Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas
This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to mod...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhang, L. [verfasserIn] Xiao, Y. [verfasserIn] Priddy, R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1994 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of oral pathology & medicine - Oxford [u.a.] : Wiley-Blackwell, 1972, 23(1994), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:23 ; year:1994 ; number:2 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1600-0714.1994.tb00260.x |
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NLEJ240127552 |
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| 520 | |a This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions. | ||
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10.1111/j.1600-0714.1994.tb00260.x doi (DE-627)NLEJ240127552 DE-627 ger DE-627 rakwb Zhang, L. verfasserin aut Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| GST-φ Xiao, Y. verfasserin aut Priddy, R. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 23(1994), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:23 year:1994 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1994.tb00260.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 23 1994 2 0 |
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10.1111/j.1600-0714.1994.tb00260.x doi (DE-627)NLEJ240127552 DE-627 ger DE-627 rakwb Zhang, L. verfasserin aut Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| GST-φ Xiao, Y. verfasserin aut Priddy, R. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 23(1994), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:23 year:1994 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1994.tb00260.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 23 1994 2 0 |
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10.1111/j.1600-0714.1994.tb00260.x doi (DE-627)NLEJ240127552 DE-627 ger DE-627 rakwb Zhang, L. verfasserin aut Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| GST-φ Xiao, Y. verfasserin aut Priddy, R. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 23(1994), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:23 year:1994 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1994.tb00260.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 23 1994 2 0 |
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10.1111/j.1600-0714.1994.tb00260.x doi (DE-627)NLEJ240127552 DE-627 ger DE-627 rakwb Zhang, L. verfasserin aut Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| GST-φ Xiao, Y. verfasserin aut Priddy, R. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 23(1994), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:23 year:1994 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1994.tb00260.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 23 1994 2 0 |
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10.1111/j.1600-0714.1994.tb00260.x doi (DE-627)NLEJ240127552 DE-627 ger DE-627 rakwb Zhang, L. verfasserin aut Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| GST-φ Xiao, Y. verfasserin aut Priddy, R. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 23(1994), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:23 year:1994 number:2 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1994.tb00260.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 23 1994 2 0 |
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Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas |
| abstract |
This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions. |
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This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions. |
| abstract_unstemmed |
This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ240127552</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506010316.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120426s1994 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1600-0714.1994.tb00260.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ240127552</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Zhang, L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1994</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-φ) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-φ staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia. carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-φ staining was evident mainly in the cytoplasm. Severe dysplasia. CIS and SCC were also characterized by areas of cells with intensive nuclear GST-φ staining. These findings support the hypothesis that GST-φ plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2006</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2006||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">GST-φ</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xiao, Y.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Priddy, R.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of oral pathology & medicine</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1972</subfield><subfield code="g">23(1994), 2, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243927231</subfield><subfield code="w">(DE-600)2026385-5</subfield><subfield code="x">1600-0714</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:1994</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1600-0714.1994.tb00260.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">1994</subfield><subfield code="e">2</subfield><subfield code="h">0</subfield></datafield></record></collection>
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