Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin
Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stim...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Modéer, T. [verfasserIn] Anduren, I. [verfasserIn] Lerner, U. H. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1992 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of oral pathology & medicine - Oxford [u.a.] : Wiley-Blackwell, 1972, 21(1992), 6, Seite 0 |
| Übergeordnetes Werk: |
volume:21 ; year:1992 ; number:6 ; pages:0 |
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| DOI / URN: |
10.1111/j.1600-0714.1992.tb01005.x |
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| 520 | |a Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. The results indicate that PHT medication results in an upregulation of prostanoid formation in gingival fibroblasts partly due to an increased phospholipase A; activity and partly due to an increased cyclooxygenase activity. | ||
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10.1111/j.1600-0714.1992.tb01005.x doi (DE-627)NLEJ240129148 DE-627 ger DE-627 rakwb Modéer, T. verfasserin aut Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. The results indicate that PHT medication results in an upregulation of prostanoid formation in gingival fibroblasts partly due to an increased phospholipase A; activity and partly due to an increased cyclooxygenase activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| gingival fibroblasts Anduren, I. verfasserin aut Lerner, U. H. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 21(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:21 year:1992 number:6 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1992.tb01005.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1992 6 0 |
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10.1111/j.1600-0714.1992.tb01005.x doi (DE-627)NLEJ240129148 DE-627 ger DE-627 rakwb Modéer, T. verfasserin aut Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. The results indicate that PHT medication results in an upregulation of prostanoid formation in gingival fibroblasts partly due to an increased phospholipase A; activity and partly due to an increased cyclooxygenase activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| gingival fibroblasts Anduren, I. verfasserin aut Lerner, U. H. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 21(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:21 year:1992 number:6 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1992.tb01005.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1992 6 0 |
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10.1111/j.1600-0714.1992.tb01005.x doi (DE-627)NLEJ240129148 DE-627 ger DE-627 rakwb Modéer, T. verfasserin aut Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. The results indicate that PHT medication results in an upregulation of prostanoid formation in gingival fibroblasts partly due to an increased phospholipase A; activity and partly due to an increased cyclooxygenase activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| gingival fibroblasts Anduren, I. verfasserin aut Lerner, U. H. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 21(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:21 year:1992 number:6 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1992.tb01005.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1992 6 0 |
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10.1111/j.1600-0714.1992.tb01005.x doi (DE-627)NLEJ240129148 DE-627 ger DE-627 rakwb Modéer, T. verfasserin aut Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. The results indicate that PHT medication results in an upregulation of prostanoid formation in gingival fibroblasts partly due to an increased phospholipase A; activity and partly due to an increased cyclooxygenase activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| gingival fibroblasts Anduren, I. verfasserin aut Lerner, U. H. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 21(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:21 year:1992 number:6 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1992.tb01005.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1992 6 0 |
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10.1111/j.1600-0714.1992.tb01005.x doi (DE-627)NLEJ240129148 DE-627 ger DE-627 rakwb Modéer, T. verfasserin aut Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. The results indicate that PHT medication results in an upregulation of prostanoid formation in gingival fibroblasts partly due to an increased phospholipase A; activity and partly due to an increased cyclooxygenase activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| gingival fibroblasts Anduren, I. verfasserin aut Lerner, U. H. verfasserin aut In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 21(1992), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:21 year:1992 number:6 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1992.tb01005.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1992 6 0 |
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Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin |
| abstract |
Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. The results indicate that PHT medication results in an upregulation of prostanoid formation in gingival fibroblasts partly due to an increased phospholipase A; activity and partly due to an increased cyclooxygenase activity. |
| abstractGer |
Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. The results indicate that PHT medication results in an upregulation of prostanoid formation in gingival fibroblasts partly due to an increased phospholipase A; activity and partly due to an increased cyclooxygenase activity. |
| abstract_unstemmed |
Prostaglandin E2 (PGE2) formation was studied in human gingival fibroblasts derived from three epileptic patients before and after 9 months of phenytoin (PHT) therapy. Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. The results indicate that PHT medication results in an upregulation of prostanoid formation in gingival fibroblasts partly due to an increased phospholipase A; activity and partly due to an increased cyclooxygenase activity. |
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| title_short |
Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin |
| url |
http://dx.doi.org/10.1111/j.1600-0714.1992.tb01005.x |
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| author2 |
Anduren, I. Lerner, U. H. |
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| doi_str |
10.1111/j.1600-0714.1992.tb01005.x |
| up_date |
2024-07-06T09:09:04.102Z |
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Interleukin I (IL-1α; 0.3-6.0 ng/ml), (IL-1β; 10–1000 pg/ml) and tumour necrosis factor (TNFα; 0.01–O.I μg/ml) dose-dependently stimulated the formation of PGE: in 24 h cultures. In fibroblasts, derived after 9 months of PHT therapy. IL-1α, IL-1β and TNFα induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. IL-1β induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy. Addition of exogenous AA caused a spontaneous increase of PGE: formation in PHT fibroblasts compared to that in fibroblasts isolated before the PHT treatment. 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7.401124 |