 113-117 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:122 year:1993 month:01/02 pages:113-117 extent:5 http://dx.doi.org/10.1007/BF01446996 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 122 1993 1/2 113-117 5 |
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(DE-627)NLEJ208088466 DE-627 ger DE-627 rakwb eng The effect of intracranial hypotension on cerebral blood flow in a feline model 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least −15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion. Springer Online Journal Archives 1860-2002 Pomeranz, Sh. oth Beni, L. oth Shalit, M. N. oth in Acta neurochirurgica 1950 122(1993) vom: Jan./Feb., Seite 113-117 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:122 year:1993 month:01/02 pages:113-117 extent:5 http://dx.doi.org/10.1007/BF01446996 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 122 1993 1/2 113-117 5 |
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(DE-627)NLEJ208088466 DE-627 ger DE-627 rakwb eng The effect of intracranial hypotension on cerebral blood flow in a feline model 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least −15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion. Springer Online Journal Archives 1860-2002 Pomeranz, Sh. oth Beni, L. oth Shalit, M. N. oth in Acta neurochirurgica 1950 122(1993) vom: Jan./Feb., Seite 113-117 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:122 year:1993 month:01/02 pages:113-117 extent:5 http://dx.doi.org/10.1007/BF01446996 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 122 1993 1/2 113-117 5 |
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(DE-627)NLEJ208088466 DE-627 ger DE-627 rakwb eng The effect of intracranial hypotension on cerebral blood flow in a feline model 1993 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least −15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion. Springer Online Journal Archives 1860-2002 Pomeranz, Sh. oth Beni, L. oth Shalit, M. N. oth in Acta neurochirurgica 1950 122(1993) vom: Jan./Feb., Seite 113-117 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:122 year:1993 month:01/02 pages:113-117 extent:5 http://dx.doi.org/10.1007/BF01446996 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 122 1993 1/2 113-117 5 |
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the effect of intracranial hypotension on cerebral blood flow in a feline model |
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The effect of intracranial hypotension on cerebral blood flow in a feline model |
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Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least −15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion. |
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Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least −15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion. |
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Summary Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least −15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion. |
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