A new approach to the histologic study of ovarian tumors by analytical morphometry
In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuc...
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| Autor*in: |
Resta, L. [verfasserIn] Ricco, R. [verfasserIn] Colucci, G.A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
238 Main Street, Cambridge, Massachusetts 02142, USA: Blackwell Scientific Publications ; 1992 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2002 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: International journal of gynecological cancer - Oxford [u.a.] : Wiley-Blackwell, 1991, 2(1992), 6, Seite 0 |
| Übergeordnetes Werk: |
volume:2 ; year:1992 ; number:6 ; pages:0 |
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| DOI / URN: |
10.1046/j.1525-1438.1992.02060307.x |
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| 520 | |a In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuclear shape in epithelial ovarian tumors. Sixty nuclei of benign ovarian serous neoplasms, 60 nuclei of serous borderline tumors and 60 nuclei of serous carcinomas (18 cases in all) were examined using the software system SAM (Shape Analytical Morphometry). The morphometric procedure consisted of three different phases: (i) extraction of nuclear fundamental curve: this is a function curve giving the smoothing of the original contour by two parametric equations (separately for x and y values as dependent variables); (ii) evaluation of nuclear contour irregularities by Fourier analysis; (iii) evaluation of nuclear shape asymmetry by SAE (Shape Asymmetry Evaluator): this is the ratio between the length of a segment of a parabola interpolating the original curve points and a straight line joining its extremities for a 180° barycentric rotation according 10° steps. All the obtained independent parameters were submitted to statistical analysis. Nuclei of borderline tumors showed dimensional parameters which were intermediate between those of benign and malignant tumors. Both the asymmetry and the irregularities of nuclear contour were greatest in carcinomas. | ||
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10.1046/j.1525-1438.1992.02060307.x doi (DE-627)NLEJ239411277 DE-627 ger DE-627 rakwb Resta, L. verfasserin aut A new approach to the histologic study of ovarian tumors by analytical morphometry 238 Main Street, Cambridge, Massachusetts 02142, USA Blackwell Scientific Publications 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuclear shape in epithelial ovarian tumors. Sixty nuclei of benign ovarian serous neoplasms, 60 nuclei of serous borderline tumors and 60 nuclei of serous carcinomas (18 cases in all) were examined using the software system SAM (Shape Analytical Morphometry). The morphometric procedure consisted of three different phases: (i) extraction of nuclear fundamental curve: this is a function curve giving the smoothing of the original contour by two parametric equations (separately for x and y values as dependent variables); (ii) evaluation of nuclear contour irregularities by Fourier analysis; (iii) evaluation of nuclear shape asymmetry by SAE (Shape Asymmetry Evaluator): this is the ratio between the length of a segment of a parabola interpolating the original curve points and a straight line joining its extremities for a 180° barycentric rotation according 10° steps. All the obtained independent parameters were submitted to statistical analysis. Nuclei of borderline tumors showed dimensional parameters which were intermediate between those of benign and malignant tumors. Both the asymmetry and the irregularities of nuclear contour were greatest in carcinomas. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| analytical morphometry Ricco, R. verfasserin aut Colucci, G.A. verfasserin aut Troia, M. oth Russo, S. oth Vacca, E. oth Delfino, V. Pesce oth In International journal of gynecological cancer Oxford [u.a.] : Wiley-Blackwell, 1991 2(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926197 (DE-600)2009072-9 1525-1438 nnns volume:2 year:1992 number:6 pages:0 http://dx.doi.org/10.1046/j.1525-1438.1992.02060307.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1992 6 0 |
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10.1046/j.1525-1438.1992.02060307.x doi (DE-627)NLEJ239411277 DE-627 ger DE-627 rakwb Resta, L. verfasserin aut A new approach to the histologic study of ovarian tumors by analytical morphometry 238 Main Street, Cambridge, Massachusetts 02142, USA Blackwell Scientific Publications 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuclear shape in epithelial ovarian tumors. Sixty nuclei of benign ovarian serous neoplasms, 60 nuclei of serous borderline tumors and 60 nuclei of serous carcinomas (18 cases in all) were examined using the software system SAM (Shape Analytical Morphometry). The morphometric procedure consisted of three different phases: (i) extraction of nuclear fundamental curve: this is a function curve giving the smoothing of the original contour by two parametric equations (separately for x and y values as dependent variables); (ii) evaluation of nuclear contour irregularities by Fourier analysis; (iii) evaluation of nuclear shape asymmetry by SAE (Shape Asymmetry Evaluator): this is the ratio between the length of a segment of a parabola interpolating the original curve points and a straight line joining its extremities for a 180° barycentric rotation according 10° steps. All the obtained independent parameters were submitted to statistical analysis. Nuclei of borderline tumors showed dimensional parameters which were intermediate between those of benign and malignant tumors. Both the asymmetry and the irregularities of nuclear contour were greatest in carcinomas. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| analytical morphometry Ricco, R. verfasserin aut Colucci, G.A. verfasserin aut Troia, M. oth Russo, S. oth Vacca, E. oth Delfino, V. Pesce oth In International journal of gynecological cancer Oxford [u.a.] : Wiley-Blackwell, 1991 2(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926197 (DE-600)2009072-9 1525-1438 nnns volume:2 year:1992 number:6 pages:0 http://dx.doi.org/10.1046/j.1525-1438.1992.02060307.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1992 6 0 |
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10.1046/j.1525-1438.1992.02060307.x doi (DE-627)NLEJ239411277 DE-627 ger DE-627 rakwb Resta, L. verfasserin aut A new approach to the histologic study of ovarian tumors by analytical morphometry 238 Main Street, Cambridge, Massachusetts 02142, USA Blackwell Scientific Publications 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuclear shape in epithelial ovarian tumors. Sixty nuclei of benign ovarian serous neoplasms, 60 nuclei of serous borderline tumors and 60 nuclei of serous carcinomas (18 cases in all) were examined using the software system SAM (Shape Analytical Morphometry). The morphometric procedure consisted of three different phases: (i) extraction of nuclear fundamental curve: this is a function curve giving the smoothing of the original contour by two parametric equations (separately for x and y values as dependent variables); (ii) evaluation of nuclear contour irregularities by Fourier analysis; (iii) evaluation of nuclear shape asymmetry by SAE (Shape Asymmetry Evaluator): this is the ratio between the length of a segment of a parabola interpolating the original curve points and a straight line joining its extremities for a 180° barycentric rotation according 10° steps. All the obtained independent parameters were submitted to statistical analysis. Nuclei of borderline tumors showed dimensional parameters which were intermediate between those of benign and malignant tumors. Both the asymmetry and the irregularities of nuclear contour were greatest in carcinomas. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| analytical morphometry Ricco, R. verfasserin aut Colucci, G.A. verfasserin aut Troia, M. oth Russo, S. oth Vacca, E. oth Delfino, V. Pesce oth In International journal of gynecological cancer Oxford [u.a.] : Wiley-Blackwell, 1991 2(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926197 (DE-600)2009072-9 1525-1438 nnns volume:2 year:1992 number:6 pages:0 http://dx.doi.org/10.1046/j.1525-1438.1992.02060307.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1992 6 0 |
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10.1046/j.1525-1438.1992.02060307.x doi (DE-627)NLEJ239411277 DE-627 ger DE-627 rakwb Resta, L. verfasserin aut A new approach to the histologic study of ovarian tumors by analytical morphometry 238 Main Street, Cambridge, Massachusetts 02142, USA Blackwell Scientific Publications 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuclear shape in epithelial ovarian tumors. Sixty nuclei of benign ovarian serous neoplasms, 60 nuclei of serous borderline tumors and 60 nuclei of serous carcinomas (18 cases in all) were examined using the software system SAM (Shape Analytical Morphometry). The morphometric procedure consisted of three different phases: (i) extraction of nuclear fundamental curve: this is a function curve giving the smoothing of the original contour by two parametric equations (separately for x and y values as dependent variables); (ii) evaluation of nuclear contour irregularities by Fourier analysis; (iii) evaluation of nuclear shape asymmetry by SAE (Shape Asymmetry Evaluator): this is the ratio between the length of a segment of a parabola interpolating the original curve points and a straight line joining its extremities for a 180° barycentric rotation according 10° steps. All the obtained independent parameters were submitted to statistical analysis. Nuclei of borderline tumors showed dimensional parameters which were intermediate between those of benign and malignant tumors. Both the asymmetry and the irregularities of nuclear contour were greatest in carcinomas. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| analytical morphometry Ricco, R. verfasserin aut Colucci, G.A. verfasserin aut Troia, M. oth Russo, S. oth Vacca, E. oth Delfino, V. Pesce oth In International journal of gynecological cancer Oxford [u.a.] : Wiley-Blackwell, 1991 2(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926197 (DE-600)2009072-9 1525-1438 nnns volume:2 year:1992 number:6 pages:0 http://dx.doi.org/10.1046/j.1525-1438.1992.02060307.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1992 6 0 |
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10.1046/j.1525-1438.1992.02060307.x doi (DE-627)NLEJ239411277 DE-627 ger DE-627 rakwb Resta, L. verfasserin aut A new approach to the histologic study of ovarian tumors by analytical morphometry 238 Main Street, Cambridge, Massachusetts 02142, USA Blackwell Scientific Publications 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuclear shape in epithelial ovarian tumors. Sixty nuclei of benign ovarian serous neoplasms, 60 nuclei of serous borderline tumors and 60 nuclei of serous carcinomas (18 cases in all) were examined using the software system SAM (Shape Analytical Morphometry). The morphometric procedure consisted of three different phases: (i) extraction of nuclear fundamental curve: this is a function curve giving the smoothing of the original contour by two parametric equations (separately for x and y values as dependent variables); (ii) evaluation of nuclear contour irregularities by Fourier analysis; (iii) evaluation of nuclear shape asymmetry by SAE (Shape Asymmetry Evaluator): this is the ratio between the length of a segment of a parabola interpolating the original curve points and a straight line joining its extremities for a 180° barycentric rotation according 10° steps. All the obtained independent parameters were submitted to statistical analysis. Nuclei of borderline tumors showed dimensional parameters which were intermediate between those of benign and malignant tumors. Both the asymmetry and the irregularities of nuclear contour were greatest in carcinomas. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| analytical morphometry Ricco, R. verfasserin aut Colucci, G.A. verfasserin aut Troia, M. oth Russo, S. oth Vacca, E. oth Delfino, V. Pesce oth In International journal of gynecological cancer Oxford [u.a.] : Wiley-Blackwell, 1991 2(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926197 (DE-600)2009072-9 1525-1438 nnns volume:2 year:1992 number:6 pages:0 http://dx.doi.org/10.1046/j.1525-1438.1992.02060307.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1992 6 0 |
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A new approach to the histologic study of ovarian tumors by analytical morphometry |
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In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuclear shape in epithelial ovarian tumors. Sixty nuclei of benign ovarian serous neoplasms, 60 nuclei of serous borderline tumors and 60 nuclei of serous carcinomas (18 cases in all) were examined using the software system SAM (Shape Analytical Morphometry). The morphometric procedure consisted of three different phases: (i) extraction of nuclear fundamental curve: this is a function curve giving the smoothing of the original contour by two parametric equations (separately for x and y values as dependent variables); (ii) evaluation of nuclear contour irregularities by Fourier analysis; (iii) evaluation of nuclear shape asymmetry by SAE (Shape Asymmetry Evaluator): this is the ratio between the length of a segment of a parabola interpolating the original curve points and a straight line joining its extremities for a 180° barycentric rotation according 10° steps. All the obtained independent parameters were submitted to statistical analysis. Nuclei of borderline tumors showed dimensional parameters which were intermediate between those of benign and malignant tumors. Both the asymmetry and the irregularities of nuclear contour were greatest in carcinomas. |
| abstractGer |
In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuclear shape in epithelial ovarian tumors. Sixty nuclei of benign ovarian serous neoplasms, 60 nuclei of serous borderline tumors and 60 nuclei of serous carcinomas (18 cases in all) were examined using the software system SAM (Shape Analytical Morphometry). The morphometric procedure consisted of three different phases: (i) extraction of nuclear fundamental curve: this is a function curve giving the smoothing of the original contour by two parametric equations (separately for x and y values as dependent variables); (ii) evaluation of nuclear contour irregularities by Fourier analysis; (iii) evaluation of nuclear shape asymmetry by SAE (Shape Asymmetry Evaluator): this is the ratio between the length of a segment of a parabola interpolating the original curve points and a straight line joining its extremities for a 180° barycentric rotation according 10° steps. All the obtained independent parameters were submitted to statistical analysis. Nuclei of borderline tumors showed dimensional parameters which were intermediate between those of benign and malignant tumors. Both the asymmetry and the irregularities of nuclear contour were greatest in carcinomas. |
| abstract_unstemmed |
In recent years, borderline epithelial tumors of the ovary have been investigated by morphometric techniques to allow for a differential diagnosis from benign and malignant neoplasms. In order to enhance this discriminant power, we have applied a new analytical procedure to the evaluation of the nuclear shape in epithelial ovarian tumors. Sixty nuclei of benign ovarian serous neoplasms, 60 nuclei of serous borderline tumors and 60 nuclei of serous carcinomas (18 cases in all) were examined using the software system SAM (Shape Analytical Morphometry). The morphometric procedure consisted of three different phases: (i) extraction of nuclear fundamental curve: this is a function curve giving the smoothing of the original contour by two parametric equations (separately for x and y values as dependent variables); (ii) evaluation of nuclear contour irregularities by Fourier analysis; (iii) evaluation of nuclear shape asymmetry by SAE (Shape Asymmetry Evaluator): this is the ratio between the length of a segment of a parabola interpolating the original curve points and a straight line joining its extremities for a 180° barycentric rotation according 10° steps. All the obtained independent parameters were submitted to statistical analysis. Nuclei of borderline tumors showed dimensional parameters which were intermediate between those of benign and malignant tumors. Both the asymmetry and the irregularities of nuclear contour were greatest in carcinomas. |
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A new approach to the histologic study of ovarian tumors by analytical morphometry |
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Ricco, R. Colucci, G.A. Troia, M. Russo, S. Vacca, E. Delfino, V. Pesce |
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Ricco, R. Colucci, G.A. Troia, M. Russo, S. Vacca, E. Delfino, V. Pesce |
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