EFFECT OF THROMBIN AND PDGF ON ENDOTHELIN PRODUCTION IN CULTURED MESANGIAL CELLS DERIVED FROM SPONTANEOUSLY HYPERTENSIVE RATS
1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimu...
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E-Artikel |
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Oxford, UK: Blackwell Publishing Ltd ; 1995 |
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Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 22(1995), Seite 0 |
| Übergeordnetes Werk: |
volume:22 ; year:1995 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/j.1440-1681.1995.tb02879.x |
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| 520 | |a 1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimulated ET-1 production in a concentration-dependent manner in these cells of both rat strains, but thrombin- and PDGF-induced stimulation of ET-1 production were clearly greater in cells of SHR than WKY rats.3. The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.4. An inactive enantiomer of phorbol ester, 4a-PDD, had no effect on the ET-1 production in these cells of both rat strains.5. Neither thrombin nor PDGF stimulated ET-1 production in PKC-depleted cells of both rat strains. | ||
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10.1111/j.1440-1681.1995.tb02879.x doi (DE-627)NLEJ238597954 DE-627 ger DE-627 rakwb EFFECT OF THROMBIN AND PDGF ON ENDOTHELIN PRODUCTION IN CULTURED MESANGIAL CELLS DERIVED FROM SPONTANEOUSLY HYPERTENSIVE RATS Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimulated ET-1 production in a concentration-dependent manner in these cells of both rat strains, but thrombin- and PDGF-induced stimulation of ET-1 production were clearly greater in cells of SHR than WKY rats.3. The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.4. An inactive enantiomer of phorbol ester, 4a-PDD, had no effect on the ET-1 production in these cells of both rat strains.5. Neither thrombin nor PDGF stimulated ET-1 production in PKC-depleted cells of both rat strains. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| endothelin Ikeda, Miwako oth Kohno, Masakazu oth Horio, Takeshi oth Yasunari, Kenichi oth Yokokawa, Koji oth Kano, Hiroaki oth Minami, Mieko oth Hanehira, Takao oth Fukui, Toshiki oth Takeda, Tadanao oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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10.1111/j.1440-1681.1995.tb02879.x doi (DE-627)NLEJ238597954 DE-627 ger DE-627 rakwb EFFECT OF THROMBIN AND PDGF ON ENDOTHELIN PRODUCTION IN CULTURED MESANGIAL CELLS DERIVED FROM SPONTANEOUSLY HYPERTENSIVE RATS Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimulated ET-1 production in a concentration-dependent manner in these cells of both rat strains, but thrombin- and PDGF-induced stimulation of ET-1 production were clearly greater in cells of SHR than WKY rats.3. The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.4. An inactive enantiomer of phorbol ester, 4a-PDD, had no effect on the ET-1 production in these cells of both rat strains.5. Neither thrombin nor PDGF stimulated ET-1 production in PKC-depleted cells of both rat strains. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| endothelin Ikeda, Miwako oth Kohno, Masakazu oth Horio, Takeshi oth Yasunari, Kenichi oth Yokokawa, Koji oth Kano, Hiroaki oth Minami, Mieko oth Hanehira, Takao oth Fukui, Toshiki oth Takeda, Tadanao oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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10.1111/j.1440-1681.1995.tb02879.x doi (DE-627)NLEJ238597954 DE-627 ger DE-627 rakwb EFFECT OF THROMBIN AND PDGF ON ENDOTHELIN PRODUCTION IN CULTURED MESANGIAL CELLS DERIVED FROM SPONTANEOUSLY HYPERTENSIVE RATS Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimulated ET-1 production in a concentration-dependent manner in these cells of both rat strains, but thrombin- and PDGF-induced stimulation of ET-1 production were clearly greater in cells of SHR than WKY rats.3. The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.4. An inactive enantiomer of phorbol ester, 4a-PDD, had no effect on the ET-1 production in these cells of both rat strains.5. Neither thrombin nor PDGF stimulated ET-1 production in PKC-depleted cells of both rat strains. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| endothelin Ikeda, Miwako oth Kohno, Masakazu oth Horio, Takeshi oth Yasunari, Kenichi oth Yokokawa, Koji oth Kano, Hiroaki oth Minami, Mieko oth Hanehira, Takao oth Fukui, Toshiki oth Takeda, Tadanao oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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10.1111/j.1440-1681.1995.tb02879.x doi (DE-627)NLEJ238597954 DE-627 ger DE-627 rakwb EFFECT OF THROMBIN AND PDGF ON ENDOTHELIN PRODUCTION IN CULTURED MESANGIAL CELLS DERIVED FROM SPONTANEOUSLY HYPERTENSIVE RATS Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimulated ET-1 production in a concentration-dependent manner in these cells of both rat strains, but thrombin- and PDGF-induced stimulation of ET-1 production were clearly greater in cells of SHR than WKY rats.3. The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.4. An inactive enantiomer of phorbol ester, 4a-PDD, had no effect on the ET-1 production in these cells of both rat strains.5. Neither thrombin nor PDGF stimulated ET-1 production in PKC-depleted cells of both rat strains. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| endothelin Ikeda, Miwako oth Kohno, Masakazu oth Horio, Takeshi oth Yasunari, Kenichi oth Yokokawa, Koji oth Kano, Hiroaki oth Minami, Mieko oth Hanehira, Takao oth Fukui, Toshiki oth Takeda, Tadanao oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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10.1111/j.1440-1681.1995.tb02879.x doi (DE-627)NLEJ238597954 DE-627 ger DE-627 rakwb EFFECT OF THROMBIN AND PDGF ON ENDOTHELIN PRODUCTION IN CULTURED MESANGIAL CELLS DERIVED FROM SPONTANEOUSLY HYPERTENSIVE RATS Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimulated ET-1 production in a concentration-dependent manner in these cells of both rat strains, but thrombin- and PDGF-induced stimulation of ET-1 production were clearly greater in cells of SHR than WKY rats.3. The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.4. An inactive enantiomer of phorbol ester, 4a-PDD, had no effect on the ET-1 production in these cells of both rat strains.5. Neither thrombin nor PDGF stimulated ET-1 production in PKC-depleted cells of both rat strains. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| endothelin Ikeda, Miwako oth Kohno, Masakazu oth Horio, Takeshi oth Yasunari, Kenichi oth Yokokawa, Koji oth Kano, Hiroaki oth Minami, Mieko oth Hanehira, Takao oth Fukui, Toshiki oth Takeda, Tadanao oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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effect of thrombin and pdgf on endothelin production in cultured mesangial cells derived from spontaneously hypertensive rats |
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EFFECT OF THROMBIN AND PDGF ON ENDOTHELIN PRODUCTION IN CULTURED MESANGIAL CELLS DERIVED FROM SPONTANEOUSLY HYPERTENSIVE RATS |
| abstract |
1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimulated ET-1 production in a concentration-dependent manner in these cells of both rat strains, but thrombin- and PDGF-induced stimulation of ET-1 production were clearly greater in cells of SHR than WKY rats.3. The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.4. An inactive enantiomer of phorbol ester, 4a-PDD, had no effect on the ET-1 production in these cells of both rat strains.5. Neither thrombin nor PDGF stimulated ET-1 production in PKC-depleted cells of both rat strains. |
| abstractGer |
1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimulated ET-1 production in a concentration-dependent manner in these cells of both rat strains, but thrombin- and PDGF-induced stimulation of ET-1 production were clearly greater in cells of SHR than WKY rats.3. The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.4. An inactive enantiomer of phorbol ester, 4a-PDD, had no effect on the ET-1 production in these cells of both rat strains.5. Neither thrombin nor PDGF stimulated ET-1 production in PKC-depleted cells of both rat strains. |
| abstract_unstemmed |
1. Basal endothelin-1 (ET-1) production in mesangial cells of spontaneously hypertensive rats (SHR) was not different from that of Wistar-Kyoto (WKY) rats, although a trend toward increased ET-1 production was observed in these cells of SHR.2. Thrombin and platelet-derived growth factor (PDGF) stimulated ET-1 production in a concentration-dependent manner in these cells of both rat strains, but thrombin- and PDGF-induced stimulation of ET-1 production were clearly greater in cells of SHR than WKY rats.3. The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.4. An inactive enantiomer of phorbol ester, 4a-PDD, had no effect on the ET-1 production in these cells of both rat strains.5. Neither thrombin nor PDGF stimulated ET-1 production in PKC-depleted cells of both rat strains. |
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| title_short |
EFFECT OF THROMBIN AND PDGF ON ENDOTHELIN PRODUCTION IN CULTURED MESANGIAL CELLS DERIVED FROM SPONTANEOUSLY HYPERTENSIVE RATS |
| url |
http://dx.doi.org/10.1111/j.1440-1681.1995.tb02879.x |
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| author2 |
Ikeda, Miwako Kohno, Masakazu Horio, Takeshi Yasunari, Kenichi Yokokawa, Koji Kano, Hiroaki Minami, Mieko Hanehira, Takao Fukui, Toshiki Takeda, Tadanao |
| author2Str |
Ikeda, Miwako Kohno, Masakazu Horio, Takeshi Yasunari, Kenichi Yokokawa, Koji Kano, Hiroaki Minami, Mieko Hanehira, Takao Fukui, Toshiki Takeda, Tadanao |
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| doi_str |
10.1111/j.1440-1681.1995.tb02879.x |
| up_date |
2024-07-06T05:32:37.131Z |
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