DIGITALIS ‘RECEPTORS’ DURING CHRONIC DIGOXIN TREATMENT
1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The param...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Malini, Pier Luigi [verfasserIn] Strocchi, Enrico [verfasserIn] Marata, Anna Maria [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1984 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 11(1984), 3, Seite 0 |
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volume:11 ; year:1984 ; number:3 ; pages:0 |
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| DOI / URN: |
10.1111/j.1440-1681.1984.tb00266.x |
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| 520 | |a 1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment. | ||
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10.1111/j.1440-1681.1984.tb00266.x doi (DE-627)NLEJ238615189 DE-627 ger DE-627 rakwb Malini, Pier Luigi verfasserin aut DIGITALIS ‘RECEPTORS’ DURING CHRONIC DIGOXIN TREATMENT Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| digitalis Strocchi, Enrico verfasserin aut Marata, Anna Maria verfasserin aut Ambrosioni, Ettore oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 11(1984), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:11 year:1984 number:3 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1984.tb00266.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1984 3 0 |
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10.1111/j.1440-1681.1984.tb00266.x doi (DE-627)NLEJ238615189 DE-627 ger DE-627 rakwb Malini, Pier Luigi verfasserin aut DIGITALIS ‘RECEPTORS’ DURING CHRONIC DIGOXIN TREATMENT Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| digitalis Strocchi, Enrico verfasserin aut Marata, Anna Maria verfasserin aut Ambrosioni, Ettore oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 11(1984), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:11 year:1984 number:3 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1984.tb00266.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1984 3 0 |
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10.1111/j.1440-1681.1984.tb00266.x doi (DE-627)NLEJ238615189 DE-627 ger DE-627 rakwb Malini, Pier Luigi verfasserin aut DIGITALIS ‘RECEPTORS’ DURING CHRONIC DIGOXIN TREATMENT Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| digitalis Strocchi, Enrico verfasserin aut Marata, Anna Maria verfasserin aut Ambrosioni, Ettore oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 11(1984), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:11 year:1984 number:3 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1984.tb00266.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1984 3 0 |
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10.1111/j.1440-1681.1984.tb00266.x doi (DE-627)NLEJ238615189 DE-627 ger DE-627 rakwb Malini, Pier Luigi verfasserin aut DIGITALIS ‘RECEPTORS’ DURING CHRONIC DIGOXIN TREATMENT Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| digitalis Strocchi, Enrico verfasserin aut Marata, Anna Maria verfasserin aut Ambrosioni, Ettore oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 11(1984), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:11 year:1984 number:3 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1984.tb00266.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1984 3 0 |
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10.1111/j.1440-1681.1984.tb00266.x doi (DE-627)NLEJ238615189 DE-627 ger DE-627 rakwb Malini, Pier Luigi verfasserin aut DIGITALIS ‘RECEPTORS’ DURING CHRONIC DIGOXIN TREATMENT Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| digitalis Strocchi, Enrico verfasserin aut Marata, Anna Maria verfasserin aut Ambrosioni, Ettore oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 11(1984), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:11 year:1984 number:3 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1984.tb00266.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1984 3 0 |
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1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment. |
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1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment. |
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1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ238615189</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505191902.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120417s1984 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1440-1681.1984.tb00266.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ238615189</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Malini, Pier Luigi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">DIGITALIS ‘RECEPTORS’ DURING CHRONIC DIGOXIN TREATMENT</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1984</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">1. The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y.2. The results indicate that the cells adapt to chronic exposure to ‘therapeutic’ dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established.3. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2007</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2007||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">digitalis</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Strocchi, Enrico</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marata, Anna Maria</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ambrosioni, Ettore</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Clinical and experimental pharmacology and physiology</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1974</subfield><subfield code="g">11(1984), 3, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243927150</subfield><subfield code="w">(DE-600)2020033-X</subfield><subfield code="x">1440-1681</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:11</subfield><subfield code="g">year:1984</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1440-1681.1984.tb00266.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">11</subfield><subfield code="j">1984</subfield><subfield code="e">3</subfield><subfield code="h">0</subfield></datafield></record></collection>
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