EFFECTS OF THE OPIOID PEPTIDES [MET5]ENKEPHALIN-ARG6-PHE7 AND [MET5]ENKEPHALIN-ARG6-GLY7-LEU8 ON CHOLINERGIC NEUROTRANSMISSION IN THE RABBIT ISOLATED ATRIA
1. The effect of the opioid peptides [Met5]enkephalin-Arg6-Phe7 (MEAP) and [Met5]enkephalin-Arg6-Gly7-Leu8 (MEAGL) were compared with those of [Leu5]enkephalin and [d-Ala2, Met5]enkephalinamide (DAME) on cholinergic neuro-transmission in the rabbit isolated atria.2. Rabbit isolated atria had a resti...
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| Autor*in: |
Wong-Dusting, H. [verfasserIn] Rand, M. J. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1987 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 14(1987), 9, Seite 0 |
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volume:14 ; year:1987 ; number:9 ; pages:0 |
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| DOI / URN: |
10.1111/j.1440-1681.1987.tb01897.x |
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10.1111/j.1440-1681.1987.tb01897.x doi (DE-627)NLEJ238611272 DE-627 ger DE-627 rakwb Wong-Dusting, H. verfasserin aut EFFECTS OF THE OPIOID PEPTIDES [MET5]ENKEPHALIN-ARG6-PHE7 AND [MET5]ENKEPHALIN-ARG6-GLY7-LEU8 ON CHOLINERGIC NEUROTRANSMISSION IN THE RABBIT ISOLATED ATRIA Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of the opioid peptides [Met5]enkephalin-Arg6-Phe7 (MEAP) and [Met5]enkephalin-Arg6-Gly7-Leu8 (MEAGL) were compared with those of [Leu5]enkephalin and [d-Ala2, Met5]enkephalinamide (DAME) on cholinergic neuro-transmission in the rabbit isolated atria.2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of the β-adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field stimulation with a cholinergically mediated negative chronotropic response. The opioid peptides had no effect on the resting rate, but inhibited the negative chronotropic response to field stimulation. The IC50 values for inhibiting the cholinergic responses were 1.4 μmol/l for [Leu5]enkephalin (LE), 1.4 μmol/l for MEAP, 1.3 μmol/l for MEAGL and 0.2 μmol/l for DAME. Responses of a similar magnitude to exogenous acetylcholine were unaffected.3. Thus, MEAP, MEAGL and LE had similar potencies but DAME was about seven times more potent in inhibiting cholinergic neurotransmission in the rabbit isolated atria. The site of inhibition appears to be prejunctional. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| cholinergic neurotransmission Rand, M. J. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 14(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:14 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1987 9 0 |
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10.1111/j.1440-1681.1987.tb01897.x doi (DE-627)NLEJ238611272 DE-627 ger DE-627 rakwb Wong-Dusting, H. verfasserin aut EFFECTS OF THE OPIOID PEPTIDES [MET5]ENKEPHALIN-ARG6-PHE7 AND [MET5]ENKEPHALIN-ARG6-GLY7-LEU8 ON CHOLINERGIC NEUROTRANSMISSION IN THE RABBIT ISOLATED ATRIA Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of the opioid peptides [Met5]enkephalin-Arg6-Phe7 (MEAP) and [Met5]enkephalin-Arg6-Gly7-Leu8 (MEAGL) were compared with those of [Leu5]enkephalin and [d-Ala2, Met5]enkephalinamide (DAME) on cholinergic neuro-transmission in the rabbit isolated atria.2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of the β-adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field stimulation with a cholinergically mediated negative chronotropic response. The opioid peptides had no effect on the resting rate, but inhibited the negative chronotropic response to field stimulation. The IC50 values for inhibiting the cholinergic responses were 1.4 μmol/l for [Leu5]enkephalin (LE), 1.4 μmol/l for MEAP, 1.3 μmol/l for MEAGL and 0.2 μmol/l for DAME. Responses of a similar magnitude to exogenous acetylcholine were unaffected.3. Thus, MEAP, MEAGL and LE had similar potencies but DAME was about seven times more potent in inhibiting cholinergic neurotransmission in the rabbit isolated atria. The site of inhibition appears to be prejunctional. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| cholinergic neurotransmission Rand, M. J. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 14(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:14 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1987 9 0 |
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10.1111/j.1440-1681.1987.tb01897.x doi (DE-627)NLEJ238611272 DE-627 ger DE-627 rakwb Wong-Dusting, H. verfasserin aut EFFECTS OF THE OPIOID PEPTIDES [MET5]ENKEPHALIN-ARG6-PHE7 AND [MET5]ENKEPHALIN-ARG6-GLY7-LEU8 ON CHOLINERGIC NEUROTRANSMISSION IN THE RABBIT ISOLATED ATRIA Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of the opioid peptides [Met5]enkephalin-Arg6-Phe7 (MEAP) and [Met5]enkephalin-Arg6-Gly7-Leu8 (MEAGL) were compared with those of [Leu5]enkephalin and [d-Ala2, Met5]enkephalinamide (DAME) on cholinergic neuro-transmission in the rabbit isolated atria.2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of the β-adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field stimulation with a cholinergically mediated negative chronotropic response. The opioid peptides had no effect on the resting rate, but inhibited the negative chronotropic response to field stimulation. The IC50 values for inhibiting the cholinergic responses were 1.4 μmol/l for [Leu5]enkephalin (LE), 1.4 μmol/l for MEAP, 1.3 μmol/l for MEAGL and 0.2 μmol/l for DAME. Responses of a similar magnitude to exogenous acetylcholine were unaffected.3. Thus, MEAP, MEAGL and LE had similar potencies but DAME was about seven times more potent in inhibiting cholinergic neurotransmission in the rabbit isolated atria. The site of inhibition appears to be prejunctional. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| cholinergic neurotransmission Rand, M. J. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 14(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:14 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1987 9 0 |
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10.1111/j.1440-1681.1987.tb01897.x doi (DE-627)NLEJ238611272 DE-627 ger DE-627 rakwb Wong-Dusting, H. verfasserin aut EFFECTS OF THE OPIOID PEPTIDES [MET5]ENKEPHALIN-ARG6-PHE7 AND [MET5]ENKEPHALIN-ARG6-GLY7-LEU8 ON CHOLINERGIC NEUROTRANSMISSION IN THE RABBIT ISOLATED ATRIA Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of the opioid peptides [Met5]enkephalin-Arg6-Phe7 (MEAP) and [Met5]enkephalin-Arg6-Gly7-Leu8 (MEAGL) were compared with those of [Leu5]enkephalin and [d-Ala2, Met5]enkephalinamide (DAME) on cholinergic neuro-transmission in the rabbit isolated atria.2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of the β-adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field stimulation with a cholinergically mediated negative chronotropic response. The opioid peptides had no effect on the resting rate, but inhibited the negative chronotropic response to field stimulation. The IC50 values for inhibiting the cholinergic responses were 1.4 μmol/l for [Leu5]enkephalin (LE), 1.4 μmol/l for MEAP, 1.3 μmol/l for MEAGL and 0.2 μmol/l for DAME. Responses of a similar magnitude to exogenous acetylcholine were unaffected.3. Thus, MEAP, MEAGL and LE had similar potencies but DAME was about seven times more potent in inhibiting cholinergic neurotransmission in the rabbit isolated atria. The site of inhibition appears to be prejunctional. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| cholinergic neurotransmission Rand, M. J. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 14(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:14 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1987 9 0 |
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10.1111/j.1440-1681.1987.tb01897.x doi (DE-627)NLEJ238611272 DE-627 ger DE-627 rakwb Wong-Dusting, H. verfasserin aut EFFECTS OF THE OPIOID PEPTIDES [MET5]ENKEPHALIN-ARG6-PHE7 AND [MET5]ENKEPHALIN-ARG6-GLY7-LEU8 ON CHOLINERGIC NEUROTRANSMISSION IN THE RABBIT ISOLATED ATRIA Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of the opioid peptides [Met5]enkephalin-Arg6-Phe7 (MEAP) and [Met5]enkephalin-Arg6-Gly7-Leu8 (MEAGL) were compared with those of [Leu5]enkephalin and [d-Ala2, Met5]enkephalinamide (DAME) on cholinergic neuro-transmission in the rabbit isolated atria.2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of the β-adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field stimulation with a cholinergically mediated negative chronotropic response. The opioid peptides had no effect on the resting rate, but inhibited the negative chronotropic response to field stimulation. The IC50 values for inhibiting the cholinergic responses were 1.4 μmol/l for [Leu5]enkephalin (LE), 1.4 μmol/l for MEAP, 1.3 μmol/l for MEAGL and 0.2 μmol/l for DAME. Responses of a similar magnitude to exogenous acetylcholine were unaffected.3. Thus, MEAP, MEAGL and LE had similar potencies but DAME was about seven times more potent in inhibiting cholinergic neurotransmission in the rabbit isolated atria. The site of inhibition appears to be prejunctional. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| cholinergic neurotransmission Rand, M. J. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 14(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:14 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 1987 9 0 |
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effects of the opioid peptides [met5]enkephalin-arg6-phe7 and [met5]enkephalin-arg6-gly7-leu8 on cholinergic neurotransmission in the rabbit isolated atria |
| title_auth |
EFFECTS OF THE OPIOID PEPTIDES [MET5]ENKEPHALIN-ARG6-PHE7 AND [MET5]ENKEPHALIN-ARG6-GLY7-LEU8 ON CHOLINERGIC NEUROTRANSMISSION IN THE RABBIT ISOLATED ATRIA |
| abstract |
1. The effect of the opioid peptides [Met5]enkephalin-Arg6-Phe7 (MEAP) and [Met5]enkephalin-Arg6-Gly7-Leu8 (MEAGL) were compared with those of [Leu5]enkephalin and [d-Ala2, Met5]enkephalinamide (DAME) on cholinergic neuro-transmission in the rabbit isolated atria.2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of the β-adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field stimulation with a cholinergically mediated negative chronotropic response. The opioid peptides had no effect on the resting rate, but inhibited the negative chronotropic response to field stimulation. The IC50 values for inhibiting the cholinergic responses were 1.4 μmol/l for [Leu5]enkephalin (LE), 1.4 μmol/l for MEAP, 1.3 μmol/l for MEAGL and 0.2 μmol/l for DAME. Responses of a similar magnitude to exogenous acetylcholine were unaffected.3. Thus, MEAP, MEAGL and LE had similar potencies but DAME was about seven times more potent in inhibiting cholinergic neurotransmission in the rabbit isolated atria. The site of inhibition appears to be prejunctional. |
| abstractGer |
1. The effect of the opioid peptides [Met5]enkephalin-Arg6-Phe7 (MEAP) and [Met5]enkephalin-Arg6-Gly7-Leu8 (MEAGL) were compared with those of [Leu5]enkephalin and [d-Ala2, Met5]enkephalinamide (DAME) on cholinergic neuro-transmission in the rabbit isolated atria.2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of the β-adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field stimulation with a cholinergically mediated negative chronotropic response. The opioid peptides had no effect on the resting rate, but inhibited the negative chronotropic response to field stimulation. The IC50 values for inhibiting the cholinergic responses were 1.4 μmol/l for [Leu5]enkephalin (LE), 1.4 μmol/l for MEAP, 1.3 μmol/l for MEAGL and 0.2 μmol/l for DAME. Responses of a similar magnitude to exogenous acetylcholine were unaffected.3. Thus, MEAP, MEAGL and LE had similar potencies but DAME was about seven times more potent in inhibiting cholinergic neurotransmission in the rabbit isolated atria. The site of inhibition appears to be prejunctional. |
| abstract_unstemmed |
1. The effect of the opioid peptides [Met5]enkephalin-Arg6-Phe7 (MEAP) and [Met5]enkephalin-Arg6-Gly7-Leu8 (MEAGL) were compared with those of [Leu5]enkephalin and [d-Ala2, Met5]enkephalinamide (DAME) on cholinergic neuro-transmission in the rabbit isolated atria.2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of the β-adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field stimulation with a cholinergically mediated negative chronotropic response. The opioid peptides had no effect on the resting rate, but inhibited the negative chronotropic response to field stimulation. The IC50 values for inhibiting the cholinergic responses were 1.4 μmol/l for [Leu5]enkephalin (LE), 1.4 μmol/l for MEAP, 1.3 μmol/l for MEAGL and 0.2 μmol/l for DAME. Responses of a similar magnitude to exogenous acetylcholine were unaffected.3. Thus, MEAP, MEAGL and LE had similar potencies but DAME was about seven times more potent in inhibiting cholinergic neurotransmission in the rabbit isolated atria. The site of inhibition appears to be prejunctional. |
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| title_short |
EFFECTS OF THE OPIOID PEPTIDES [MET5]ENKEPHALIN-ARG6-PHE7 AND [MET5]ENKEPHALIN-ARG6-GLY7-LEU8 ON CHOLINERGIC NEUROTRANSMISSION IN THE RABBIT ISOLATED ATRIA |
| url |
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| author2 |
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| doi_str |
10.1111/j.1440-1681.1987.tb01897.x |
| up_date |
2024-07-06T05:35:23.901Z |
| _version_ |
1803806702463614976 |
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7.400159 |