Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells
Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support...
Ausführliche Beschreibung
Autor*in: |
Thorsen, S. [verfasserIn] Fogh, K. [verfasserIn] Broby-Johansen, U. [verfasserIn] |
---|
Format: |
E-Artikel |
---|
Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1990 |
---|
Schlagwörter: |
---|
Umfang: |
Online-Ressource |
---|
Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
---|---|
Übergeordnetes Werk: |
In: Allergy - Oxford : Blackwell Munksgaard, 1978, 45(1990), 6, Seite 0 |
Übergeordnetes Werk: |
volume:45 ; year:1990 ; number:6 ; pages:0 |
Links: |
---|
DOI / URN: |
10.1111/j.1398-9995.1990.tb01097.x |
---|
Katalog-ID: |
NLEJ239286693 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLEJ239286693 | ||
003 | DE-627 | ||
005 | 20210707082822.0 | ||
007 | cr uuu---uuuuu | ||
008 | 120426s1990 xx |||||o 00| ||und c | ||
024 | 7 | |a 10.1111/j.1398-9995.1990.tb01097.x |2 doi | |
035 | |a (DE-627)NLEJ239286693 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
100 | 1 | |a Thorsen, S. |e verfasserin |4 aut | |
245 | 1 | 0 | |a Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells |
264 | 1 | |a Oxford, UK |b Blackwell Publishing Ltd |c 1990 | |
300 | |a Online-Ressource | ||
336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
337 | |a nicht spezifiziert |b z |2 rdamedia | ||
338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
520 | |a Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis. | ||
533 | |d 2007 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2007|||||||||| | ||
650 | 4 | |a leukotriene B | |
700 | 1 | |a Fogh, K. |e verfasserin |4 aut | |
700 | 1 | |a Broby-Johansen, U. |e verfasserin |4 aut | |
700 | 1 | |a Sosndergaard, J. |4 oth | |
773 | 0 | 8 | |i In |t Allergy |d Oxford : Blackwell Munksgaard, 1978 |g 45(1990), 6, Seite 0 |h Online-Ressource |w (DE-627)NLEJ243926979 |w (DE-600)2003114-2 |x 1398-9995 |7 nnns |
773 | 1 | 8 | |g volume:45 |g year:1990 |g number:6 |g pages:0 |
856 | 4 | 0 | |u http://dx.doi.org/10.1111/j.1398-9995.1990.tb01097.x |q text/html |x Verlag |z Deutschlandweit zugänglich |3 Volltext |
912 | |a GBV_USEFLAG_U | ||
912 | |a ZDB-1-DJB | ||
912 | |a GBV_NL_ARTICLE | ||
951 | |a AR | ||
952 | |d 45 |j 1990 |e 6 |h 0 |
author_variant |
s t st k f kf u b j ubj |
---|---|
matchkey_str |
article:13989995:1990----::ektinbiaoidraiiicesdkneesnatrdestv |
hierarchy_sort_str |
1990 |
publishDate |
1990 |
allfields |
10.1111/j.1398-9995.1990.tb01097.x doi (DE-627)NLEJ239286693 DE-627 ger DE-627 rakwb Thorsen, S. verfasserin aut Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| leukotriene B Fogh, K. verfasserin aut Broby-Johansen, U. verfasserin aut Sosndergaard, J. oth In Allergy Oxford : Blackwell Munksgaard, 1978 45(1990), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:45 year:1990 number:6 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1990.tb01097.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 45 1990 6 0 |
spelling |
10.1111/j.1398-9995.1990.tb01097.x doi (DE-627)NLEJ239286693 DE-627 ger DE-627 rakwb Thorsen, S. verfasserin aut Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| leukotriene B Fogh, K. verfasserin aut Broby-Johansen, U. verfasserin aut Sosndergaard, J. oth In Allergy Oxford : Blackwell Munksgaard, 1978 45(1990), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:45 year:1990 number:6 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1990.tb01097.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 45 1990 6 0 |
allfields_unstemmed |
10.1111/j.1398-9995.1990.tb01097.x doi (DE-627)NLEJ239286693 DE-627 ger DE-627 rakwb Thorsen, S. verfasserin aut Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| leukotriene B Fogh, K. verfasserin aut Broby-Johansen, U. verfasserin aut Sosndergaard, J. oth In Allergy Oxford : Blackwell Munksgaard, 1978 45(1990), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:45 year:1990 number:6 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1990.tb01097.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 45 1990 6 0 |
allfieldsGer |
10.1111/j.1398-9995.1990.tb01097.x doi (DE-627)NLEJ239286693 DE-627 ger DE-627 rakwb Thorsen, S. verfasserin aut Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| leukotriene B Fogh, K. verfasserin aut Broby-Johansen, U. verfasserin aut Sosndergaard, J. oth In Allergy Oxford : Blackwell Munksgaard, 1978 45(1990), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:45 year:1990 number:6 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1990.tb01097.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 45 1990 6 0 |
allfieldsSound |
10.1111/j.1398-9995.1990.tb01097.x doi (DE-627)NLEJ239286693 DE-627 ger DE-627 rakwb Thorsen, S. verfasserin aut Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| leukotriene B Fogh, K. verfasserin aut Broby-Johansen, U. verfasserin aut Sosndergaard, J. oth In Allergy Oxford : Blackwell Munksgaard, 1978 45(1990), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:45 year:1990 number:6 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1990.tb01097.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 45 1990 6 0 |
source |
In Allergy 45(1990), 6, Seite 0 volume:45 year:1990 number:6 pages:0 |
sourceStr |
In Allergy 45(1990), 6, Seite 0 volume:45 year:1990 number:6 pages:0 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
leukotriene B |
isfreeaccess_bool |
false |
container_title |
Allergy |
authorswithroles_txt_mv |
Thorsen, S. @@aut@@ Fogh, K. @@aut@@ Broby-Johansen, U. @@aut@@ Sosndergaard, J. @@oth@@ |
publishDateDaySort_date |
1990-01-01T00:00:00Z |
hierarchy_top_id |
NLEJ243926979 |
id |
NLEJ239286693 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ239286693</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707082822.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120426s1990 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1398-9995.1990.tb01097.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ239286693</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Thorsen, S.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1990</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2007</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2007||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">leukotriene B</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fogh, K.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Broby-Johansen, U.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sosndergaard, J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Allergy</subfield><subfield code="d">Oxford : Blackwell Munksgaard, 1978</subfield><subfield code="g">45(1990), 6, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926979</subfield><subfield code="w">(DE-600)2003114-2</subfield><subfield code="x">1398-9995</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:45</subfield><subfield code="g">year:1990</subfield><subfield code="g">number:6</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1398-9995.1990.tb01097.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">45</subfield><subfield code="j">1990</subfield><subfield code="e">6</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
series2 |
Blackwell Publishing Journal Backfiles 1879-2005 |
author |
Thorsen, S. |
spellingShingle |
Thorsen, S. misc leukotriene B Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells |
authorStr |
Thorsen, S. |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ243926979 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut aut |
collection |
NL |
publishPlace |
Oxford, UK |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
1398-9995 |
topic_title |
Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells leukotriene B |
publisher |
Blackwell Publishing Ltd |
publisherStr |
Blackwell Publishing Ltd |
topic |
misc leukotriene B |
topic_unstemmed |
misc leukotriene B |
topic_browse |
misc leukotriene B |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
zu |
author2_variant |
j s js |
hierarchy_parent_title |
Allergy |
hierarchy_parent_id |
NLEJ243926979 |
hierarchy_top_title |
Allergy |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)NLEJ243926979 (DE-600)2003114-2 |
title |
Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells |
ctrlnum |
(DE-627)NLEJ239286693 |
title_full |
Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells |
author_sort |
Thorsen, S. |
journal |
Allergy |
journalStr |
Allergy |
isOA_bool |
false |
recordtype |
marc |
publishDateSort |
1990 |
contenttype_str_mv |
zzz |
container_start_page |
0 |
author_browse |
Thorsen, S. Fogh, K. Broby-Johansen, U. |
container_volume |
45 |
physical |
Online-Ressource |
format_se |
Elektronische Aufsätze |
author-letter |
Thorsen, S. |
doi_str_mv |
10.1111/j.1398-9995.1990.tb01097.x |
author2-role |
verfasserin |
title_sort |
leukotriene b4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood t-cells |
title_auth |
Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells |
abstract |
Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis. |
abstractGer |
Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis. |
abstract_unstemmed |
Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis. |
collection_details |
GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE |
container_issue |
6 |
title_short |
Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells |
url |
http://dx.doi.org/10.1111/j.1398-9995.1990.tb01097.x |
remote_bool |
true |
author2 |
Fogh, K. Broby-Johansen, U. Sosndergaard, J. |
author2Str |
Fogh, K. Broby-Johansen, U. Sosndergaard, J. |
ppnlink |
NLEJ243926979 |
mediatype_str_mv |
z |
isOA_txt |
false |
hochschulschrift_bool |
false |
author2_role |
oth |
doi_str |
10.1111/j.1398-9995.1990.tb01097.x |
up_date |
2024-07-06T07:07:07.278Z |
_version_ |
1803812473174753280 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ239286693</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707082822.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120426s1990 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1398-9995.1990.tb01097.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ239286693</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Thorsen, S.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Leukotriene B4 in atopic dermatitis: increased skin levels and altered sensitivity of peripheral blood T-cells</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1990</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Employing a radioimmunoassay, de-proteinated suction blister fluid from 12 patients with active atopic dermatitis appeared to contain higher levels of the pro-inflammatory and immunomodulatory mediator leukotriene B4 (LTB4) than suction blister fluid from 12 non-atopic individuals. Indirect support for the identity of the mediator was obtained by HPLC of pooled samples. Nylon wool enriched T cells from six patients with atopic dermatitis and six non-atopic people preincubated with LTB4 (10−10 M−10−8 M) expressed no statistically significant suppression in co-culture with mitogen stimulated autologous mononuclear cells, and there was no difference between atopic and non-atopic T cells in this respect. In contrast, LTB4 induced a dose-dependent reduction in the percentage of phenotypic Leu 2a (suppressor) cells leading to an increased helper/suppressor ratio in five atopic patients that was not observed in five non-atopics. Elevated skin levels of LTB4 may initiate or amplify dermal inflammation, and abnormal T cell response to the mediator may account for the increased helper/suppressor ratio characteristic of patients with atopic dermatitis.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2007</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2007||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">leukotriene B</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fogh, K.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Broby-Johansen, U.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sosndergaard, J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Allergy</subfield><subfield code="d">Oxford : Blackwell Munksgaard, 1978</subfield><subfield code="g">45(1990), 6, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926979</subfield><subfield code="w">(DE-600)2003114-2</subfield><subfield code="x">1398-9995</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:45</subfield><subfield code="g">year:1990</subfield><subfield code="g">number:6</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1398-9995.1990.tb01097.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">45</subfield><subfield code="j">1990</subfield><subfield code="e">6</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
score |
7.400754 |