Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea
Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concen...
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| Autor*in: |
Luboshitzky, Rafael [verfasserIn] Lavi, Shahar [verfasserIn] Thuma, Isaama [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1996 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of pineal research - Oxford [u.a.] : Wiley-Blackwell, 1984, 20(1996), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:20 ; year:1996 ; number:2 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1600-079X.1996.tb00242.x |
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NLEJ240013212 |
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| 245 | 1 | 0 | |a Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea |
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| 520 | |a Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. Pulsatile melatonin secretion is unaltered in these patients, and the frequent occurrence of amenorrhea in this population is not mediated by melatonin. | ||
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10.1111/j.1600-079X.1996.tb00242.x doi (DE-627)NLEJ240013212 DE-627 ger DE-627 rakwb Luboshitzky, Rafael verfasserin aut Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea Oxford, UK Blackwell Publishing Ltd 1996 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. Pulsatile melatonin secretion is unaltered in these patients, and the frequent occurrence of amenorrhea in this population is not mediated by melatonin. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| pulsatile melatonin secretion Lavi, Shahar verfasserin aut Thuma, Isaama verfasserin aut Lavie, Peretz oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 20(1996), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:20 year:1996 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1996.tb00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1996 2 0 |
| spelling |
10.1111/j.1600-079X.1996.tb00242.x doi (DE-627)NLEJ240013212 DE-627 ger DE-627 rakwb Luboshitzky, Rafael verfasserin aut Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea Oxford, UK Blackwell Publishing Ltd 1996 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. Pulsatile melatonin secretion is unaltered in these patients, and the frequent occurrence of amenorrhea in this population is not mediated by melatonin. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| pulsatile melatonin secretion Lavi, Shahar verfasserin aut Thuma, Isaama verfasserin aut Lavie, Peretz oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 20(1996), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:20 year:1996 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1996.tb00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1996 2 0 |
| allfields_unstemmed |
10.1111/j.1600-079X.1996.tb00242.x doi (DE-627)NLEJ240013212 DE-627 ger DE-627 rakwb Luboshitzky, Rafael verfasserin aut Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea Oxford, UK Blackwell Publishing Ltd 1996 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. Pulsatile melatonin secretion is unaltered in these patients, and the frequent occurrence of amenorrhea in this population is not mediated by melatonin. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| pulsatile melatonin secretion Lavi, Shahar verfasserin aut Thuma, Isaama verfasserin aut Lavie, Peretz oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 20(1996), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:20 year:1996 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1996.tb00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1996 2 0 |
| allfieldsGer |
10.1111/j.1600-079X.1996.tb00242.x doi (DE-627)NLEJ240013212 DE-627 ger DE-627 rakwb Luboshitzky, Rafael verfasserin aut Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea Oxford, UK Blackwell Publishing Ltd 1996 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. Pulsatile melatonin secretion is unaltered in these patients, and the frequent occurrence of amenorrhea in this population is not mediated by melatonin. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| pulsatile melatonin secretion Lavi, Shahar verfasserin aut Thuma, Isaama verfasserin aut Lavie, Peretz oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 20(1996), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:20 year:1996 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1996.tb00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1996 2 0 |
| allfieldsSound |
10.1111/j.1600-079X.1996.tb00242.x doi (DE-627)NLEJ240013212 DE-627 ger DE-627 rakwb Luboshitzky, Rafael verfasserin aut Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea Oxford, UK Blackwell Publishing Ltd 1996 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. Pulsatile melatonin secretion is unaltered in these patients, and the frequent occurrence of amenorrhea in this population is not mediated by melatonin. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| pulsatile melatonin secretion Lavi, Shahar verfasserin aut Thuma, Isaama verfasserin aut Lavie, Peretz oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 20(1996), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:20 year:1996 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1996.tb00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 1996 2 0 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ240013212</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707101534.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120426s1996 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1600-079X.1996.tb00242.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ240013212</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Luboshitzky, Rafael</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1996</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. 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Luboshitzky, Rafael |
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Luboshitzky, Rafael misc pulsatile melatonin secretion Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea |
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Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea pulsatile melatonin secretion |
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nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea |
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Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea |
| abstract |
Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. Pulsatile melatonin secretion is unaltered in these patients, and the frequent occurrence of amenorrhea in this population is not mediated by melatonin. |
| abstractGer |
Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. Pulsatile melatonin secretion is unaltered in these patients, and the frequent occurrence of amenorrhea in this population is not mediated by melatonin. |
| abstract_unstemmed |
Abstract: To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every 15 min from 1900 hr to 0700 hr in a controlled light-dark environment with simultaneous sleep recordings. The mean (±SD) light-time period, dark-time period, and the integrated nocturnal melatonin secretion values (area under the curve, or AUC) in patients (51 ± 11 pmol/L, 157 ± 33 pmol/L, and 102 ± 19 pmol/min-L × 103, respectively) were similar to the values obtained in controls (79 ± 39, 165 ± 44, 111 ± 31, respectively). The onset of the nocturnal melatonin rise, peak level, and peak time were similar in the two groups. A significant nocturnal prolactin rise was observed in patients (112 ± 9 vs. 65 ± 11 μg/L, P < 0.006) and controls (19 ± 2 vs. 10 ± 3 μg/L, P < 0.006). The time of prolactin peak was similar in patients and controls (0424 ± 3: 36 vs. 0350 ± 2: 21) and paralleled that of melatonin (0354 ± 1: 46 vs. 0337 ± 1: 30). The mean ± SD light-time period, dark-time period, and the AUC values of LH were similar in patients and controls. The number of LH pulses in patients (7.2 ±1.9 per 12 hr) were not different from those in controls (7.7 ±2.1). The LH pulse interval was 100 ± 22 min in patients compared with 94 ± 23 min in controls. The mean (±SD) nocturnal estradiol (E2) levels were significantly lower in patients (84 ±15 pmol/L) than in controls (224 ± 77) (P < 0.005). Analysis of LH and melatonin secretory profiles revealed significant pulses for both hormones. No significant relationship was observed between the LH and melatonin pulses. However, a negative correlation between LH pulse amplitude and the number of melatonin pulses (P < 0.04) and a positive correlation between LH amplitude and duration of melatonin pulses (P < 0.04) were observed. Taken together, these data suggest that the suppression of normal ovarian cycles in women with hyperprolactinemic amenorrhea owing to pituitary microadenoma may be mediated by blocking of gonadotropin action by prolactin at the ovarian level; yet it remains possible that chronically elevated prolactin might prevent the LH surge and thus lead to amenorrhea. Pulsatile melatonin secretion is unaltered in these patients, and the frequent occurrence of amenorrhea in this population is not mediated by melatonin. |
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