S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage
Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-1...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1997 |
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| Umfang: |
6 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Acta neurochirurgica - 1950, 139(1997) vom: Dez., Seite 1155-1160 |
| Übergeordnetes Werk: |
volume:139 ; year:1997 ; month:12 ; pages:1155-1160 ; extent:6 |
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NLEJ208097872 |
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| 520 | |a Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-100b on blood samples obtained 24 hours, 3 days and 7 days after onset of symptoms in patients with SAH and from 120 healthy control subjects. Neurological status was assessed using the Hunt and Hess (HH) scale on admission and by the Glasgow Outcome Scale (GOS) 6 months later. Mean concentrations of S-100 protein in blood were significantly (p<0.0001) higher in patients 24 hours (0.263±0.387 μg/l), 3 days (0.192±0.288 μg/l) and 7 days (0.256±0.442 μg/l) after onset of SAH symptoms compared to controls (0.050±0.081 μg/l). More severe neurological symptoms (higher HH scale scores) on admission correlated with higher S-100 levels on admission (R=0.70) and Day 3 (R=0.66) (p<0.0001). Worse outcome (lower GOS score) 6 months after SAH was also associated with higher plasma concentration of S-100 in the first week after SAH. In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). Measurement of S-100 protein in blood is a reliable non-invasive method and may be clinically useful to screen for and monitor progression of central nervous system diseases of various origins. | ||
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| 700 | 1 | |a Hagenström, H. |4 oth | |
| 700 | 1 | |a Gottmann, D. |4 oth | |
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(DE-627)NLEJ208097872 DE-627 ger DE-627 rakwb eng S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage 1997 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-100b on blood samples obtained 24 hours, 3 days and 7 days after onset of symptoms in patients with SAH and from 120 healthy control subjects. Neurological status was assessed using the Hunt and Hess (HH) scale on admission and by the Glasgow Outcome Scale (GOS) 6 months later. Mean concentrations of S-100 protein in blood were significantly (p<0.0001) higher in patients 24 hours (0.263±0.387 μg/l), 3 days (0.192±0.288 μg/l) and 7 days (0.256±0.442 μg/l) after onset of SAH symptoms compared to controls (0.050±0.081 μg/l). More severe neurological symptoms (higher HH scale scores) on admission correlated with higher S-100 levels on admission (R=0.70) and Day 3 (R=0.66) (p<0.0001). Worse outcome (lower GOS score) 6 months after SAH was also associated with higher plasma concentration of S-100 in the first week after SAH. In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). Measurement of S-100 protein in blood is a reliable non-invasive method and may be clinically useful to screen for and monitor progression of central nervous system diseases of various origins. Springer Online Journal Archives 1860-2002 Wiesmann, M. oth Missler, U. oth Hagenström, H. oth Gottmann, D. oth in Acta neurochirurgica 1950 139(1997) vom: Dez., Seite 1155-1160 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:139 year:1997 month:12 pages:1155-1160 extent:6 http://dx.doi.org/10.1007/BF01410976 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 139 1997 12 1155-1160 6 |
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(DE-627)NLEJ208097872 DE-627 ger DE-627 rakwb eng S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage 1997 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-100b on blood samples obtained 24 hours, 3 days and 7 days after onset of symptoms in patients with SAH and from 120 healthy control subjects. Neurological status was assessed using the Hunt and Hess (HH) scale on admission and by the Glasgow Outcome Scale (GOS) 6 months later. Mean concentrations of S-100 protein in blood were significantly (p<0.0001) higher in patients 24 hours (0.263±0.387 μg/l), 3 days (0.192±0.288 μg/l) and 7 days (0.256±0.442 μg/l) after onset of SAH symptoms compared to controls (0.050±0.081 μg/l). More severe neurological symptoms (higher HH scale scores) on admission correlated with higher S-100 levels on admission (R=0.70) and Day 3 (R=0.66) (p<0.0001). Worse outcome (lower GOS score) 6 months after SAH was also associated with higher plasma concentration of S-100 in the first week after SAH. In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). Measurement of S-100 protein in blood is a reliable non-invasive method and may be clinically useful to screen for and monitor progression of central nervous system diseases of various origins. Springer Online Journal Archives 1860-2002 Wiesmann, M. oth Missler, U. oth Hagenström, H. oth Gottmann, D. oth in Acta neurochirurgica 1950 139(1997) vom: Dez., Seite 1155-1160 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:139 year:1997 month:12 pages:1155-1160 extent:6 http://dx.doi.org/10.1007/BF01410976 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 139 1997 12 1155-1160 6 |
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(DE-627)NLEJ208097872 DE-627 ger DE-627 rakwb eng S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage 1997 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-100b on blood samples obtained 24 hours, 3 days and 7 days after onset of symptoms in patients with SAH and from 120 healthy control subjects. Neurological status was assessed using the Hunt and Hess (HH) scale on admission and by the Glasgow Outcome Scale (GOS) 6 months later. Mean concentrations of S-100 protein in blood were significantly (p<0.0001) higher in patients 24 hours (0.263±0.387 μg/l), 3 days (0.192±0.288 μg/l) and 7 days (0.256±0.442 μg/l) after onset of SAH symptoms compared to controls (0.050±0.081 μg/l). More severe neurological symptoms (higher HH scale scores) on admission correlated with higher S-100 levels on admission (R=0.70) and Day 3 (R=0.66) (p<0.0001). Worse outcome (lower GOS score) 6 months after SAH was also associated with higher plasma concentration of S-100 in the first week after SAH. In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). Measurement of S-100 protein in blood is a reliable non-invasive method and may be clinically useful to screen for and monitor progression of central nervous system diseases of various origins. Springer Online Journal Archives 1860-2002 Wiesmann, M. oth Missler, U. oth Hagenström, H. oth Gottmann, D. oth in Acta neurochirurgica 1950 139(1997) vom: Dez., Seite 1155-1160 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:139 year:1997 month:12 pages:1155-1160 extent:6 http://dx.doi.org/10.1007/BF01410976 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 139 1997 12 1155-1160 6 |
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(DE-627)NLEJ208097872 DE-627 ger DE-627 rakwb eng S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage 1997 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-100b on blood samples obtained 24 hours, 3 days and 7 days after onset of symptoms in patients with SAH and from 120 healthy control subjects. Neurological status was assessed using the Hunt and Hess (HH) scale on admission and by the Glasgow Outcome Scale (GOS) 6 months later. Mean concentrations of S-100 protein in blood were significantly (p<0.0001) higher in patients 24 hours (0.263±0.387 μg/l), 3 days (0.192±0.288 μg/l) and 7 days (0.256±0.442 μg/l) after onset of SAH symptoms compared to controls (0.050±0.081 μg/l). More severe neurological symptoms (higher HH scale scores) on admission correlated with higher S-100 levels on admission (R=0.70) and Day 3 (R=0.66) (p<0.0001). Worse outcome (lower GOS score) 6 months after SAH was also associated with higher plasma concentration of S-100 in the first week after SAH. In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). Measurement of S-100 protein in blood is a reliable non-invasive method and may be clinically useful to screen for and monitor progression of central nervous system diseases of various origins. Springer Online Journal Archives 1860-2002 Wiesmann, M. oth Missler, U. oth Hagenström, H. oth Gottmann, D. oth in Acta neurochirurgica 1950 139(1997) vom: Dez., Seite 1155-1160 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:139 year:1997 month:12 pages:1155-1160 extent:6 http://dx.doi.org/10.1007/BF01410976 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 139 1997 12 1155-1160 6 |
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(DE-627)NLEJ208097872 DE-627 ger DE-627 rakwb eng S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage 1997 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-100b on blood samples obtained 24 hours, 3 days and 7 days after onset of symptoms in patients with SAH and from 120 healthy control subjects. Neurological status was assessed using the Hunt and Hess (HH) scale on admission and by the Glasgow Outcome Scale (GOS) 6 months later. Mean concentrations of S-100 protein in blood were significantly (p<0.0001) higher in patients 24 hours (0.263±0.387 μg/l), 3 days (0.192±0.288 μg/l) and 7 days (0.256±0.442 μg/l) after onset of SAH symptoms compared to controls (0.050±0.081 μg/l). More severe neurological symptoms (higher HH scale scores) on admission correlated with higher S-100 levels on admission (R=0.70) and Day 3 (R=0.66) (p<0.0001). Worse outcome (lower GOS score) 6 months after SAH was also associated with higher plasma concentration of S-100 in the first week after SAH. In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). Measurement of S-100 protein in blood is a reliable non-invasive method and may be clinically useful to screen for and monitor progression of central nervous system diseases of various origins. Springer Online Journal Archives 1860-2002 Wiesmann, M. oth Missler, U. oth Hagenström, H. oth Gottmann, D. oth in Acta neurochirurgica 1950 139(1997) vom: Dez., Seite 1155-1160 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:139 year:1997 month:12 pages:1155-1160 extent:6 http://dx.doi.org/10.1007/BF01410976 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 139 1997 12 1155-1160 6 |
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In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). 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s-100 protein plasma levels after aneurysmal subarachnoid haemorrhage |
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S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage |
| abstract |
Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-100b on blood samples obtained 24 hours, 3 days and 7 days after onset of symptoms in patients with SAH and from 120 healthy control subjects. Neurological status was assessed using the Hunt and Hess (HH) scale on admission and by the Glasgow Outcome Scale (GOS) 6 months later. Mean concentrations of S-100 protein in blood were significantly (p<0.0001) higher in patients 24 hours (0.263±0.387 μg/l), 3 days (0.192±0.288 μg/l) and 7 days (0.256±0.442 μg/l) after onset of SAH symptoms compared to controls (0.050±0.081 μg/l). More severe neurological symptoms (higher HH scale scores) on admission correlated with higher S-100 levels on admission (R=0.70) and Day 3 (R=0.66) (p<0.0001). Worse outcome (lower GOS score) 6 months after SAH was also associated with higher plasma concentration of S-100 in the first week after SAH. In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). Measurement of S-100 protein in blood is a reliable non-invasive method and may be clinically useful to screen for and monitor progression of central nervous system diseases of various origins. |
| abstractGer |
Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-100b on blood samples obtained 24 hours, 3 days and 7 days after onset of symptoms in patients with SAH and from 120 healthy control subjects. Neurological status was assessed using the Hunt and Hess (HH) scale on admission and by the Glasgow Outcome Scale (GOS) 6 months later. Mean concentrations of S-100 protein in blood were significantly (p<0.0001) higher in patients 24 hours (0.263±0.387 μg/l), 3 days (0.192±0.288 μg/l) and 7 days (0.256±0.442 μg/l) after onset of SAH symptoms compared to controls (0.050±0.081 μg/l). More severe neurological symptoms (higher HH scale scores) on admission correlated with higher S-100 levels on admission (R=0.70) and Day 3 (R=0.66) (p<0.0001). Worse outcome (lower GOS score) 6 months after SAH was also associated with higher plasma concentration of S-100 in the first week after SAH. In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). Measurement of S-100 protein in blood is a reliable non-invasive method and may be clinically useful to screen for and monitor progression of central nervous system diseases of various origins. |
| abstract_unstemmed |
Summary We investigated the level of S-100 protein in blood as an indicator of brain damage in 71 patients suffering from subarachnoid haemorrhage (SAH) due to ruptured aneurysms. Concentrations of S-100 protein were determined by micro-titre based immunofluorometic assay detecting predominantly S-100b on blood samples obtained 24 hours, 3 days and 7 days after onset of symptoms in patients with SAH and from 120 healthy control subjects. Neurological status was assessed using the Hunt and Hess (HH) scale on admission and by the Glasgow Outcome Scale (GOS) 6 months later. Mean concentrations of S-100 protein in blood were significantly (p<0.0001) higher in patients 24 hours (0.263±0.387 μg/l), 3 days (0.192±0.288 μg/l) and 7 days (0.256±0.442 μg/l) after onset of SAH symptoms compared to controls (0.050±0.081 μg/l). More severe neurological symptoms (higher HH scale scores) on admission correlated with higher S-100 levels on admission (R=0.70) and Day 3 (R=0.66) (p<0.0001). Worse outcome (lower GOS score) 6 months after SAH was also associated with higher plasma concentration of S-100 in the first week after SAH. In summary, this study showed that in patients with SAH due to ruptured aneurysm, S-100 protein levels correlate with early neurological deficit and are as sensitive as HH scores in predicting neurological outcome (GOS scores). Measurement of S-100 protein in blood is a reliable non-invasive method and may be clinically useful to screen for and monitor progression of central nervous system diseases of various origins. |
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S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage |
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http://dx.doi.org/10.1007/BF01410976 |
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Wiesmann, M. Missler, U. Hagenström, H. Gottmann, D. |
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2024-07-06T11:14:27.631Z |
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