Classification of normal colorectal mucosa and adenocarcinoma by morphometry
Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
HAMILTON, P.W. [verfasserIn] ALLEN, D.C. [verfasserIn] WATT, P.C.H. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1987 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Histopathology - Oxford [u.a.] : Wiley-Blackwell, 1977, 11(1987), 9, Seite 0 |
| Übergeordnetes Werk: |
volume:11 ; year:1987 ; number:9 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1365-2559.1987.tb01897.x |
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NLEJ239532651 |
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| 520 | |a Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within the dataset. These were, in decreasing order of importance: (1) nuclear size, nuclear cytoplasmic ratio and nuclear position within the cell; (2) the variability of nuclear size; (3) nuclear elongation and polarity; (4) nuclear shape and its variation. Discriminant analysis was conducted between histologi-cally normal mucosa (n=10) and adenocarcinoma in ulcerative colitis (n=20). Using stepwise variable selection, the mean nuclear cytoplasmic ratio (normal, mean 20.4 (s.d. ± 2.0); tumour, mean 39.7 (s.d. ± 7.0)) and the coefficient of variation of nucleus to cell apex distance (normal, mean 19.2 (s.d ± 7.5); tumour, mean 47.8 (s.d. ± 9.1)) were chosen as discriminating features. They were used to derive a discriminant function which gave perfect discriminating between the two groups. Scatter plots of these two variables confirmed complete separation of normal mucosa from adenocarcinoma and provided a simple method of applying the discriminant function. Discriminatory performance did not deteriorate when the function was applied to further normals (n=10) and adenocarcinoma (n=10). This study highlights the descriptive differences between normal and malignant colorectal epithelium and shows that case allocation may be made to these two lesion categories using a morphometrically-derived classification rule. | ||
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10.1111/j.1365-2559.1987.tb01897.x doi (DE-627)NLEJ239532651 DE-627 ger DE-627 rakwb HAMILTON, P.W. verfasserin aut Classification of normal colorectal mucosa and adenocarcinoma by morphometry Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within the dataset. These were, in decreasing order of importance: (1) nuclear size, nuclear cytoplasmic ratio and nuclear position within the cell; (2) the variability of nuclear size; (3) nuclear elongation and polarity; (4) nuclear shape and its variation. Discriminant analysis was conducted between histologi-cally normal mucosa (n=10) and adenocarcinoma in ulcerative colitis (n=20). Using stepwise variable selection, the mean nuclear cytoplasmic ratio (normal, mean 20.4 (s.d. ± 2.0); tumour, mean 39.7 (s.d. ± 7.0)) and the coefficient of variation of nucleus to cell apex distance (normal, mean 19.2 (s.d ± 7.5); tumour, mean 47.8 (s.d. ± 9.1)) were chosen as discriminating features. They were used to derive a discriminant function which gave perfect discriminating between the two groups. Scatter plots of these two variables confirmed complete separation of normal mucosa from adenocarcinoma and provided a simple method of applying the discriminant function. Discriminatory performance did not deteriorate when the function was applied to further normals (n=10) and adenocarcinoma (n=10). This study highlights the descriptive differences between normal and malignant colorectal epithelium and shows that case allocation may be made to these two lesion categories using a morphometrically-derived classification rule. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| morphometry ALLEN, D.C. verfasserin aut WATT, P.C.H. verfasserin aut PATTERSON, C.C. oth BIGGART, J.D. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 11(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:11 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1365-2559.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1987 9 0 |
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10.1111/j.1365-2559.1987.tb01897.x doi (DE-627)NLEJ239532651 DE-627 ger DE-627 rakwb HAMILTON, P.W. verfasserin aut Classification of normal colorectal mucosa and adenocarcinoma by morphometry Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within the dataset. These were, in decreasing order of importance: (1) nuclear size, nuclear cytoplasmic ratio and nuclear position within the cell; (2) the variability of nuclear size; (3) nuclear elongation and polarity; (4) nuclear shape and its variation. Discriminant analysis was conducted between histologi-cally normal mucosa (n=10) and adenocarcinoma in ulcerative colitis (n=20). Using stepwise variable selection, the mean nuclear cytoplasmic ratio (normal, mean 20.4 (s.d. ± 2.0); tumour, mean 39.7 (s.d. ± 7.0)) and the coefficient of variation of nucleus to cell apex distance (normal, mean 19.2 (s.d ± 7.5); tumour, mean 47.8 (s.d. ± 9.1)) were chosen as discriminating features. They were used to derive a discriminant function which gave perfect discriminating between the two groups. Scatter plots of these two variables confirmed complete separation of normal mucosa from adenocarcinoma and provided a simple method of applying the discriminant function. Discriminatory performance did not deteriorate when the function was applied to further normals (n=10) and adenocarcinoma (n=10). This study highlights the descriptive differences between normal and malignant colorectal epithelium and shows that case allocation may be made to these two lesion categories using a morphometrically-derived classification rule. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| morphometry ALLEN, D.C. verfasserin aut WATT, P.C.H. verfasserin aut PATTERSON, C.C. oth BIGGART, J.D. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 11(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:11 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1365-2559.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1987 9 0 |
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10.1111/j.1365-2559.1987.tb01897.x doi (DE-627)NLEJ239532651 DE-627 ger DE-627 rakwb HAMILTON, P.W. verfasserin aut Classification of normal colorectal mucosa and adenocarcinoma by morphometry Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within the dataset. These were, in decreasing order of importance: (1) nuclear size, nuclear cytoplasmic ratio and nuclear position within the cell; (2) the variability of nuclear size; (3) nuclear elongation and polarity; (4) nuclear shape and its variation. Discriminant analysis was conducted between histologi-cally normal mucosa (n=10) and adenocarcinoma in ulcerative colitis (n=20). Using stepwise variable selection, the mean nuclear cytoplasmic ratio (normal, mean 20.4 (s.d. ± 2.0); tumour, mean 39.7 (s.d. ± 7.0)) and the coefficient of variation of nucleus to cell apex distance (normal, mean 19.2 (s.d ± 7.5); tumour, mean 47.8 (s.d. ± 9.1)) were chosen as discriminating features. They were used to derive a discriminant function which gave perfect discriminating between the two groups. Scatter plots of these two variables confirmed complete separation of normal mucosa from adenocarcinoma and provided a simple method of applying the discriminant function. Discriminatory performance did not deteriorate when the function was applied to further normals (n=10) and adenocarcinoma (n=10). This study highlights the descriptive differences between normal and malignant colorectal epithelium and shows that case allocation may be made to these two lesion categories using a morphometrically-derived classification rule. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| morphometry ALLEN, D.C. verfasserin aut WATT, P.C.H. verfasserin aut PATTERSON, C.C. oth BIGGART, J.D. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 11(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:11 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1365-2559.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1987 9 0 |
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10.1111/j.1365-2559.1987.tb01897.x doi (DE-627)NLEJ239532651 DE-627 ger DE-627 rakwb HAMILTON, P.W. verfasserin aut Classification of normal colorectal mucosa and adenocarcinoma by morphometry Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within the dataset. These were, in decreasing order of importance: (1) nuclear size, nuclear cytoplasmic ratio and nuclear position within the cell; (2) the variability of nuclear size; (3) nuclear elongation and polarity; (4) nuclear shape and its variation. Discriminant analysis was conducted between histologi-cally normal mucosa (n=10) and adenocarcinoma in ulcerative colitis (n=20). Using stepwise variable selection, the mean nuclear cytoplasmic ratio (normal, mean 20.4 (s.d. ± 2.0); tumour, mean 39.7 (s.d. ± 7.0)) and the coefficient of variation of nucleus to cell apex distance (normal, mean 19.2 (s.d ± 7.5); tumour, mean 47.8 (s.d. ± 9.1)) were chosen as discriminating features. They were used to derive a discriminant function which gave perfect discriminating between the two groups. Scatter plots of these two variables confirmed complete separation of normal mucosa from adenocarcinoma and provided a simple method of applying the discriminant function. Discriminatory performance did not deteriorate when the function was applied to further normals (n=10) and adenocarcinoma (n=10). This study highlights the descriptive differences between normal and malignant colorectal epithelium and shows that case allocation may be made to these two lesion categories using a morphometrically-derived classification rule. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| morphometry ALLEN, D.C. verfasserin aut WATT, P.C.H. verfasserin aut PATTERSON, C.C. oth BIGGART, J.D. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 11(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:11 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1365-2559.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1987 9 0 |
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10.1111/j.1365-2559.1987.tb01897.x doi (DE-627)NLEJ239532651 DE-627 ger DE-627 rakwb HAMILTON, P.W. verfasserin aut Classification of normal colorectal mucosa and adenocarcinoma by morphometry Oxford, UK Blackwell Publishing Ltd 1987 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within the dataset. These were, in decreasing order of importance: (1) nuclear size, nuclear cytoplasmic ratio and nuclear position within the cell; (2) the variability of nuclear size; (3) nuclear elongation and polarity; (4) nuclear shape and its variation. Discriminant analysis was conducted between histologi-cally normal mucosa (n=10) and adenocarcinoma in ulcerative colitis (n=20). Using stepwise variable selection, the mean nuclear cytoplasmic ratio (normal, mean 20.4 (s.d. ± 2.0); tumour, mean 39.7 (s.d. ± 7.0)) and the coefficient of variation of nucleus to cell apex distance (normal, mean 19.2 (s.d ± 7.5); tumour, mean 47.8 (s.d. ± 9.1)) were chosen as discriminating features. They were used to derive a discriminant function which gave perfect discriminating between the two groups. Scatter plots of these two variables confirmed complete separation of normal mucosa from adenocarcinoma and provided a simple method of applying the discriminant function. Discriminatory performance did not deteriorate when the function was applied to further normals (n=10) and adenocarcinoma (n=10). This study highlights the descriptive differences between normal and malignant colorectal epithelium and shows that case allocation may be made to these two lesion categories using a morphometrically-derived classification rule. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| morphometry ALLEN, D.C. verfasserin aut WATT, P.C.H. verfasserin aut PATTERSON, C.C. oth BIGGART, J.D. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 11(1987), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:11 year:1987 number:9 pages:0 http://dx.doi.org/10.1111/j.1365-2559.1987.tb01897.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1987 9 0 |
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Classification of normal colorectal mucosa and adenocarcinoma by morphometry |
| abstract |
Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within the dataset. These were, in decreasing order of importance: (1) nuclear size, nuclear cytoplasmic ratio and nuclear position within the cell; (2) the variability of nuclear size; (3) nuclear elongation and polarity; (4) nuclear shape and its variation. Discriminant analysis was conducted between histologi-cally normal mucosa (n=10) and adenocarcinoma in ulcerative colitis (n=20). Using stepwise variable selection, the mean nuclear cytoplasmic ratio (normal, mean 20.4 (s.d. ± 2.0); tumour, mean 39.7 (s.d. ± 7.0)) and the coefficient of variation of nucleus to cell apex distance (normal, mean 19.2 (s.d ± 7.5); tumour, mean 47.8 (s.d. ± 9.1)) were chosen as discriminating features. They were used to derive a discriminant function which gave perfect discriminating between the two groups. Scatter plots of these two variables confirmed complete separation of normal mucosa from adenocarcinoma and provided a simple method of applying the discriminant function. Discriminatory performance did not deteriorate when the function was applied to further normals (n=10) and adenocarcinoma (n=10). This study highlights the descriptive differences between normal and malignant colorectal epithelium and shows that case allocation may be made to these two lesion categories using a morphometrically-derived classification rule. |
| abstractGer |
Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within the dataset. These were, in decreasing order of importance: (1) nuclear size, nuclear cytoplasmic ratio and nuclear position within the cell; (2) the variability of nuclear size; (3) nuclear elongation and polarity; (4) nuclear shape and its variation. Discriminant analysis was conducted between histologi-cally normal mucosa (n=10) and adenocarcinoma in ulcerative colitis (n=20). Using stepwise variable selection, the mean nuclear cytoplasmic ratio (normal, mean 20.4 (s.d. ± 2.0); tumour, mean 39.7 (s.d. ± 7.0)) and the coefficient of variation of nucleus to cell apex distance (normal, mean 19.2 (s.d ± 7.5); tumour, mean 47.8 (s.d. ± 9.1)) were chosen as discriminating features. They were used to derive a discriminant function which gave perfect discriminating between the two groups. Scatter plots of these two variables confirmed complete separation of normal mucosa from adenocarcinoma and provided a simple method of applying the discriminant function. Discriminatory performance did not deteriorate when the function was applied to further normals (n=10) and adenocarcinoma (n=10). This study highlights the descriptive differences between normal and malignant colorectal epithelium and shows that case allocation may be made to these two lesion categories using a morphometrically-derived classification rule. |
| abstract_unstemmed |
Semi-automatic image analysis was used to make a morphometrical assessment of 15 nuclear and cellular variables in normal (n=20) and malignant (n=30) colorectal epithelium. Principal components analysis on the matrix of correlations between variables identified four main sources of variation within the dataset. These were, in decreasing order of importance: (1) nuclear size, nuclear cytoplasmic ratio and nuclear position within the cell; (2) the variability of nuclear size; (3) nuclear elongation and polarity; (4) nuclear shape and its variation. Discriminant analysis was conducted between histologi-cally normal mucosa (n=10) and adenocarcinoma in ulcerative colitis (n=20). Using stepwise variable selection, the mean nuclear cytoplasmic ratio (normal, mean 20.4 (s.d. ± 2.0); tumour, mean 39.7 (s.d. ± 7.0)) and the coefficient of variation of nucleus to cell apex distance (normal, mean 19.2 (s.d ± 7.5); tumour, mean 47.8 (s.d. ± 9.1)) were chosen as discriminating features. They were used to derive a discriminant function which gave perfect discriminating between the two groups. Scatter plots of these two variables confirmed complete separation of normal mucosa from adenocarcinoma and provided a simple method of applying the discriminant function. Discriminatory performance did not deteriorate when the function was applied to further normals (n=10) and adenocarcinoma (n=10). This study highlights the descriptive differences between normal and malignant colorectal epithelium and shows that case allocation may be made to these two lesion categories using a morphometrically-derived classification rule. |
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| title_short |
Classification of normal colorectal mucosa and adenocarcinoma by morphometry |
| url |
http://dx.doi.org/10.1111/j.1365-2559.1987.tb01897.x |
| remote_bool |
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| author2 |
ALLEN, D.C. WATT, P.C.H. PATTERSON, C.C. BIGGART, J.D. |
| author2Str |
ALLEN, D.C. WATT, P.C.H. PATTERSON, C.C. BIGGART, J.D. |
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NLEJ243927045 |
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| doi_str |
10.1111/j.1365-2559.1987.tb01897.x |
| up_date |
2024-07-06T07:42:55.920Z |
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| score |
7.399476 |