EFFECTS OF CHRONIC TREATMENT WITH CARVEDILOL ON ABNORMALITIES OF ENDOTHELIUM-DEPENDENT RELAXATION AND STRUCTURE OF ENDOTHELIUM IN RESISTANCE ARTERIES OF SHRSP
1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sasaki, F. [verfasserIn] Yamamoto, K. [verfasserIn] Shimamura, K. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1995 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 22(1995), Seite 0 |
| Übergeordnetes Werk: |
volume:22 ; year:1995 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/j.1440-1681.1995.tb02940.x |
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| 520 | |a 1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2. Chronic treatment with carvedilol at a dose range of 30–120 mg/kg per day lowered systolic blood pressure of SHRSP from 234.9 ± 3.3 to 198.7 ± 3.1 mmHg at 16 weeks of age.3. Acetylcholine-induced endothelium-dependent relaxation was impaired in the mesenteric artery from SHRSP and high concentrations of acetylcholine produced contractions. The impairment of the relaxation was abolished in the presence of indomethacin. Carvedilol treatment improved the impairment in the preparation from SHRSP. The structural abnormality of endothelium was observed in the preparation from SHRSP. The abnormality could be prevented by the antihypertensive treatment.4. These results suggest that the impairment of endothelium-dependent relaxation in the preparation from SHRSP is due to the corelease of an endothelium-derived contracting factor which is considered to be a product of cyclo-oxygenase pathway of arachidonic acid cascade and that the impairment can be prevented by the antihypertensive treatment with carvedilol. | ||
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10.1111/j.1440-1681.1995.tb02940.x doi (DE-627)NLEJ23859856X DE-627 ger DE-627 rakwb Sasaki, F. verfasserin aut EFFECTS OF CHRONIC TREATMENT WITH CARVEDILOL ON ABNORMALITIES OF ENDOTHELIUM-DEPENDENT RELAXATION AND STRUCTURE OF ENDOTHELIUM IN RESISTANCE ARTERIES OF SHRSP Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2. Chronic treatment with carvedilol at a dose range of 30–120 mg/kg per day lowered systolic blood pressure of SHRSP from 234.9 ± 3.3 to 198.7 ± 3.1 mmHg at 16 weeks of age.3. Acetylcholine-induced endothelium-dependent relaxation was impaired in the mesenteric artery from SHRSP and high concentrations of acetylcholine produced contractions. The impairment of the relaxation was abolished in the presence of indomethacin. Carvedilol treatment improved the impairment in the preparation from SHRSP. The structural abnormality of endothelium was observed in the preparation from SHRSP. The abnormality could be prevented by the antihypertensive treatment.4. These results suggest that the impairment of endothelium-dependent relaxation in the preparation from SHRSP is due to the corelease of an endothelium-derived contracting factor which is considered to be a product of cyclo-oxygenase pathway of arachidonic acid cascade and that the impairment can be prevented by the antihypertensive treatment with carvedilol. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| carvedilol chronic treatment Yamamoto, K. verfasserin aut Shimamura, K. verfasserin aut Shibutani, T. oth Hashimoto, H. oth Tanaka, M. oth Sunano, S. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02940.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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10.1111/j.1440-1681.1995.tb02940.x doi (DE-627)NLEJ23859856X DE-627 ger DE-627 rakwb Sasaki, F. verfasserin aut EFFECTS OF CHRONIC TREATMENT WITH CARVEDILOL ON ABNORMALITIES OF ENDOTHELIUM-DEPENDENT RELAXATION AND STRUCTURE OF ENDOTHELIUM IN RESISTANCE ARTERIES OF SHRSP Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2. Chronic treatment with carvedilol at a dose range of 30–120 mg/kg per day lowered systolic blood pressure of SHRSP from 234.9 ± 3.3 to 198.7 ± 3.1 mmHg at 16 weeks of age.3. Acetylcholine-induced endothelium-dependent relaxation was impaired in the mesenteric artery from SHRSP and high concentrations of acetylcholine produced contractions. The impairment of the relaxation was abolished in the presence of indomethacin. Carvedilol treatment improved the impairment in the preparation from SHRSP. The structural abnormality of endothelium was observed in the preparation from SHRSP. The abnormality could be prevented by the antihypertensive treatment.4. These results suggest that the impairment of endothelium-dependent relaxation in the preparation from SHRSP is due to the corelease of an endothelium-derived contracting factor which is considered to be a product of cyclo-oxygenase pathway of arachidonic acid cascade and that the impairment can be prevented by the antihypertensive treatment with carvedilol. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| carvedilol chronic treatment Yamamoto, K. verfasserin aut Shimamura, K. verfasserin aut Shibutani, T. oth Hashimoto, H. oth Tanaka, M. oth Sunano, S. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02940.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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10.1111/j.1440-1681.1995.tb02940.x doi (DE-627)NLEJ23859856X DE-627 ger DE-627 rakwb Sasaki, F. verfasserin aut EFFECTS OF CHRONIC TREATMENT WITH CARVEDILOL ON ABNORMALITIES OF ENDOTHELIUM-DEPENDENT RELAXATION AND STRUCTURE OF ENDOTHELIUM IN RESISTANCE ARTERIES OF SHRSP Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2. Chronic treatment with carvedilol at a dose range of 30–120 mg/kg per day lowered systolic blood pressure of SHRSP from 234.9 ± 3.3 to 198.7 ± 3.1 mmHg at 16 weeks of age.3. Acetylcholine-induced endothelium-dependent relaxation was impaired in the mesenteric artery from SHRSP and high concentrations of acetylcholine produced contractions. The impairment of the relaxation was abolished in the presence of indomethacin. Carvedilol treatment improved the impairment in the preparation from SHRSP. The structural abnormality of endothelium was observed in the preparation from SHRSP. The abnormality could be prevented by the antihypertensive treatment.4. These results suggest that the impairment of endothelium-dependent relaxation in the preparation from SHRSP is due to the corelease of an endothelium-derived contracting factor which is considered to be a product of cyclo-oxygenase pathway of arachidonic acid cascade and that the impairment can be prevented by the antihypertensive treatment with carvedilol. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| carvedilol chronic treatment Yamamoto, K. verfasserin aut Shimamura, K. verfasserin aut Shibutani, T. oth Hashimoto, H. oth Tanaka, M. oth Sunano, S. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02940.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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10.1111/j.1440-1681.1995.tb02940.x doi (DE-627)NLEJ23859856X DE-627 ger DE-627 rakwb Sasaki, F. verfasserin aut EFFECTS OF CHRONIC TREATMENT WITH CARVEDILOL ON ABNORMALITIES OF ENDOTHELIUM-DEPENDENT RELAXATION AND STRUCTURE OF ENDOTHELIUM IN RESISTANCE ARTERIES OF SHRSP Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2. Chronic treatment with carvedilol at a dose range of 30–120 mg/kg per day lowered systolic blood pressure of SHRSP from 234.9 ± 3.3 to 198.7 ± 3.1 mmHg at 16 weeks of age.3. Acetylcholine-induced endothelium-dependent relaxation was impaired in the mesenteric artery from SHRSP and high concentrations of acetylcholine produced contractions. The impairment of the relaxation was abolished in the presence of indomethacin. Carvedilol treatment improved the impairment in the preparation from SHRSP. The structural abnormality of endothelium was observed in the preparation from SHRSP. The abnormality could be prevented by the antihypertensive treatment.4. These results suggest that the impairment of endothelium-dependent relaxation in the preparation from SHRSP is due to the corelease of an endothelium-derived contracting factor which is considered to be a product of cyclo-oxygenase pathway of arachidonic acid cascade and that the impairment can be prevented by the antihypertensive treatment with carvedilol. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| carvedilol chronic treatment Yamamoto, K. verfasserin aut Shimamura, K. verfasserin aut Shibutani, T. oth Hashimoto, H. oth Tanaka, M. oth Sunano, S. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02940.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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10.1111/j.1440-1681.1995.tb02940.x doi (DE-627)NLEJ23859856X DE-627 ger DE-627 rakwb Sasaki, F. verfasserin aut EFFECTS OF CHRONIC TREATMENT WITH CARVEDILOL ON ABNORMALITIES OF ENDOTHELIUM-DEPENDENT RELAXATION AND STRUCTURE OF ENDOTHELIUM IN RESISTANCE ARTERIES OF SHRSP Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2. Chronic treatment with carvedilol at a dose range of 30–120 mg/kg per day lowered systolic blood pressure of SHRSP from 234.9 ± 3.3 to 198.7 ± 3.1 mmHg at 16 weeks of age.3. Acetylcholine-induced endothelium-dependent relaxation was impaired in the mesenteric artery from SHRSP and high concentrations of acetylcholine produced contractions. The impairment of the relaxation was abolished in the presence of indomethacin. Carvedilol treatment improved the impairment in the preparation from SHRSP. The structural abnormality of endothelium was observed in the preparation from SHRSP. The abnormality could be prevented by the antihypertensive treatment.4. These results suggest that the impairment of endothelium-dependent relaxation in the preparation from SHRSP is due to the corelease of an endothelium-derived contracting factor which is considered to be a product of cyclo-oxygenase pathway of arachidonic acid cascade and that the impairment can be prevented by the antihypertensive treatment with carvedilol. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| carvedilol chronic treatment Yamamoto, K. verfasserin aut Shimamura, K. verfasserin aut Shibutani, T. oth Hashimoto, H. oth Tanaka, M. oth Sunano, S. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 22(1995), Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:22 year:1995 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1995.tb02940.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1995 0 |
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EFFECTS OF CHRONIC TREATMENT WITH CARVEDILOL ON ABNORMALITIES OF ENDOTHELIUM-DEPENDENT RELAXATION AND STRUCTURE OF ENDOTHELIUM IN RESISTANCE ARTERIES OF SHRSP |
| abstract |
1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2. Chronic treatment with carvedilol at a dose range of 30–120 mg/kg per day lowered systolic blood pressure of SHRSP from 234.9 ± 3.3 to 198.7 ± 3.1 mmHg at 16 weeks of age.3. Acetylcholine-induced endothelium-dependent relaxation was impaired in the mesenteric artery from SHRSP and high concentrations of acetylcholine produced contractions. The impairment of the relaxation was abolished in the presence of indomethacin. Carvedilol treatment improved the impairment in the preparation from SHRSP. The structural abnormality of endothelium was observed in the preparation from SHRSP. The abnormality could be prevented by the antihypertensive treatment.4. These results suggest that the impairment of endothelium-dependent relaxation in the preparation from SHRSP is due to the corelease of an endothelium-derived contracting factor which is considered to be a product of cyclo-oxygenase pathway of arachidonic acid cascade and that the impairment can be prevented by the antihypertensive treatment with carvedilol. |
| abstractGer |
1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2. Chronic treatment with carvedilol at a dose range of 30–120 mg/kg per day lowered systolic blood pressure of SHRSP from 234.9 ± 3.3 to 198.7 ± 3.1 mmHg at 16 weeks of age.3. Acetylcholine-induced endothelium-dependent relaxation was impaired in the mesenteric artery from SHRSP and high concentrations of acetylcholine produced contractions. The impairment of the relaxation was abolished in the presence of indomethacin. Carvedilol treatment improved the impairment in the preparation from SHRSP. The structural abnormality of endothelium was observed in the preparation from SHRSP. The abnormality could be prevented by the antihypertensive treatment.4. These results suggest that the impairment of endothelium-dependent relaxation in the preparation from SHRSP is due to the corelease of an endothelium-derived contracting factor which is considered to be a product of cyclo-oxygenase pathway of arachidonic acid cascade and that the impairment can be prevented by the antihypertensive treatment with carvedilol. |
| abstract_unstemmed |
1. This study investigated the effects of chronic treatment with carvedilol, a β-blocking agent with an α-blocking activity, on blood pressure, endothelium-dependent relaxation and the endothelial structure of the mesenteric resistance artery in stroke-prone spontaneously hypertensive rats (SHRSP).2. Chronic treatment with carvedilol at a dose range of 30–120 mg/kg per day lowered systolic blood pressure of SHRSP from 234.9 ± 3.3 to 198.7 ± 3.1 mmHg at 16 weeks of age.3. Acetylcholine-induced endothelium-dependent relaxation was impaired in the mesenteric artery from SHRSP and high concentrations of acetylcholine produced contractions. The impairment of the relaxation was abolished in the presence of indomethacin. Carvedilol treatment improved the impairment in the preparation from SHRSP. The structural abnormality of endothelium was observed in the preparation from SHRSP. The abnormality could be prevented by the antihypertensive treatment.4. These results suggest that the impairment of endothelium-dependent relaxation in the preparation from SHRSP is due to the corelease of an endothelium-derived contracting factor which is considered to be a product of cyclo-oxygenase pathway of arachidonic acid cascade and that the impairment can be prevented by the antihypertensive treatment with carvedilol. |
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| title_short |
EFFECTS OF CHRONIC TREATMENT WITH CARVEDILOL ON ABNORMALITIES OF ENDOTHELIUM-DEPENDENT RELAXATION AND STRUCTURE OF ENDOTHELIUM IN RESISTANCE ARTERIES OF SHRSP |
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Yamamoto, K. Shimamura, K. Shibutani, T. Hashimoto, H. Tanaka, M. Sunano, S. |
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| up_date |
2024-07-06T05:32:45.574Z |
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