Decreased collagen-induced platelet aggregation and increased platelet arginine levels in migraine: a possible link with the NO pathway
We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to col...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
D'Andrea, G [verfasserIn] Cananzi, AR [verfasserIn] Perini, F [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
USA/Oxford, UK: Blackwell Science Ltd ; 1994 |
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| Schlagwörter: |
|---|
| Umfang: |
Online-Ressource |
|---|
| Reproduktion: |
2002 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Cephalalgia - London [u.a.] : Sage, 1981, 14(1994), 5, Seite 0 |
| Übergeordnetes Werk: |
volume:14 ; year:1994 ; number:5 ; pages:0 |
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| DOI / URN: |
10.1046/j.1468-2982.1994.1405352.x |
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| 520 | |a We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis. | ||
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10.1046/j.1468-2982.1994.1405352.x doi (DE-627)NLEJ238585603 DE-627 ger DE-627 rakwb D'Andrea, G verfasserin aut Decreased collagen-induced platelet aggregation and increased platelet arginine levels in migraine: a possible link with the NO pathway USA/Oxford, UK Blackwell Science Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| L-arginine Cananzi, AR verfasserin aut Perini, F verfasserin aut Alecci, M oth Zamberlan, F oth Hasselmark, L oth Welch, KMA oth In Cephalalgia London [u.a.] : Sage, 1981 14(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926839 (DE-600)2019999-5 1468-2982 nnns volume:14 year:1994 number:5 pages:0 http://dx.doi.org/10.1046/j.1468-2982.1994.1405352.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1994 5 0 |
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10.1046/j.1468-2982.1994.1405352.x doi (DE-627)NLEJ238585603 DE-627 ger DE-627 rakwb D'Andrea, G verfasserin aut Decreased collagen-induced platelet aggregation and increased platelet arginine levels in migraine: a possible link with the NO pathway USA/Oxford, UK Blackwell Science Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| L-arginine Cananzi, AR verfasserin aut Perini, F verfasserin aut Alecci, M oth Zamberlan, F oth Hasselmark, L oth Welch, KMA oth In Cephalalgia London [u.a.] : Sage, 1981 14(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926839 (DE-600)2019999-5 1468-2982 nnns volume:14 year:1994 number:5 pages:0 http://dx.doi.org/10.1046/j.1468-2982.1994.1405352.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1994 5 0 |
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10.1046/j.1468-2982.1994.1405352.x doi (DE-627)NLEJ238585603 DE-627 ger DE-627 rakwb D'Andrea, G verfasserin aut Decreased collagen-induced platelet aggregation and increased platelet arginine levels in migraine: a possible link with the NO pathway USA/Oxford, UK Blackwell Science Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| L-arginine Cananzi, AR verfasserin aut Perini, F verfasserin aut Alecci, M oth Zamberlan, F oth Hasselmark, L oth Welch, KMA oth In Cephalalgia London [u.a.] : Sage, 1981 14(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926839 (DE-600)2019999-5 1468-2982 nnns volume:14 year:1994 number:5 pages:0 http://dx.doi.org/10.1046/j.1468-2982.1994.1405352.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1994 5 0 |
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10.1046/j.1468-2982.1994.1405352.x doi (DE-627)NLEJ238585603 DE-627 ger DE-627 rakwb D'Andrea, G verfasserin aut Decreased collagen-induced platelet aggregation and increased platelet arginine levels in migraine: a possible link with the NO pathway USA/Oxford, UK Blackwell Science Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| L-arginine Cananzi, AR verfasserin aut Perini, F verfasserin aut Alecci, M oth Zamberlan, F oth Hasselmark, L oth Welch, KMA oth In Cephalalgia London [u.a.] : Sage, 1981 14(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926839 (DE-600)2019999-5 1468-2982 nnns volume:14 year:1994 number:5 pages:0 http://dx.doi.org/10.1046/j.1468-2982.1994.1405352.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1994 5 0 |
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10.1046/j.1468-2982.1994.1405352.x doi (DE-627)NLEJ238585603 DE-627 ger DE-627 rakwb D'Andrea, G verfasserin aut Decreased collagen-induced platelet aggregation and increased platelet arginine levels in migraine: a possible link with the NO pathway USA/Oxford, UK Blackwell Science Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| L-arginine Cananzi, AR verfasserin aut Perini, F verfasserin aut Alecci, M oth Zamberlan, F oth Hasselmark, L oth Welch, KMA oth In Cephalalgia London [u.a.] : Sage, 1981 14(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926839 (DE-600)2019999-5 1468-2982 nnns volume:14 year:1994 number:5 pages:0 http://dx.doi.org/10.1046/j.1468-2982.1994.1405352.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1994 5 0 |
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We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis. |
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We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis. |
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We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ238585603</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707064730.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120417s1994 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1468-2982.1994.1405352.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ238585603</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">D'Andrea, G</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Decreased collagen-induced platelet aggregation and increased platelet arginine levels in migraine: a possible link with the NO pathway</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">USA/Oxford, UK</subfield><subfield code="b">Blackwell Science Ltd</subfield><subfield code="c">1994</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">We studied whole blood platelet aggregation induced by collagen, platelet activating factor (PAF) and measured basal platelet L-arginine (L-arg) levels, as an indirect index of the nitric oxide (NO) pathway in migraine. Migraine, both with and without aura groups, showed a reduced aggregation to collagen, but not to PAF, compared with control subjects. Platelet L-arg levels were significantly increased in migraine with aura sufferers, whereas the plasma levels were in the same range in migraineurs and controls. Platelet hyperesponsiveness to collagen stimulation in migraine may be linked to an increased availability of the amino acid precursor and an abnormal NO synthesis.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2002</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2002||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">L-arginine</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cananzi, AR</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Perini, F</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alecci, M</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zamberlan, F</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hasselmark, L</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Welch, KMA</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Cephalalgia</subfield><subfield code="d">London [u.a.] : Sage, 1981</subfield><subfield code="g">14(1994), 5, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926839</subfield><subfield code="w">(DE-600)2019999-5</subfield><subfield code="x">1468-2982</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:14</subfield><subfield code="g">year:1994</subfield><subfield code="g">number:5</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1468-2982.1994.1405352.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">14</subfield><subfield code="j">1994</subfield><subfield code="e">5</subfield><subfield code="h">0</subfield></datafield></record></collection>
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