Effect of dotarizine on CO2-dependent cerebrovascular reactivity
Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1995 |
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| Umfang: |
3 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Acta neurochirurgica - 1950, 136(1995) vom: März/Apr., Seite 186-188 |
| Übergeordnetes Werk: |
volume:136 ; year:1995 ; month:03/04 ; pages:186-188 ; extent:3 |
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NLEJ208094261 |
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| 520 | |a Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain. | ||
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| 700 | 1 | |a Chomicki, J. |4 oth | |
| 700 | 1 | |a Jurkiewicz, J. |4 oth | |
| 700 | 1 | |a Zabolotny, W. |4 oth | |
| 700 | 1 | |a Czernicki, Z. |4 oth | |
| 700 | 1 | |a Cervos-Navarro, J. |4 oth | |
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(DE-627)NLEJ208094261 DE-627 ger DE-627 rakwb eng Effect of dotarizine on CO2-dependent cerebrovascular reactivity 1995 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain. Springer Online Journal Archives 1860-2002 Chomicki, J. oth Jurkiewicz, J. oth Zabolotny, W. oth Czernicki, Z. oth Cervos-Navarro, J. oth in Acta neurochirurgica 1950 136(1995) vom: März/Apr., Seite 186-188 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:136 year:1995 month:03/04 pages:186-188 extent:3 http://dx.doi.org/10.1007/BF01410624 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1995 3/4 186-188 3 |
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(DE-627)NLEJ208094261 DE-627 ger DE-627 rakwb eng Effect of dotarizine on CO2-dependent cerebrovascular reactivity 1995 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain. Springer Online Journal Archives 1860-2002 Chomicki, J. oth Jurkiewicz, J. oth Zabolotny, W. oth Czernicki, Z. oth Cervos-Navarro, J. oth in Acta neurochirurgica 1950 136(1995) vom: März/Apr., Seite 186-188 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:136 year:1995 month:03/04 pages:186-188 extent:3 http://dx.doi.org/10.1007/BF01410624 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1995 3/4 186-188 3 |
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(DE-627)NLEJ208094261 DE-627 ger DE-627 rakwb eng Effect of dotarizine on CO2-dependent cerebrovascular reactivity 1995 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain. Springer Online Journal Archives 1860-2002 Chomicki, J. oth Jurkiewicz, J. oth Zabolotny, W. oth Czernicki, Z. oth Cervos-Navarro, J. oth in Acta neurochirurgica 1950 136(1995) vom: März/Apr., Seite 186-188 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:136 year:1995 month:03/04 pages:186-188 extent:3 http://dx.doi.org/10.1007/BF01410624 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1995 3/4 186-188 3 |
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(DE-627)NLEJ208094261 DE-627 ger DE-627 rakwb eng Effect of dotarizine on CO2-dependent cerebrovascular reactivity 1995 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain. Springer Online Journal Archives 1860-2002 Chomicki, J. oth Jurkiewicz, J. oth Zabolotny, W. oth Czernicki, Z. oth Cervos-Navarro, J. oth in Acta neurochirurgica 1950 136(1995) vom: März/Apr., Seite 186-188 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:136 year:1995 month:03/04 pages:186-188 extent:3 http://dx.doi.org/10.1007/BF01410624 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1995 3/4 186-188 3 |
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(DE-627)NLEJ208094261 DE-627 ger DE-627 rakwb eng Effect of dotarizine on CO2-dependent cerebrovascular reactivity 1995 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain. Springer Online Journal Archives 1860-2002 Chomicki, J. oth Jurkiewicz, J. oth Zabolotny, W. oth Czernicki, Z. oth Cervos-Navarro, J. oth in Acta neurochirurgica 1950 136(1995) vom: März/Apr., Seite 186-188 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:136 year:1995 month:03/04 pages:186-188 extent:3 http://dx.doi.org/10.1007/BF01410624 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1995 3/4 186-188 3 |
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Effect of dotarizine on CO2-dependent cerebrovascular reactivity |
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Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain. |
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Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain. |
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Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ208094261</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506074334.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1995 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ208094261</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effect of dotarizine on CO2-dependent cerebrovascular reactivity</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">3</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chomicki, J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jurkiewicz, J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zabolotny, W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Czernicki, Z.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cervos-Navarro, J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Acta neurochirurgica</subfield><subfield code="d">1950</subfield><subfield code="g">136(1995) vom: März/Apr., Seite 186-188</subfield><subfield code="w">(DE-627)NLEJ188985085</subfield><subfield code="w">(DE-600)1464215-3</subfield><subfield code="x">0942-0940</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:136</subfield><subfield code="g">year:1995</subfield><subfield code="g">month:03/04</subfield><subfield code="g">pages:186-188</subfield><subfield code="g">extent:3</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01410624</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">136</subfield><subfield code="j">1995</subfield><subfield code="c">3/4</subfield><subfield code="h">186-188</subfield><subfield code="g">3</subfield></datafield></record></collection>
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