Clinical and Immunological Aspects of a Case of Monoclonal Hyper-IgE
A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipit...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Malling, H.-J. [verfasserIn] Djurup, R. [verfasserIn] Stahl Skov, P. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1985 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Allergy - Oxford : Blackwell Munksgaard, 1978, 40(1985), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:40 ; year:1985 ; number:4 ; pages:0 |
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| DOI / URN: |
10.1111/j.1398-9995.1985.tb00229.x |
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| 520 | |a A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipitation, gel filtration, chromatofocusing, and subtraction affinity chromatography the IgE protein was isolated in an immunochemically pure and homogeneous form. Immunofluorescence of bone marrow cells showed about 1 % IgE plasma cells. The amount of basophil bound IgE was 42 ng/106 cells, and histamine release from basophils challenged with anti-IgE was not different from that in atopic control persons, indicating a within-allergic-patients normal amount of IgE receptors. The protein-A reactivity was 0.4% equivalent to well-known IgE myeloma proteins. No antigen specificity of the IgE protein was found. Only a few cases of asymptomatic hyper-IgE are known, and it cannot be ruled out that this represents a premyeloma condition, since a similar case terminated in a malignant lymphoma. | ||
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10.1111/j.1398-9995.1985.tb00229.x doi (DE-627)NLEJ239293185 DE-627 ger DE-627 rakwb Malling, H.-J. verfasserin aut Clinical and Immunological Aspects of a Case of Monoclonal Hyper-IgE Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipitation, gel filtration, chromatofocusing, and subtraction affinity chromatography the IgE protein was isolated in an immunochemically pure and homogeneous form. Immunofluorescence of bone marrow cells showed about 1 % IgE plasma cells. The amount of basophil bound IgE was 42 ng/106 cells, and histamine release from basophils challenged with anti-IgE was not different from that in atopic control persons, indicating a within-allergic-patients normal amount of IgE receptors. The protein-A reactivity was 0.4% equivalent to well-known IgE myeloma proteins. No antigen specificity of the IgE protein was found. Only a few cases of asymptomatic hyper-IgE are known, and it cannot be ruled out that this represents a premyeloma condition, since a similar case terminated in a malignant lymphoma. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| immunoglobulin E Djurup, R. verfasserin aut Stahl Skov, P. verfasserin aut Permin, H. oth Magnusson, C. G. M. oth Søsborg, M. oth Søsndergaard, I. oth Weeke, B. oth In Allergy Oxford : Blackwell Munksgaard, 1978 40(1985), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:40 year:1985 number:4 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1985.tb00229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 40 1985 4 0 |
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10.1111/j.1398-9995.1985.tb00229.x doi (DE-627)NLEJ239293185 DE-627 ger DE-627 rakwb Malling, H.-J. verfasserin aut Clinical and Immunological Aspects of a Case of Monoclonal Hyper-IgE Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipitation, gel filtration, chromatofocusing, and subtraction affinity chromatography the IgE protein was isolated in an immunochemically pure and homogeneous form. Immunofluorescence of bone marrow cells showed about 1 % IgE plasma cells. The amount of basophil bound IgE was 42 ng/106 cells, and histamine release from basophils challenged with anti-IgE was not different from that in atopic control persons, indicating a within-allergic-patients normal amount of IgE receptors. The protein-A reactivity was 0.4% equivalent to well-known IgE myeloma proteins. No antigen specificity of the IgE protein was found. Only a few cases of asymptomatic hyper-IgE are known, and it cannot be ruled out that this represents a premyeloma condition, since a similar case terminated in a malignant lymphoma. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| immunoglobulin E Djurup, R. verfasserin aut Stahl Skov, P. verfasserin aut Permin, H. oth Magnusson, C. G. M. oth Søsborg, M. oth Søsndergaard, I. oth Weeke, B. oth In Allergy Oxford : Blackwell Munksgaard, 1978 40(1985), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:40 year:1985 number:4 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1985.tb00229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 40 1985 4 0 |
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10.1111/j.1398-9995.1985.tb00229.x doi (DE-627)NLEJ239293185 DE-627 ger DE-627 rakwb Malling, H.-J. verfasserin aut Clinical and Immunological Aspects of a Case of Monoclonal Hyper-IgE Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipitation, gel filtration, chromatofocusing, and subtraction affinity chromatography the IgE protein was isolated in an immunochemically pure and homogeneous form. Immunofluorescence of bone marrow cells showed about 1 % IgE plasma cells. The amount of basophil bound IgE was 42 ng/106 cells, and histamine release from basophils challenged with anti-IgE was not different from that in atopic control persons, indicating a within-allergic-patients normal amount of IgE receptors. The protein-A reactivity was 0.4% equivalent to well-known IgE myeloma proteins. No antigen specificity of the IgE protein was found. Only a few cases of asymptomatic hyper-IgE are known, and it cannot be ruled out that this represents a premyeloma condition, since a similar case terminated in a malignant lymphoma. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| immunoglobulin E Djurup, R. verfasserin aut Stahl Skov, P. verfasserin aut Permin, H. oth Magnusson, C. G. M. oth Søsborg, M. oth Søsndergaard, I. oth Weeke, B. oth In Allergy Oxford : Blackwell Munksgaard, 1978 40(1985), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:40 year:1985 number:4 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1985.tb00229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 40 1985 4 0 |
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10.1111/j.1398-9995.1985.tb00229.x doi (DE-627)NLEJ239293185 DE-627 ger DE-627 rakwb Malling, H.-J. verfasserin aut Clinical and Immunological Aspects of a Case of Monoclonal Hyper-IgE Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipitation, gel filtration, chromatofocusing, and subtraction affinity chromatography the IgE protein was isolated in an immunochemically pure and homogeneous form. Immunofluorescence of bone marrow cells showed about 1 % IgE plasma cells. The amount of basophil bound IgE was 42 ng/106 cells, and histamine release from basophils challenged with anti-IgE was not different from that in atopic control persons, indicating a within-allergic-patients normal amount of IgE receptors. The protein-A reactivity was 0.4% equivalent to well-known IgE myeloma proteins. No antigen specificity of the IgE protein was found. Only a few cases of asymptomatic hyper-IgE are known, and it cannot be ruled out that this represents a premyeloma condition, since a similar case terminated in a malignant lymphoma. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| immunoglobulin E Djurup, R. verfasserin aut Stahl Skov, P. verfasserin aut Permin, H. oth Magnusson, C. G. M. oth Søsborg, M. oth Søsndergaard, I. oth Weeke, B. oth In Allergy Oxford : Blackwell Munksgaard, 1978 40(1985), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:40 year:1985 number:4 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1985.tb00229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 40 1985 4 0 |
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10.1111/j.1398-9995.1985.tb00229.x doi (DE-627)NLEJ239293185 DE-627 ger DE-627 rakwb Malling, H.-J. verfasserin aut Clinical and Immunological Aspects of a Case of Monoclonal Hyper-IgE Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipitation, gel filtration, chromatofocusing, and subtraction affinity chromatography the IgE protein was isolated in an immunochemically pure and homogeneous form. Immunofluorescence of bone marrow cells showed about 1 % IgE plasma cells. The amount of basophil bound IgE was 42 ng/106 cells, and histamine release from basophils challenged with anti-IgE was not different from that in atopic control persons, indicating a within-allergic-patients normal amount of IgE receptors. The protein-A reactivity was 0.4% equivalent to well-known IgE myeloma proteins. No antigen specificity of the IgE protein was found. Only a few cases of asymptomatic hyper-IgE are known, and it cannot be ruled out that this represents a premyeloma condition, since a similar case terminated in a malignant lymphoma. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| immunoglobulin E Djurup, R. verfasserin aut Stahl Skov, P. verfasserin aut Permin, H. oth Magnusson, C. G. M. oth Søsborg, M. oth Søsndergaard, I. oth Weeke, B. oth In Allergy Oxford : Blackwell Munksgaard, 1978 40(1985), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:40 year:1985 number:4 pages:0 http://dx.doi.org/10.1111/j.1398-9995.1985.tb00229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 40 1985 4 0 |
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Clinical and Immunological Aspects of a Case of Monoclonal Hyper-IgE |
| abstract |
A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipitation, gel filtration, chromatofocusing, and subtraction affinity chromatography the IgE protein was isolated in an immunochemically pure and homogeneous form. Immunofluorescence of bone marrow cells showed about 1 % IgE plasma cells. The amount of basophil bound IgE was 42 ng/106 cells, and histamine release from basophils challenged with anti-IgE was not different from that in atopic control persons, indicating a within-allergic-patients normal amount of IgE receptors. The protein-A reactivity was 0.4% equivalent to well-known IgE myeloma proteins. No antigen specificity of the IgE protein was found. Only a few cases of asymptomatic hyper-IgE are known, and it cannot be ruled out that this represents a premyeloma condition, since a similar case terminated in a malignant lymphoma. |
| abstractGer |
A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipitation, gel filtration, chromatofocusing, and subtraction affinity chromatography the IgE protein was isolated in an immunochemically pure and homogeneous form. Immunofluorescence of bone marrow cells showed about 1 % IgE plasma cells. The amount of basophil bound IgE was 42 ng/106 cells, and histamine release from basophils challenged with anti-IgE was not different from that in atopic control persons, indicating a within-allergic-patients normal amount of IgE receptors. The protein-A reactivity was 0.4% equivalent to well-known IgE myeloma proteins. No antigen specificity of the IgE protein was found. Only a few cases of asymptomatic hyper-IgE are known, and it cannot be ruled out that this represents a premyeloma condition, since a similar case terminated in a malignant lymphoma. |
| abstract_unstemmed |
A case of monoclonal IgE type lambda with IgE levels about 1 mg/ml has been followed for 6 years. Except for a slight asthma no signs of malignancies, parasitic infestations or other known diseases compatible with hyper-IgE have been found. By the combination of fractional ammonium sulphate precipitation, gel filtration, chromatofocusing, and subtraction affinity chromatography the IgE protein was isolated in an immunochemically pure and homogeneous form. Immunofluorescence of bone marrow cells showed about 1 % IgE plasma cells. The amount of basophil bound IgE was 42 ng/106 cells, and histamine release from basophils challenged with anti-IgE was not different from that in atopic control persons, indicating a within-allergic-patients normal amount of IgE receptors. The protein-A reactivity was 0.4% equivalent to well-known IgE myeloma proteins. No antigen specificity of the IgE protein was found. Only a few cases of asymptomatic hyper-IgE are known, and it cannot be ruled out that this represents a premyeloma condition, since a similar case terminated in a malignant lymphoma. |
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Clinical and Immunological Aspects of a Case of Monoclonal Hyper-IgE |
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Djurup, R. Stahl Skov, P. Permin, H. Magnusson, C. G. M. Søsborg, M. Søsndergaard, I. Weeke, B. |
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Djurup, R. Stahl Skov, P. Permin, H. Magnusson, C. G. M. Søsborg, M. Søsndergaard, I. Weeke, B. |
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10.1111/j.1398-9995.1985.tb00229.x |
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