Aldosterone—A new therapeutic principle for the treatment of brain oedema in man
Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1974 |
|---|
| Umfang: |
10 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Acta neurochirurgica - 1950, 30(1974) vom: Jan./Feb., Seite 59-68 |
| Übergeordnetes Werk: |
volume:30 ; year:1974 ; month:01/02 ; pages:59-68 ; extent:10 |
| Links: |
|---|
| Katalog-ID: |
NLEJ208112499 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ208112499 | ||
| 003 | DE-627 | ||
| 005 | 20210707005010.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070528s1974 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ208112499 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Aldosterone—A new therapeutic principle for the treatment of brain oedema in man |
| 264 | 1 | |c 1974 | |
| 300 | |a 10 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Schmiedek, P. |4 oth | |
| 700 | 1 | |a Oettinger, W. |4 oth | |
| 700 | 1 | |a Baethmann, A. |4 oth | |
| 700 | 1 | |a Enzenbach, R. |4 oth | |
| 700 | 1 | |a Marguth, F. |4 oth | |
| 773 | 0 | 8 | |i in |t Acta neurochirurgica |d 1950 |g 30(1974) vom: Jan./Feb., Seite 59-68 |w (DE-627)NLEJ188985085 |w (DE-600)1464215-3 |x 0942-0940 |7 nnns |
| 773 | 1 | 8 | |g volume:30 |g year:1974 |g month:01/02 |g pages:59-68 |g extent:10 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF01405755 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 30 |j 1974 |c 1/2 |h 59-68 |g 10 | ||
| matchkey_str |
article:09420940:1974----::lotrnaeteaetcrnilfrhtetet |
|---|---|
| hierarchy_sort_str |
1974 |
| publishDate |
1974 |
| allfields |
(DE-627)NLEJ208112499 DE-627 ger DE-627 rakwb eng Aldosterone—A new therapeutic principle for the treatment of brain oedema in man 1974 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects. Springer Online Journal Archives 1860-2002 Schmiedek, P. oth Oettinger, W. oth Baethmann, A. oth Enzenbach, R. oth Marguth, F. oth in Acta neurochirurgica 1950 30(1974) vom: Jan./Feb., Seite 59-68 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:30 year:1974 month:01/02 pages:59-68 extent:10 http://dx.doi.org/10.1007/BF01405755 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1974 1/2 59-68 10 |
| spelling |
(DE-627)NLEJ208112499 DE-627 ger DE-627 rakwb eng Aldosterone—A new therapeutic principle for the treatment of brain oedema in man 1974 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects. Springer Online Journal Archives 1860-2002 Schmiedek, P. oth Oettinger, W. oth Baethmann, A. oth Enzenbach, R. oth Marguth, F. oth in Acta neurochirurgica 1950 30(1974) vom: Jan./Feb., Seite 59-68 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:30 year:1974 month:01/02 pages:59-68 extent:10 http://dx.doi.org/10.1007/BF01405755 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1974 1/2 59-68 10 |
| allfields_unstemmed |
(DE-627)NLEJ208112499 DE-627 ger DE-627 rakwb eng Aldosterone—A new therapeutic principle for the treatment of brain oedema in man 1974 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects. Springer Online Journal Archives 1860-2002 Schmiedek, P. oth Oettinger, W. oth Baethmann, A. oth Enzenbach, R. oth Marguth, F. oth in Acta neurochirurgica 1950 30(1974) vom: Jan./Feb., Seite 59-68 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:30 year:1974 month:01/02 pages:59-68 extent:10 http://dx.doi.org/10.1007/BF01405755 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1974 1/2 59-68 10 |
| allfieldsGer |
(DE-627)NLEJ208112499 DE-627 ger DE-627 rakwb eng Aldosterone—A new therapeutic principle for the treatment of brain oedema in man 1974 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects. Springer Online Journal Archives 1860-2002 Schmiedek, P. oth Oettinger, W. oth Baethmann, A. oth Enzenbach, R. oth Marguth, F. oth in Acta neurochirurgica 1950 30(1974) vom: Jan./Feb., Seite 59-68 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:30 year:1974 month:01/02 pages:59-68 extent:10 http://dx.doi.org/10.1007/BF01405755 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1974 1/2 59-68 10 |
| allfieldsSound |
(DE-627)NLEJ208112499 DE-627 ger DE-627 rakwb eng Aldosterone—A new therapeutic principle for the treatment of brain oedema in man 1974 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects. Springer Online Journal Archives 1860-2002 Schmiedek, P. oth Oettinger, W. oth Baethmann, A. oth Enzenbach, R. oth Marguth, F. oth in Acta neurochirurgica 1950 30(1974) vom: Jan./Feb., Seite 59-68 (DE-627)NLEJ188985085 (DE-600)1464215-3 0942-0940 nnns volume:30 year:1974 month:01/02 pages:59-68 extent:10 http://dx.doi.org/10.1007/BF01405755 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 30 1974 1/2 59-68 10 |
| language |
English |
| source |
in Acta neurochirurgica 30(1974) vom: Jan./Feb., Seite 59-68 volume:30 year:1974 month:01/02 pages:59-68 extent:10 |
| sourceStr |
in Acta neurochirurgica 30(1974) vom: Jan./Feb., Seite 59-68 volume:30 year:1974 month:01/02 pages:59-68 extent:10 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Acta neurochirurgica |
| authorswithroles_txt_mv |
Schmiedek, P. @@oth@@ Oettinger, W. @@oth@@ Baethmann, A. @@oth@@ Enzenbach, R. @@oth@@ Marguth, F. @@oth@@ |
| publishDateDaySort_date |
1974-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188985085 |
| id |
NLEJ208112499 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ208112499</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707005010.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1974 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ208112499</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Aldosterone—A new therapeutic principle for the treatment of brain oedema in man</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1974</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schmiedek, P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oettinger, W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Baethmann, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Enzenbach, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marguth, F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Acta neurochirurgica</subfield><subfield code="d">1950</subfield><subfield code="g">30(1974) vom: Jan./Feb., Seite 59-68</subfield><subfield code="w">(DE-627)NLEJ188985085</subfield><subfield code="w">(DE-600)1464215-3</subfield><subfield code="x">0942-0940</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:30</subfield><subfield code="g">year:1974</subfield><subfield code="g">month:01/02</subfield><subfield code="g">pages:59-68</subfield><subfield code="g">extent:10</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01405755</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">30</subfield><subfield code="j">1974</subfield><subfield code="c">1/2</subfield><subfield code="h">59-68</subfield><subfield code="g">10</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188985085 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
0942-0940 |
| topic_title |
Aldosterone—A new therapeutic principle for the treatment of brain oedema in man |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
p s ps w o wo a b ab r e re f m fm |
| hierarchy_parent_title |
Acta neurochirurgica |
| hierarchy_parent_id |
NLEJ188985085 |
| hierarchy_top_title |
Acta neurochirurgica |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188985085 (DE-600)1464215-3 |
| title |
Aldosterone—A new therapeutic principle for the treatment of brain oedema in man |
| spellingShingle |
Aldosterone—A new therapeutic principle for the treatment of brain oedema in man |
| ctrlnum |
(DE-627)NLEJ208112499 |
| title_full |
Aldosterone—A new therapeutic principle for the treatment of brain oedema in man |
| journal |
Acta neurochirurgica |
| journalStr |
Acta neurochirurgica |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1974 |
| contenttype_str_mv |
zzz |
| container_start_page |
59 |
| container_volume |
30 |
| physical |
10 |
| format_se |
Elektronische Aufsätze |
| title_sort |
aldosterone—a new therapeutic principle for the treatment of brain oedema in man |
| title_auth |
Aldosterone—A new therapeutic principle for the treatment of brain oedema in man |
| abstract |
Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects. |
| abstractGer |
Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects. |
| abstract_unstemmed |
Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Aldosterone—A new therapeutic principle for the treatment of brain oedema in man |
| url |
http://dx.doi.org/10.1007/BF01405755 |
| remote_bool |
true |
| author2 |
Schmiedek, P. Oettinger, W. Baethmann, A. Enzenbach, R. Marguth, F. |
| author2Str |
Schmiedek, P. Oettinger, W. Baethmann, A. Enzenbach, R. Marguth, F. |
| ppnlink |
NLEJ188985085 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth |
| up_date |
2024-07-06T11:17:05.748Z |
| _version_ |
1803828200209383424 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ208112499</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707005010.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1974 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ208112499</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Aldosterone—A new therapeutic principle for the treatment of brain oedema in man</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1974</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schmiedek, P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oettinger, W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Baethmann, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Enzenbach, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marguth, F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Acta neurochirurgica</subfield><subfield code="d">1950</subfield><subfield code="g">30(1974) vom: Jan./Feb., Seite 59-68</subfield><subfield code="w">(DE-627)NLEJ188985085</subfield><subfield code="w">(DE-600)1464215-3</subfield><subfield code="x">0942-0940</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:30</subfield><subfield code="g">year:1974</subfield><subfield code="g">month:01/02</subfield><subfield code="g">pages:59-68</subfield><subfield code="g">extent:10</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01405755</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">30</subfield><subfield code="j">1974</subfield><subfield code="c">1/2</subfield><subfield code="h">59-68</subfield><subfield code="g">10</subfield></datafield></record></collection>
|
| score |
7.3996267 |