EFFECTS OF CILAZAPRIL ON THE STRUCTURE OF MESENTERIC RESISTANCE ARTERIES OF NEW ZEALAND GENETICALLY HYPERTENSIVE AND NORMOTENSIVE CONTROL RATS

1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at t...
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Autor*in:	Ledingham, J. M. [verfasserIn] Phelan, E. L. [verfasserIn] Millar, J. A. [verfasserIn]

Format:	E-Artikel

Erschienen:	Oxford, UK: Blackwell Publishing Ltd ; 1993

Schlagwörter:	ACE inhibitors

Umfang:	Online-Ressource

Reproduktion:	2007 ; Blackwell Publishing Journal Backfiles 1879-2005
Übergeordnetes Werk:	In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 20(1993), 5, Seite 0
Übergeordnetes Werk:	volume:20 ; year:1993 ; number:5 ; pages:0

Links:	Volltext

DOI / URN:	10.1111/j.1440-1681.1993.tb01706.x

Katalog-ID:	NLEJ238603105

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520			\|a 1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at the end of the treatment period.3. The effect of cilazapril on the structure of mesenteric resistance arteries (MRA) was evaluated by both stereological and myographic techniques.4. Cilazapril lowered SBP significantly throughout the treatment period (16 weeks; GH with cilazapril 135 ± 5 vs GH 216 ± 9 mmHg, P < 0.001; N cilazapril 91 ± 6 vs N 137 ± 3 mmHg, P < 0.001); intra-arterial BP was also significantly lowered.5. Bodyweight (BW) of treated GH rats was significantly lower than that of untreated GH at 16 weeks (P < 0.01; t-test); however, the weight of treated N rats was not significantly affected. Ventricular mass was reduced by cilazapril in GH and N rats (GH 259 ± 10 vs 306 ± 11, P < 0.001; N 171 ± 3 vs 195 ± 4 mg/100g BW, P < 0.001).6. Lumen volume of MRA was not significantly affected by cilazapril in either strain; media volume was reduced by 14% in both strains and the media/lumen ratio was significantly reduced. Vascular smooth muscle cell density significantly increased in cilazapril-treated GH rats.
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allfields	10.1111/j.1440-1681.1993.tb01706.x doi (DE-627)NLEJ238603105 DE-627 ger DE-627 rakwb Ledingham, J. M. verfasserin aut EFFECTS OF CILAZAPRIL ON THE STRUCTURE OF MESENTERIC RESISTANCE ARTERIES OF NEW ZEALAND GENETICALLY HYPERTENSIVE AND NORMOTENSIVE CONTROL RATS Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at the end of the treatment period.3. The effect of cilazapril on the structure of mesenteric resistance arteries (MRA) was evaluated by both stereological and myographic techniques.4. Cilazapril lowered SBP significantly throughout the treatment period (16 weeks; GH with cilazapril 135 ± 5 vs GH 216 ± 9 mmHg, P < 0.001; N cilazapril 91 ± 6 vs N 137 ± 3 mmHg, P < 0.001); intra-arterial BP was also significantly lowered.5. Bodyweight (BW) of treated GH rats was significantly lower than that of untreated GH at 16 weeks (P < 0.01; t-test); however, the weight of treated N rats was not significantly affected. Ventricular mass was reduced by cilazapril in GH and N rats (GH 259 ± 10 vs 306 ± 11, P < 0.001; N 171 ± 3 vs 195 ± 4 mg/100g BW, P < 0.001).6. Lumen volume of MRA was not significantly affected by cilazapril in either strain; media volume was reduced by 14% in both strains and the media/lumen ratio was significantly reduced. Vascular smooth muscle cell density significantly increased in cilazapril-treated GH rats. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| ACE inhibitors Phelan, E. L. verfasserin aut Millar, J. A. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01706.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 5 0
spelling	10.1111/j.1440-1681.1993.tb01706.x doi (DE-627)NLEJ238603105 DE-627 ger DE-627 rakwb Ledingham, J. M. verfasserin aut EFFECTS OF CILAZAPRIL ON THE STRUCTURE OF MESENTERIC RESISTANCE ARTERIES OF NEW ZEALAND GENETICALLY HYPERTENSIVE AND NORMOTENSIVE CONTROL RATS Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at the end of the treatment period.3. The effect of cilazapril on the structure of mesenteric resistance arteries (MRA) was evaluated by both stereological and myographic techniques.4. Cilazapril lowered SBP significantly throughout the treatment period (16 weeks; GH with cilazapril 135 ± 5 vs GH 216 ± 9 mmHg, P < 0.001; N cilazapril 91 ± 6 vs N 137 ± 3 mmHg, P < 0.001); intra-arterial BP was also significantly lowered.5. Bodyweight (BW) of treated GH rats was significantly lower than that of untreated GH at 16 weeks (P < 0.01; t-test); however, the weight of treated N rats was not significantly affected. Ventricular mass was reduced by cilazapril in GH and N rats (GH 259 ± 10 vs 306 ± 11, P < 0.001; N 171 ± 3 vs 195 ± 4 mg/100g BW, P < 0.001).6. Lumen volume of MRA was not significantly affected by cilazapril in either strain; media volume was reduced by 14% in both strains and the media/lumen ratio was significantly reduced. Vascular smooth muscle cell density significantly increased in cilazapril-treated GH rats. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| ACE inhibitors Phelan, E. L. verfasserin aut Millar, J. A. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01706.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 5 0
allfields_unstemmed	10.1111/j.1440-1681.1993.tb01706.x doi (DE-627)NLEJ238603105 DE-627 ger DE-627 rakwb Ledingham, J. M. verfasserin aut EFFECTS OF CILAZAPRIL ON THE STRUCTURE OF MESENTERIC RESISTANCE ARTERIES OF NEW ZEALAND GENETICALLY HYPERTENSIVE AND NORMOTENSIVE CONTROL RATS Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at the end of the treatment period.3. The effect of cilazapril on the structure of mesenteric resistance arteries (MRA) was evaluated by both stereological and myographic techniques.4. Cilazapril lowered SBP significantly throughout the treatment period (16 weeks; GH with cilazapril 135 ± 5 vs GH 216 ± 9 mmHg, P < 0.001; N cilazapril 91 ± 6 vs N 137 ± 3 mmHg, P < 0.001); intra-arterial BP was also significantly lowered.5. Bodyweight (BW) of treated GH rats was significantly lower than that of untreated GH at 16 weeks (P < 0.01; t-test); however, the weight of treated N rats was not significantly affected. Ventricular mass was reduced by cilazapril in GH and N rats (GH 259 ± 10 vs 306 ± 11, P < 0.001; N 171 ± 3 vs 195 ± 4 mg/100g BW, P < 0.001).6. Lumen volume of MRA was not significantly affected by cilazapril in either strain; media volume was reduced by 14% in both strains and the media/lumen ratio was significantly reduced. Vascular smooth muscle cell density significantly increased in cilazapril-treated GH rats. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| ACE inhibitors Phelan, E. L. verfasserin aut Millar, J. A. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01706.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 5 0
allfieldsGer	10.1111/j.1440-1681.1993.tb01706.x doi (DE-627)NLEJ238603105 DE-627 ger DE-627 rakwb Ledingham, J. M. verfasserin aut EFFECTS OF CILAZAPRIL ON THE STRUCTURE OF MESENTERIC RESISTANCE ARTERIES OF NEW ZEALAND GENETICALLY HYPERTENSIVE AND NORMOTENSIVE CONTROL RATS Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at the end of the treatment period.3. The effect of cilazapril on the structure of mesenteric resistance arteries (MRA) was evaluated by both stereological and myographic techniques.4. Cilazapril lowered SBP significantly throughout the treatment period (16 weeks; GH with cilazapril 135 ± 5 vs GH 216 ± 9 mmHg, P < 0.001; N cilazapril 91 ± 6 vs N 137 ± 3 mmHg, P < 0.001); intra-arterial BP was also significantly lowered.5. Bodyweight (BW) of treated GH rats was significantly lower than that of untreated GH at 16 weeks (P < 0.01; t-test); however, the weight of treated N rats was not significantly affected. Ventricular mass was reduced by cilazapril in GH and N rats (GH 259 ± 10 vs 306 ± 11, P < 0.001; N 171 ± 3 vs 195 ± 4 mg/100g BW, P < 0.001).6. Lumen volume of MRA was not significantly affected by cilazapril in either strain; media volume was reduced by 14% in both strains and the media/lumen ratio was significantly reduced. Vascular smooth muscle cell density significantly increased in cilazapril-treated GH rats. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| ACE inhibitors Phelan, E. L. verfasserin aut Millar, J. A. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01706.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 5 0
allfieldsSound	10.1111/j.1440-1681.1993.tb01706.x doi (DE-627)NLEJ238603105 DE-627 ger DE-627 rakwb Ledingham, J. M. verfasserin aut EFFECTS OF CILAZAPRIL ON THE STRUCTURE OF MESENTERIC RESISTANCE ARTERIES OF NEW ZEALAND GENETICALLY HYPERTENSIVE AND NORMOTENSIVE CONTROL RATS Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at the end of the treatment period.3. The effect of cilazapril on the structure of mesenteric resistance arteries (MRA) was evaluated by both stereological and myographic techniques.4. Cilazapril lowered SBP significantly throughout the treatment period (16 weeks; GH with cilazapril 135 ± 5 vs GH 216 ± 9 mmHg, P < 0.001; N cilazapril 91 ± 6 vs N 137 ± 3 mmHg, P < 0.001); intra-arterial BP was also significantly lowered.5. Bodyweight (BW) of treated GH rats was significantly lower than that of untreated GH at 16 weeks (P < 0.01; t-test); however, the weight of treated N rats was not significantly affected. Ventricular mass was reduced by cilazapril in GH and N rats (GH 259 ± 10 vs 306 ± 11, P < 0.001; N 171 ± 3 vs 195 ± 4 mg/100g BW, P < 0.001).6. Lumen volume of MRA was not significantly affected by cilazapril in either strain; media volume was reduced by 14% in both strains and the media/lumen ratio was significantly reduced. Vascular smooth muscle cell density significantly increased in cilazapril-treated GH rats. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| ACE inhibitors Phelan, E. L. verfasserin aut Millar, J. A. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01706.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 5 0
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title_sort	effects of cilazapril on the structure of mesenteric resistance arteries of new zealand genetically hypertensive and normotensive control rats
title_auth	EFFECTS OF CILAZAPRIL ON THE STRUCTURE OF MESENTERIC RESISTANCE ARTERIES OF NEW ZEALAND GENETICALLY HYPERTENSIVE AND NORMOTENSIVE CONTROL RATS
abstract	1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at the end of the treatment period.3. The effect of cilazapril on the structure of mesenteric resistance arteries (MRA) was evaluated by both stereological and myographic techniques.4. Cilazapril lowered SBP significantly throughout the treatment period (16 weeks; GH with cilazapril 135 ± 5 vs GH 216 ± 9 mmHg, P < 0.001; N cilazapril 91 ± 6 vs N 137 ± 3 mmHg, P < 0.001); intra-arterial BP was also significantly lowered.5. Bodyweight (BW) of treated GH rats was significantly lower than that of untreated GH at 16 weeks (P < 0.01; t-test); however, the weight of treated N rats was not significantly affected. Ventricular mass was reduced by cilazapril in GH and N rats (GH 259 ± 10 vs 306 ± 11, P < 0.001; N 171 ± 3 vs 195 ± 4 mg/100g BW, P < 0.001).6. Lumen volume of MRA was not significantly affected by cilazapril in either strain; media volume was reduced by 14% in both strains and the media/lumen ratio was significantly reduced. Vascular smooth muscle cell density significantly increased in cilazapril-treated GH rats.
abstractGer	1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at the end of the treatment period.3. The effect of cilazapril on the structure of mesenteric resistance arteries (MRA) was evaluated by both stereological and myographic techniques.4. Cilazapril lowered SBP significantly throughout the treatment period (16 weeks; GH with cilazapril 135 ± 5 vs GH 216 ± 9 mmHg, P < 0.001; N cilazapril 91 ± 6 vs N 137 ± 3 mmHg, P < 0.001); intra-arterial BP was also significantly lowered.5. Bodyweight (BW) of treated GH rats was significantly lower than that of untreated GH at 16 weeks (P < 0.01; t-test); however, the weight of treated N rats was not significantly affected. Ventricular mass was reduced by cilazapril in GH and N rats (GH 259 ± 10 vs 306 ± 11, P < 0.001; N 171 ± 3 vs 195 ± 4 mg/100g BW, P < 0.001).6. Lumen volume of MRA was not significantly affected by cilazapril in either strain; media volume was reduced by 14% in both strains and the media/lumen ratio was significantly reduced. Vascular smooth muscle cell density significantly increased in cilazapril-treated GH rats.
abstract_unstemmed	1. New Zealand genetically hypertensive (GH) rats and their normotensive controls (N) rats between the ages of 10 and 16 weeks were treated with cilazapril in the diet for 6 weeks.2. Systolic blood pressure (SBP; tail-cuff) was measured weekly and intra-arterial blood pressure (BP) was measured at the end of the treatment period.3. The effect of cilazapril on the structure of mesenteric resistance arteries (MRA) was evaluated by both stereological and myographic techniques.4. Cilazapril lowered SBP significantly throughout the treatment period (16 weeks; GH with cilazapril 135 ± 5 vs GH 216 ± 9 mmHg, P < 0.001; N cilazapril 91 ± 6 vs N 137 ± 3 mmHg, P < 0.001); intra-arterial BP was also significantly lowered.5. Bodyweight (BW) of treated GH rats was significantly lower than that of untreated GH at 16 weeks (P < 0.01; t-test); however, the weight of treated N rats was not significantly affected. Ventricular mass was reduced by cilazapril in GH and N rats (GH 259 ± 10 vs 306 ± 11, P < 0.001; N 171 ± 3 vs 195 ± 4 mg/100g BW, P < 0.001).6. Lumen volume of MRA was not significantly affected by cilazapril in either strain; media volume was reduced by 14% in both strains and the media/lumen ratio was significantly reduced. Vascular smooth muscle cell density significantly increased in cilazapril-treated GH rats.
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container_issue	5
title_short	EFFECTS OF CILAZAPRIL ON THE STRUCTURE OF MESENTERIC RESISTANCE ARTERIES OF NEW ZEALAND GENETICALLY HYPERTENSIVE AND NORMOTENSIVE CONTROL RATS
url	http://dx.doi.org/10.1111/j.1440-1681.1993.tb01706.x
remote_bool	true
author2	Phelan, E. L. Millar, J. A.
author2Str	Phelan, E. L. Millar, J. A.
ppnlink	NLEJ243927150
mediatype_str_mv	z
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1111/j.1440-1681.1993.tb01706.x
up_date	2024-07-06T05:33:44.209Z
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