RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA-PIG TRACHEAL SMOOTH MUSCLE
1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induce...
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| Autor*in: |
Takagi, Kenzo [verfasserIn] Araki, Nobuyasu [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1993 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 20(1993), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:20 ; year:1993 ; number:4 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/j.1440-1681.1993.tb01676.x |
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NLEJ238603253 |
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| 520 | |a 1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induced contraction of tracheal smooth muscle with EC50 values of 3.1± 0.7 ± 10−8, 3.9 ± 1.0 ± 10−8 and 3.5 ± 1.0 ± 10−8 mol/L, respectively.3. BNP increased tissue cyclic GMP levels in tracheal smooth muscle concentration dependently (187 ± 26 fmol/mg protein in control, 334 ± 77 fmol/mg protein at 10−8 mol/L, 680 ± 54 fmol/mg protein at 10−7 mol/L, 2162 ± 133 fmol/mg protein at 10−6 mol/L).4. With the addition of BNP, tissue cyclic GMP levels reached a maximum at 1–3 min. The relaxation of tracheal smooth muscle began at 1 min and reached a maximum level at 5 min after the superfusion of BNP (10−6 mol/L). The elevation of cyclic GMP preceded the relaxation of tracheal smooth muscle.5. These results suggest that BNP may have a potent relaxant effect on tracheal smooth muscle and this effect may be mediated by cyclic GMP level. | ||
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10.1111/j.1440-1681.1993.tb01676.x doi (DE-627)NLEJ238603253 DE-627 ger DE-627 rakwb Takagi, Kenzo verfasserin aut RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA-PIG TRACHEAL SMOOTH MUSCLE Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induced contraction of tracheal smooth muscle with EC50 values of 3.1± 0.7 ± 10−8, 3.9 ± 1.0 ± 10−8 and 3.5 ± 1.0 ± 10−8 mol/L, respectively.3. BNP increased tissue cyclic GMP levels in tracheal smooth muscle concentration dependently (187 ± 26 fmol/mg protein in control, 334 ± 77 fmol/mg protein at 10−8 mol/L, 680 ± 54 fmol/mg protein at 10−7 mol/L, 2162 ± 133 fmol/mg protein at 10−6 mol/L).4. With the addition of BNP, tissue cyclic GMP levels reached a maximum at 1–3 min. The relaxation of tracheal smooth muscle began at 1 min and reached a maximum level at 5 min after the superfusion of BNP (10−6 mol/L). The elevation of cyclic GMP preceded the relaxation of tracheal smooth muscle.5. These results suggest that BNP may have a potent relaxant effect on tracheal smooth muscle and this effect may be mediated by cyclic GMP level. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| brain natriuretic peptide Araki, Nobuyasu verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:4 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01676.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 4 0 |
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10.1111/j.1440-1681.1993.tb01676.x doi (DE-627)NLEJ238603253 DE-627 ger DE-627 rakwb Takagi, Kenzo verfasserin aut RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA-PIG TRACHEAL SMOOTH MUSCLE Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induced contraction of tracheal smooth muscle with EC50 values of 3.1± 0.7 ± 10−8, 3.9 ± 1.0 ± 10−8 and 3.5 ± 1.0 ± 10−8 mol/L, respectively.3. BNP increased tissue cyclic GMP levels in tracheal smooth muscle concentration dependently (187 ± 26 fmol/mg protein in control, 334 ± 77 fmol/mg protein at 10−8 mol/L, 680 ± 54 fmol/mg protein at 10−7 mol/L, 2162 ± 133 fmol/mg protein at 10−6 mol/L).4. With the addition of BNP, tissue cyclic GMP levels reached a maximum at 1–3 min. The relaxation of tracheal smooth muscle began at 1 min and reached a maximum level at 5 min after the superfusion of BNP (10−6 mol/L). The elevation of cyclic GMP preceded the relaxation of tracheal smooth muscle.5. These results suggest that BNP may have a potent relaxant effect on tracheal smooth muscle and this effect may be mediated by cyclic GMP level. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| brain natriuretic peptide Araki, Nobuyasu verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:4 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01676.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 4 0 |
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10.1111/j.1440-1681.1993.tb01676.x doi (DE-627)NLEJ238603253 DE-627 ger DE-627 rakwb Takagi, Kenzo verfasserin aut RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA-PIG TRACHEAL SMOOTH MUSCLE Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induced contraction of tracheal smooth muscle with EC50 values of 3.1± 0.7 ± 10−8, 3.9 ± 1.0 ± 10−8 and 3.5 ± 1.0 ± 10−8 mol/L, respectively.3. BNP increased tissue cyclic GMP levels in tracheal smooth muscle concentration dependently (187 ± 26 fmol/mg protein in control, 334 ± 77 fmol/mg protein at 10−8 mol/L, 680 ± 54 fmol/mg protein at 10−7 mol/L, 2162 ± 133 fmol/mg protein at 10−6 mol/L).4. With the addition of BNP, tissue cyclic GMP levels reached a maximum at 1–3 min. The relaxation of tracheal smooth muscle began at 1 min and reached a maximum level at 5 min after the superfusion of BNP (10−6 mol/L). The elevation of cyclic GMP preceded the relaxation of tracheal smooth muscle.5. These results suggest that BNP may have a potent relaxant effect on tracheal smooth muscle and this effect may be mediated by cyclic GMP level. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| brain natriuretic peptide Araki, Nobuyasu verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:4 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01676.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 4 0 |
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10.1111/j.1440-1681.1993.tb01676.x doi (DE-627)NLEJ238603253 DE-627 ger DE-627 rakwb Takagi, Kenzo verfasserin aut RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA-PIG TRACHEAL SMOOTH MUSCLE Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induced contraction of tracheal smooth muscle with EC50 values of 3.1± 0.7 ± 10−8, 3.9 ± 1.0 ± 10−8 and 3.5 ± 1.0 ± 10−8 mol/L, respectively.3. BNP increased tissue cyclic GMP levels in tracheal smooth muscle concentration dependently (187 ± 26 fmol/mg protein in control, 334 ± 77 fmol/mg protein at 10−8 mol/L, 680 ± 54 fmol/mg protein at 10−7 mol/L, 2162 ± 133 fmol/mg protein at 10−6 mol/L).4. With the addition of BNP, tissue cyclic GMP levels reached a maximum at 1–3 min. The relaxation of tracheal smooth muscle began at 1 min and reached a maximum level at 5 min after the superfusion of BNP (10−6 mol/L). The elevation of cyclic GMP preceded the relaxation of tracheal smooth muscle.5. These results suggest that BNP may have a potent relaxant effect on tracheal smooth muscle and this effect may be mediated by cyclic GMP level. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| brain natriuretic peptide Araki, Nobuyasu verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:4 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01676.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 4 0 |
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10.1111/j.1440-1681.1993.tb01676.x doi (DE-627)NLEJ238603253 DE-627 ger DE-627 rakwb Takagi, Kenzo verfasserin aut RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA-PIG TRACHEAL SMOOTH MUSCLE Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induced contraction of tracheal smooth muscle with EC50 values of 3.1± 0.7 ± 10−8, 3.9 ± 1.0 ± 10−8 and 3.5 ± 1.0 ± 10−8 mol/L, respectively.3. BNP increased tissue cyclic GMP levels in tracheal smooth muscle concentration dependently (187 ± 26 fmol/mg protein in control, 334 ± 77 fmol/mg protein at 10−8 mol/L, 680 ± 54 fmol/mg protein at 10−7 mol/L, 2162 ± 133 fmol/mg protein at 10−6 mol/L).4. With the addition of BNP, tissue cyclic GMP levels reached a maximum at 1–3 min. The relaxation of tracheal smooth muscle began at 1 min and reached a maximum level at 5 min after the superfusion of BNP (10−6 mol/L). The elevation of cyclic GMP preceded the relaxation of tracheal smooth muscle.5. These results suggest that BNP may have a potent relaxant effect on tracheal smooth muscle and this effect may be mediated by cyclic GMP level. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| brain natriuretic peptide Araki, Nobuyasu verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 20(1993), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:20 year:1993 number:4 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1993.tb01676.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1993 4 0 |
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RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA-PIG TRACHEAL SMOOTH MUSCLE |
| abstract |
1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induced contraction of tracheal smooth muscle with EC50 values of 3.1± 0.7 ± 10−8, 3.9 ± 1.0 ± 10−8 and 3.5 ± 1.0 ± 10−8 mol/L, respectively.3. BNP increased tissue cyclic GMP levels in tracheal smooth muscle concentration dependently (187 ± 26 fmol/mg protein in control, 334 ± 77 fmol/mg protein at 10−8 mol/L, 680 ± 54 fmol/mg protein at 10−7 mol/L, 2162 ± 133 fmol/mg protein at 10−6 mol/L).4. With the addition of BNP, tissue cyclic GMP levels reached a maximum at 1–3 min. The relaxation of tracheal smooth muscle began at 1 min and reached a maximum level at 5 min after the superfusion of BNP (10−6 mol/L). The elevation of cyclic GMP preceded the relaxation of tracheal smooth muscle.5. These results suggest that BNP may have a potent relaxant effect on tracheal smooth muscle and this effect may be mediated by cyclic GMP level. |
| abstractGer |
1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induced contraction of tracheal smooth muscle with EC50 values of 3.1± 0.7 ± 10−8, 3.9 ± 1.0 ± 10−8 and 3.5 ± 1.0 ± 10−8 mol/L, respectively.3. BNP increased tissue cyclic GMP levels in tracheal smooth muscle concentration dependently (187 ± 26 fmol/mg protein in control, 334 ± 77 fmol/mg protein at 10−8 mol/L, 680 ± 54 fmol/mg protein at 10−7 mol/L, 2162 ± 133 fmol/mg protein at 10−6 mol/L).4. With the addition of BNP, tissue cyclic GMP levels reached a maximum at 1–3 min. The relaxation of tracheal smooth muscle began at 1 min and reached a maximum level at 5 min after the superfusion of BNP (10−6 mol/L). The elevation of cyclic GMP preceded the relaxation of tracheal smooth muscle.5. These results suggest that BNP may have a potent relaxant effect on tracheal smooth muscle and this effect may be mediated by cyclic GMP level. |
| abstract_unstemmed |
1. The relaxant effects of brain natriuretic peptide (BNP) were investigated on guinea-pig tracheal smooth muscle.2. Various amounts of BNP (10−9– 10−6 mol/L) showed concentration-dependent relaxant effects on resting tone, leukotriene D4 (LTD4; 10−8 mol/L) and endothelin-1 (ET-1; 10−8 mol/L) induced contraction of tracheal smooth muscle with EC50 values of 3.1± 0.7 ± 10−8, 3.9 ± 1.0 ± 10−8 and 3.5 ± 1.0 ± 10−8 mol/L, respectively.3. BNP increased tissue cyclic GMP levels in tracheal smooth muscle concentration dependently (187 ± 26 fmol/mg protein in control, 334 ± 77 fmol/mg protein at 10−8 mol/L, 680 ± 54 fmol/mg protein at 10−7 mol/L, 2162 ± 133 fmol/mg protein at 10−6 mol/L).4. With the addition of BNP, tissue cyclic GMP levels reached a maximum at 1–3 min. The relaxation of tracheal smooth muscle began at 1 min and reached a maximum level at 5 min after the superfusion of BNP (10−6 mol/L). The elevation of cyclic GMP preceded the relaxation of tracheal smooth muscle.5. These results suggest that BNP may have a potent relaxant effect on tracheal smooth muscle and this effect may be mediated by cyclic GMP level. |
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RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA-PIG TRACHEAL SMOOTH MUSCLE |
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