A piperacillin-tazobactam resistant Escherichia coli strain isolated from a faecal sample of a healthy volunteer
Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662,...
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| Autor*in: |
London, N. [verfasserIn] Thomson, C.J. [verfasserIn] Amyes, S.G.B. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1995 |
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Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: FEMS immunology and medical microbiology - Federation of European Microbiological Societies ; GKD-ID: 114439X, Oxford [u.a.] : Wiley-Blackwell, 1993, 11(1995), 2, Seite 0 |
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volume:11 ; year:1995 ; number:2 ; pages:0 |
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| DOI / URN: |
10.1111/j.1574-695X.1995.tb00096.x |
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| 520 | |a Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662, was also resistant to piperacillin-tazobactam but susceptible to amoxycillin-clavulanic acid. The piperacillin-tazobactam resistance determinant was transferable to standard E. coli strains by conjugation. However, the strain produced a β-lactamase with several characteristics very similar to those of the TEM-1 β-lactamase, i.e. pI of 5.4, an Mr value of 22 000 and a comparable substrate profile. The enzyme was as efficiently inhibited by clavulanic acid and tazobactam as the TEM-1 and TEM-2 β-lactamases but more than the amoxycillin-clavulanic acid-resistant TRC-1 enzyme. The transferable resistance to piperacillin-tazobactam appears to be mediated by a novel resistance mechanism that has previously not been described. | ||
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10.1111/j.1574-695X.1995.tb00096.x doi (DE-627)NLEJ239816994 DE-627 ger DE-627 rakwb London, N. verfasserin aut A piperacillin-tazobactam resistant Escherichia coli strain isolated from a faecal sample of a healthy volunteer Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662, was also resistant to piperacillin-tazobactam but susceptible to amoxycillin-clavulanic acid. The piperacillin-tazobactam resistance determinant was transferable to standard E. coli strains by conjugation. However, the strain produced a β-lactamase with several characteristics very similar to those of the TEM-1 β-lactamase, i.e. pI of 5.4, an Mr value of 22 000 and a comparable substrate profile. The enzyme was as efficiently inhibited by clavulanic acid and tazobactam as the TEM-1 and TEM-2 β-lactamases but more than the amoxycillin-clavulanic acid-resistant TRC-1 enzyme. The transferable resistance to piperacillin-tazobactam appears to be mediated by a novel resistance mechanism that has previously not been described. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| TEM β-lactamase Thomson, C.J. verfasserin aut Amyes, S.G.B. verfasserin aut Stobberingh, E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 11(1995), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:11 year:1995 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.1995.tb00096.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1995 2 0 |
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10.1111/j.1574-695X.1995.tb00096.x doi (DE-627)NLEJ239816994 DE-627 ger DE-627 rakwb London, N. verfasserin aut A piperacillin-tazobactam resistant Escherichia coli strain isolated from a faecal sample of a healthy volunteer Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662, was also resistant to piperacillin-tazobactam but susceptible to amoxycillin-clavulanic acid. The piperacillin-tazobactam resistance determinant was transferable to standard E. coli strains by conjugation. However, the strain produced a β-lactamase with several characteristics very similar to those of the TEM-1 β-lactamase, i.e. pI of 5.4, an Mr value of 22 000 and a comparable substrate profile. The enzyme was as efficiently inhibited by clavulanic acid and tazobactam as the TEM-1 and TEM-2 β-lactamases but more than the amoxycillin-clavulanic acid-resistant TRC-1 enzyme. The transferable resistance to piperacillin-tazobactam appears to be mediated by a novel resistance mechanism that has previously not been described. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| TEM β-lactamase Thomson, C.J. verfasserin aut Amyes, S.G.B. verfasserin aut Stobberingh, E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 11(1995), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:11 year:1995 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.1995.tb00096.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1995 2 0 |
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10.1111/j.1574-695X.1995.tb00096.x doi (DE-627)NLEJ239816994 DE-627 ger DE-627 rakwb London, N. verfasserin aut A piperacillin-tazobactam resistant Escherichia coli strain isolated from a faecal sample of a healthy volunteer Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662, was also resistant to piperacillin-tazobactam but susceptible to amoxycillin-clavulanic acid. The piperacillin-tazobactam resistance determinant was transferable to standard E. coli strains by conjugation. However, the strain produced a β-lactamase with several characteristics very similar to those of the TEM-1 β-lactamase, i.e. pI of 5.4, an Mr value of 22 000 and a comparable substrate profile. The enzyme was as efficiently inhibited by clavulanic acid and tazobactam as the TEM-1 and TEM-2 β-lactamases but more than the amoxycillin-clavulanic acid-resistant TRC-1 enzyme. The transferable resistance to piperacillin-tazobactam appears to be mediated by a novel resistance mechanism that has previously not been described. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| TEM β-lactamase Thomson, C.J. verfasserin aut Amyes, S.G.B. verfasserin aut Stobberingh, E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 11(1995), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:11 year:1995 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.1995.tb00096.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1995 2 0 |
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10.1111/j.1574-695X.1995.tb00096.x doi (DE-627)NLEJ239816994 DE-627 ger DE-627 rakwb London, N. verfasserin aut A piperacillin-tazobactam resistant Escherichia coli strain isolated from a faecal sample of a healthy volunteer Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662, was also resistant to piperacillin-tazobactam but susceptible to amoxycillin-clavulanic acid. The piperacillin-tazobactam resistance determinant was transferable to standard E. coli strains by conjugation. However, the strain produced a β-lactamase with several characteristics very similar to those of the TEM-1 β-lactamase, i.e. pI of 5.4, an Mr value of 22 000 and a comparable substrate profile. The enzyme was as efficiently inhibited by clavulanic acid and tazobactam as the TEM-1 and TEM-2 β-lactamases but more than the amoxycillin-clavulanic acid-resistant TRC-1 enzyme. The transferable resistance to piperacillin-tazobactam appears to be mediated by a novel resistance mechanism that has previously not been described. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| TEM β-lactamase Thomson, C.J. verfasserin aut Amyes, S.G.B. verfasserin aut Stobberingh, E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 11(1995), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:11 year:1995 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.1995.tb00096.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1995 2 0 |
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10.1111/j.1574-695X.1995.tb00096.x doi (DE-627)NLEJ239816994 DE-627 ger DE-627 rakwb London, N. verfasserin aut A piperacillin-tazobactam resistant Escherichia coli strain isolated from a faecal sample of a healthy volunteer Oxford, UK Blackwell Publishing Ltd 1995 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662, was also resistant to piperacillin-tazobactam but susceptible to amoxycillin-clavulanic acid. The piperacillin-tazobactam resistance determinant was transferable to standard E. coli strains by conjugation. However, the strain produced a β-lactamase with several characteristics very similar to those of the TEM-1 β-lactamase, i.e. pI of 5.4, an Mr value of 22 000 and a comparable substrate profile. The enzyme was as efficiently inhibited by clavulanic acid and tazobactam as the TEM-1 and TEM-2 β-lactamases but more than the amoxycillin-clavulanic acid-resistant TRC-1 enzyme. The transferable resistance to piperacillin-tazobactam appears to be mediated by a novel resistance mechanism that has previously not been described. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| TEM β-lactamase Thomson, C.J. verfasserin aut Amyes, S.G.B. verfasserin aut Stobberingh, E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 11(1995), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:11 year:1995 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.1995.tb00096.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1995 2 0 |
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Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662, was also resistant to piperacillin-tazobactam but susceptible to amoxycillin-clavulanic acid. The piperacillin-tazobactam resistance determinant was transferable to standard E. coli strains by conjugation. However, the strain produced a β-lactamase with several characteristics very similar to those of the TEM-1 β-lactamase, i.e. pI of 5.4, an Mr value of 22 000 and a comparable substrate profile. The enzyme was as efficiently inhibited by clavulanic acid and tazobactam as the TEM-1 and TEM-2 β-lactamases but more than the amoxycillin-clavulanic acid-resistant TRC-1 enzyme. The transferable resistance to piperacillin-tazobactam appears to be mediated by a novel resistance mechanism that has previously not been described. |
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Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662, was also resistant to piperacillin-tazobactam but susceptible to amoxycillin-clavulanic acid. The piperacillin-tazobactam resistance determinant was transferable to standard E. coli strains by conjugation. However, the strain produced a β-lactamase with several characteristics very similar to those of the TEM-1 β-lactamase, i.e. pI of 5.4, an Mr value of 22 000 and a comparable substrate profile. The enzyme was as efficiently inhibited by clavulanic acid and tazobactam as the TEM-1 and TEM-2 β-lactamases but more than the amoxycillin-clavulanic acid-resistant TRC-1 enzyme. The transferable resistance to piperacillin-tazobactam appears to be mediated by a novel resistance mechanism that has previously not been described. |
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Abstract As part of a surveillance programme of the prevalence of antibiotic resistance, the faecal bacteria of healthy people (n= 1348) were examined, and the antibiotic resistance of the Escherichia coli strains determined. One strain out of 142 amoxycillin-resistant isolates, E. coli strain 1662, was also resistant to piperacillin-tazobactam but susceptible to amoxycillin-clavulanic acid. The piperacillin-tazobactam resistance determinant was transferable to standard E. coli strains by conjugation. However, the strain produced a β-lactamase with several characteristics very similar to those of the TEM-1 β-lactamase, i.e. pI of 5.4, an Mr value of 22 000 and a comparable substrate profile. The enzyme was as efficiently inhibited by clavulanic acid and tazobactam as the TEM-1 and TEM-2 β-lactamases but more than the amoxycillin-clavulanic acid-resistant TRC-1 enzyme. The transferable resistance to piperacillin-tazobactam appears to be mediated by a novel resistance mechanism that has previously not been described. |
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A piperacillin-tazobactam resistant Escherichia coli strain isolated from a faecal sample of a healthy volunteer |
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Thomson, C.J. Amyes, S.G.B. Stobberingh, E. |
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