Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)

Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its act...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Schoepp, D. D. Salhoff, C. R. Fuson, K. S. Sacaan, A. I. Tizzano, J. P. Ornstein, P. L. May, P. C.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	1996

Umfang:	12

Reproduktion:	Springer Online Journal Archives 1860-2002
Übergeordnetes Werk:	in: Journal of neural transmission - 1950, 103(1996) vom: Aug./Sept., Seite 905-916
Übergeordnetes Werk:	volume:103 ; year:1996 ; month:08/09 ; pages:905-916 ; extent:12

Links:	Link aufrufen

Katalog-ID:	NLEJ208139958

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245	1	0	\|a Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)
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520			\|a Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its active isomer (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic acid ((−)LY293558) and it's ± racemate (LY215490), was examined for neuroprotectant effects against excitotoxic injury in vitro and in vivo. This agent selectively protected against AMPA and kainate injury in cultured primary rat hippocampal neurons, an in vivo rat striatal neurotoxicity model, and against agonist-evoked seizures in mice. Thus, (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisguinoline-3-carboxylic acid represents a novel receptor selective and potent systemically active AMPA/kainate receptor antagonist for exploring neuroprotection via non-NMDA receptor mechanisms.
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matchkey_str	article:14351463:1996----::eetvpoetoaantmankiaevkdertxctb34rra61herzl5ltydchdosqioiec
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allfields	(DE-627)NLEJ208139958 DE-627 ger DE-627 rakwb eng Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490) 1996 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its active isomer (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic acid ((−)LY293558) and it's ± racemate (LY215490), was examined for neuroprotectant effects against excitotoxic injury in vitro and in vivo. This agent selectively protected against AMPA and kainate injury in cultured primary rat hippocampal neurons, an in vivo rat striatal neurotoxicity model, and against agonist-evoked seizures in mice. Thus, (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisguinoline-3-carboxylic acid represents a novel receptor selective and potent systemically active AMPA/kainate receptor antagonist for exploring neuroprotection via non-NMDA receptor mechanisms. Springer Online Journal Archives 1860-2002 Schoepp, D. D. oth Salhoff, C. R. oth Fuson, K. S. oth Sacaan, A. I. oth Tizzano, J. P. oth Ornstein, P. L. oth May, P. C. oth in Journal of neural transmission 1950 103(1996) vom: Aug./Sept., Seite 905-916 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:103 year:1996 month:08/09 pages:905-916 extent:12 http://dx.doi.org/10.1007/BF01291781 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 103 1996 8/9 905-916 12
spelling	(DE-627)NLEJ208139958 DE-627 ger DE-627 rakwb eng Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490) 1996 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its active isomer (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic acid ((−)LY293558) and it's ± racemate (LY215490), was examined for neuroprotectant effects against excitotoxic injury in vitro and in vivo. This agent selectively protected against AMPA and kainate injury in cultured primary rat hippocampal neurons, an in vivo rat striatal neurotoxicity model, and against agonist-evoked seizures in mice. Thus, (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisguinoline-3-carboxylic acid represents a novel receptor selective and potent systemically active AMPA/kainate receptor antagonist for exploring neuroprotection via non-NMDA receptor mechanisms. Springer Online Journal Archives 1860-2002 Schoepp, D. D. oth Salhoff, C. R. oth Fuson, K. S. oth Sacaan, A. I. oth Tizzano, J. P. oth Ornstein, P. L. oth May, P. C. oth in Journal of neural transmission 1950 103(1996) vom: Aug./Sept., Seite 905-916 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:103 year:1996 month:08/09 pages:905-916 extent:12 http://dx.doi.org/10.1007/BF01291781 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 103 1996 8/9 905-916 12
allfields_unstemmed	(DE-627)NLEJ208139958 DE-627 ger DE-627 rakwb eng Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490) 1996 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its active isomer (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic acid ((−)LY293558) and it's ± racemate (LY215490), was examined for neuroprotectant effects against excitotoxic injury in vitro and in vivo. This agent selectively protected against AMPA and kainate injury in cultured primary rat hippocampal neurons, an in vivo rat striatal neurotoxicity model, and against agonist-evoked seizures in mice. Thus, (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisguinoline-3-carboxylic acid represents a novel receptor selective and potent systemically active AMPA/kainate receptor antagonist for exploring neuroprotection via non-NMDA receptor mechanisms. Springer Online Journal Archives 1860-2002 Schoepp, D. D. oth Salhoff, C. R. oth Fuson, K. S. oth Sacaan, A. I. oth Tizzano, J. P. oth Ornstein, P. L. oth May, P. C. oth in Journal of neural transmission 1950 103(1996) vom: Aug./Sept., Seite 905-916 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:103 year:1996 month:08/09 pages:905-916 extent:12 http://dx.doi.org/10.1007/BF01291781 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 103 1996 8/9 905-916 12
allfieldsGer	(DE-627)NLEJ208139958 DE-627 ger DE-627 rakwb eng Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490) 1996 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its active isomer (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic acid ((−)LY293558) and it's ± racemate (LY215490), was examined for neuroprotectant effects against excitotoxic injury in vitro and in vivo. This agent selectively protected against AMPA and kainate injury in cultured primary rat hippocampal neurons, an in vivo rat striatal neurotoxicity model, and against agonist-evoked seizures in mice. Thus, (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisguinoline-3-carboxylic acid represents a novel receptor selective and potent systemically active AMPA/kainate receptor antagonist for exploring neuroprotection via non-NMDA receptor mechanisms. Springer Online Journal Archives 1860-2002 Schoepp, D. D. oth Salhoff, C. R. oth Fuson, K. S. oth Sacaan, A. I. oth Tizzano, J. P. oth Ornstein, P. L. oth May, P. C. oth in Journal of neural transmission 1950 103(1996) vom: Aug./Sept., Seite 905-916 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:103 year:1996 month:08/09 pages:905-916 extent:12 http://dx.doi.org/10.1007/BF01291781 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 103 1996 8/9 905-916 12
allfieldsSound	(DE-627)NLEJ208139958 DE-627 ger DE-627 rakwb eng Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490) 1996 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its active isomer (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic acid ((−)LY293558) and it's ± racemate (LY215490), was examined for neuroprotectant effects against excitotoxic injury in vitro and in vivo. This agent selectively protected against AMPA and kainate injury in cultured primary rat hippocampal neurons, an in vivo rat striatal neurotoxicity model, and against agonist-evoked seizures in mice. Thus, (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisguinoline-3-carboxylic acid represents a novel receptor selective and potent systemically active AMPA/kainate receptor antagonist for exploring neuroprotection via non-NMDA receptor mechanisms. Springer Online Journal Archives 1860-2002 Schoepp, D. D. oth Salhoff, C. R. oth Fuson, K. S. oth Sacaan, A. I. oth Tizzano, J. P. oth Ornstein, P. L. oth May, P. C. oth in Journal of neural transmission 1950 103(1996) vom: Aug./Sept., Seite 905-916 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:103 year:1996 month:08/09 pages:905-916 extent:12 http://dx.doi.org/10.1007/BF01291781 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 103 1996 8/9 905-916 12
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topic_title	Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)
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title	Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)
spellingShingle	Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)
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title_full	Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)
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title_sort	selective protection against ampa- and kainate-evoked neurotoxicity by (3s,4ar,6r,8ar)-6-[2-(1(2)h-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (ly293558) and its racemate (ly215490)
title_auth	Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)
abstract	Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its active isomer (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic acid ((−)LY293558) and it's ± racemate (LY215490), was examined for neuroprotectant effects against excitotoxic injury in vitro and in vivo. This agent selectively protected against AMPA and kainate injury in cultured primary rat hippocampal neurons, an in vivo rat striatal neurotoxicity model, and against agonist-evoked seizures in mice. Thus, (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisguinoline-3-carboxylic acid represents a novel receptor selective and potent systemically active AMPA/kainate receptor antagonist for exploring neuroprotection via non-NMDA receptor mechanisms.
abstractGer	Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its active isomer (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic acid ((−)LY293558) and it's ± racemate (LY215490), was examined for neuroprotectant effects against excitotoxic injury in vitro and in vivo. This agent selectively protected against AMPA and kainate injury in cultured primary rat hippocampal neurons, an in vivo rat striatal neurotoxicity model, and against agonist-evoked seizures in mice. Thus, (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisguinoline-3-carboxylic acid represents a novel receptor selective and potent systemically active AMPA/kainate receptor antagonist for exploring neuroprotection via non-NMDA receptor mechanisms.
abstract_unstemmed	Summary Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the novel glutamate receptor antagonist, as its active isomer (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic acid ((−)LY293558) and it's ± racemate (LY215490), was examined for neuroprotectant effects against excitotoxic injury in vitro and in vivo. This agent selectively protected against AMPA and kainate injury in cultured primary rat hippocampal neurons, an in vivo rat striatal neurotoxicity model, and against agonist-evoked seizures in mice. Thus, (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisguinoline-3-carboxylic acid represents a novel receptor selective and potent systemically active AMPA/kainate receptor antagonist for exploring neuroprotection via non-NMDA receptor mechanisms.
collection_details	GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE
title_short	Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)
url	http://dx.doi.org/10.1007/BF01291781
remote_bool	true
author2	Schoepp, D. D. Salhoff, C. R. Fuson, K. S. Sacaan, A. I. Tizzano, J. P. Ornstein, P. L. May, P. C.
author2Str	Schoepp, D. D. Salhoff, C. R. Fuson, K. S. Sacaan, A. I. Tizzano, J. P. Ornstein, P. L. May, P. C.
ppnlink	NLEJ188994017
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isOA_txt	false
hochschulschrift_bool	false
author2_role	oth oth oth oth oth oth oth
up_date	2024-07-06T11:21:09.978Z
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Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)

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