Effects of increasing doses of apomorphine during stereotaxic neurosurgery in Parkinson's disease: clinical score and internal globus pallidus activity
Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1997 |
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| Umfang: |
10 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Journal of neural transmission - 1950, 104(1997) vom: Aug./Sept., Seite 895-904 |
| Übergeordnetes Werk: |
volume:104 ; year:1997 ; month:08/09 ; pages:895-904 ; extent:10 |
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NLEJ208141332 |
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| 520 | |a Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias. | ||
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| 700 | 1 | |a Vangelista, T. |4 oth | |
| 700 | 1 | |a Bernardi, G. |4 oth | |
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(DE-627)NLEJ208141332 DE-627 ger DE-627 rakwb eng Effects of increasing doses of apomorphine during stereotaxic neurosurgery in Parkinson's disease: clinical score and internal globus pallidus activity 1997 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias. Springer Online Journal Archives 1860-2002 Stefani, A. oth Stanzione, P. oth Bassi, A. oth Mazzone, P. oth Vangelista, T. oth Bernardi, G. oth in Journal of neural transmission 1950 104(1997) vom: Aug./Sept., Seite 895-904 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:104 year:1997 month:08/09 pages:895-904 extent:10 http://dx.doi.org/10.1007/BF01285557 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 104 1997 8/9 895-904 10 |
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(DE-627)NLEJ208141332 DE-627 ger DE-627 rakwb eng Effects of increasing doses of apomorphine during stereotaxic neurosurgery in Parkinson's disease: clinical score and internal globus pallidus activity 1997 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias. Springer Online Journal Archives 1860-2002 Stefani, A. oth Stanzione, P. oth Bassi, A. oth Mazzone, P. oth Vangelista, T. oth Bernardi, G. oth in Journal of neural transmission 1950 104(1997) vom: Aug./Sept., Seite 895-904 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:104 year:1997 month:08/09 pages:895-904 extent:10 http://dx.doi.org/10.1007/BF01285557 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 104 1997 8/9 895-904 10 |
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(DE-627)NLEJ208141332 DE-627 ger DE-627 rakwb eng Effects of increasing doses of apomorphine during stereotaxic neurosurgery in Parkinson's disease: clinical score and internal globus pallidus activity 1997 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias. Springer Online Journal Archives 1860-2002 Stefani, A. oth Stanzione, P. oth Bassi, A. oth Mazzone, P. oth Vangelista, T. oth Bernardi, G. oth in Journal of neural transmission 1950 104(1997) vom: Aug./Sept., Seite 895-904 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:104 year:1997 month:08/09 pages:895-904 extent:10 http://dx.doi.org/10.1007/BF01285557 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 104 1997 8/9 895-904 10 |
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(DE-627)NLEJ208141332 DE-627 ger DE-627 rakwb eng Effects of increasing doses of apomorphine during stereotaxic neurosurgery in Parkinson's disease: clinical score and internal globus pallidus activity 1997 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias. Springer Online Journal Archives 1860-2002 Stefani, A. oth Stanzione, P. oth Bassi, A. oth Mazzone, P. oth Vangelista, T. oth Bernardi, G. oth in Journal of neural transmission 1950 104(1997) vom: Aug./Sept., Seite 895-904 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:104 year:1997 month:08/09 pages:895-904 extent:10 http://dx.doi.org/10.1007/BF01285557 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 104 1997 8/9 895-904 10 |
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(DE-627)NLEJ208141332 DE-627 ger DE-627 rakwb eng Effects of increasing doses of apomorphine during stereotaxic neurosurgery in Parkinson's disease: clinical score and internal globus pallidus activity 1997 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias. Springer Online Journal Archives 1860-2002 Stefani, A. oth Stanzione, P. oth Bassi, A. oth Mazzone, P. oth Vangelista, T. oth Bernardi, G. oth in Journal of neural transmission 1950 104(1997) vom: Aug./Sept., Seite 895-904 (DE-627)NLEJ188994017 (DE-600)1481655-6 1435-1463 nnns volume:104 year:1997 month:08/09 pages:895-904 extent:10 http://dx.doi.org/10.1007/BF01285557 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 104 1997 8/9 895-904 10 |
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effects of increasing doses of apomorphine during stereotaxic neurosurgery in parkinson's disease: clinical score and internal globus pallidus activity |
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Effects of increasing doses of apomorphine during stereotaxic neurosurgery in Parkinson's disease: clinical score and internal globus pallidus activity |
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Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias. |
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Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias. |
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Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ208141332</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506074409.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070528s1997 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ208141332</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effects of increasing doses of apomorphine during stereotaxic neurosurgery in Parkinson's disease: clinical score and internal globus pallidus activity</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1–2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by >50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Stefani, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Stanzione, P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bassi, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mazzone, P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vangelista, T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bernardi, G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Journal of neural transmission</subfield><subfield code="d">1950</subfield><subfield code="g">104(1997) vom: Aug./Sept., Seite 895-904</subfield><subfield code="w">(DE-627)NLEJ188994017</subfield><subfield code="w">(DE-600)1481655-6</subfield><subfield code="x">1435-1463</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:104</subfield><subfield code="g">year:1997</subfield><subfield code="g">month:08/09</subfield><subfield code="g">pages:895-904</subfield><subfield code="g">extent:10</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01285557</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">104</subfield><subfield code="j">1997</subfield><subfield code="c">8/9</subfield><subfield code="h">895-904</subfield><subfield code="g">10</subfield></datafield></record></collection>
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