Both Rb/p16 INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
[Auszug] Normal human cells undergo a limited number of divisions in culture and enter a non-dividing state called replicative senescence. Senescence is accompanied by several changes, including an increase in inhibitors of cyclin-dependent kinases, and telomere shortening. The mechanisms by which v...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kiyono, Tohru [verfasserIn] Foster, Scott A. [verfasserIn] Koop, Jenn I. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
s.l.: Macmillan Magazines Ltd. ; 1998 |
|---|
| Umfang: |
5 |
|---|
| Reproduktion: |
Nature Archives 1869 - 2009 |
|---|---|
| Übergeordnetes Werk: |
In: Nature |
| Übergeordnetes Werk: |
volume:396 ; year:1998 ; number:6706 ; month:00 ; pages:84-88 ; extent:5 |
| Links: |
|---|
| DOI / URN: |
10.1038/23962 |
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10.1038/23962 doi (DE-627)NLEJ234946377 DE-627 ger DE-627 rakwb eng Kiyono, Tohru verfasserin aut Both Rb/p16 INK4a inactivation and telomerase activity are required to immortalize human epithelial cells [s.l.] Macmillan Magazines Ltd. 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier [Auszug] Normal human cells undergo a limited number of divisions in culture and enter a non-dividing state called replicative senescence. Senescence is accompanied by several changes, including an increase in inhibitors of cyclin-dependent kinases, and telomere shortening. The mechanisms by which viral ... Nature Archives 1869 - 2009 Foster, Scott A. verfasserin aut Koop, Jenn I. verfasserin aut McDougall, James K. oth Klingelhutz, Aloysius J. oth Galloway, Denise A. oth In Nature <London> London [u.a.] : Nature Publising Group, 1869 396(1998), 6706, Seite 84-88 (DE-627)NLEJ227682335 (DE-600)1413423-8 1476-4687 nnns volume:396 year:1998 number:6706 month:00 pages:84-88 extent:5 http://dx.doi.org/10.1038/23962 application/pdf Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-NTA GBV_NL_ARTICLE AR 396 1998 6706 0 84-88 5 |
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10.1038/23962 doi (DE-627)NLEJ234946377 DE-627 ger DE-627 rakwb eng Kiyono, Tohru verfasserin aut Both Rb/p16 INK4a inactivation and telomerase activity are required to immortalize human epithelial cells [s.l.] Macmillan Magazines Ltd. 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier [Auszug] Normal human cells undergo a limited number of divisions in culture and enter a non-dividing state called replicative senescence. Senescence is accompanied by several changes, including an increase in inhibitors of cyclin-dependent kinases, and telomere shortening. The mechanisms by which viral ... Nature Archives 1869 - 2009 Foster, Scott A. verfasserin aut Koop, Jenn I. verfasserin aut McDougall, James K. oth Klingelhutz, Aloysius J. oth Galloway, Denise A. oth In Nature <London> London [u.a.] : Nature Publising Group, 1869 396(1998), 6706, Seite 84-88 (DE-627)NLEJ227682335 (DE-600)1413423-8 1476-4687 nnns volume:396 year:1998 number:6706 month:00 pages:84-88 extent:5 http://dx.doi.org/10.1038/23962 application/pdf Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-NTA GBV_NL_ARTICLE AR 396 1998 6706 0 84-88 5 |
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10.1038/23962 doi (DE-627)NLEJ234946377 DE-627 ger DE-627 rakwb eng Kiyono, Tohru verfasserin aut Both Rb/p16 INK4a inactivation and telomerase activity are required to immortalize human epithelial cells [s.l.] Macmillan Magazines Ltd. 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier [Auszug] Normal human cells undergo a limited number of divisions in culture and enter a non-dividing state called replicative senescence. Senescence is accompanied by several changes, including an increase in inhibitors of cyclin-dependent kinases, and telomere shortening. The mechanisms by which viral ... Nature Archives 1869 - 2009 Foster, Scott A. verfasserin aut Koop, Jenn I. verfasserin aut McDougall, James K. oth Klingelhutz, Aloysius J. oth Galloway, Denise A. oth In Nature <London> London [u.a.] : Nature Publising Group, 1869 396(1998), 6706, Seite 84-88 (DE-627)NLEJ227682335 (DE-600)1413423-8 1476-4687 nnns volume:396 year:1998 number:6706 month:00 pages:84-88 extent:5 http://dx.doi.org/10.1038/23962 application/pdf Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-NTA GBV_NL_ARTICLE AR 396 1998 6706 0 84-88 5 |
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[Auszug] Normal human cells undergo a limited number of divisions in culture and enter a non-dividing state called replicative senescence. Senescence is accompanied by several changes, including an increase in inhibitors of cyclin-dependent kinases, and telomere shortening. The mechanisms by which viral ... |
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